Search Results - "Browne, Gareth J."

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma by Caramel, Julie, Papadogeorgakis, Eftychios, Hill, Louise, Browne, Gareth J., Richard, Geoffrey, Wierinckx, Anne, Saldanha, Gerald, Osborne, Joy, Hutchinson, Peter, Tse, Gina, Lachuer, Joël, Puisieux, Alain, Pringle, J. Howard, Ansieau, Stéphane, Tulchinsky, Eugene

“…Aberrant expression of embryonic epithelial-mesenchymal transition-inducing transcription factors (EMT-TFs) in epithelial cells triggers EMT, neoplastic…”
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EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice by Morel, Anne-Pierre, Hinkal, George W, Thomas, Clémence, Fauvet, Frédérique, Courtois-Cox, Stéphanie, Wierinckx, Anne, Devouassoux-Shisheboran, Mojgan, Treilleux, Isabelle, Tissier, Agnès, Gras, Baptiste, Pourchet, Julie, Puisieux, Isabelle, Browne, Gareth J, Spicer, Douglas B, Lachuer, Joël, Ansieau, Stéphane, Puisieux, Alain

“…The epithelial-mesenchymal transition (EMT) is an embryonic transdifferentiation process consisting of conversion of polarized epithelial cells to motile…”
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The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses by Smith, Ewan M., Finn, Stephen G., Tee, Andrew R., Browne, Gareth J., Proud, Christopher G.

“…Amino acids positively regulate signaling through the mammalian target of rapamycin (mTOR). Recent work demonstrated the importance of the tuberous sclerosis…”
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Characterization of a novel potency endpoint for the evaluation of immune checkpoint blockade in humanized mice by Matas-Céspedes, Alba, Lapointe, Jean-Martin, Elder, Matthew J, Browne, Gareth J, Dovedi, Simon J, de Haan, Lolke, Maguire, Shaun, Stebbings, Richard

“…Humanized mice are emerging as valuable models to experimentally evaluate the impact of different immunotherapeutics on the human immune system. These…”
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Stimulation of the AMP-activated Protein Kinase Leads to Activation of Eukaryotic Elongation Factor 2 Kinase and to Its Phosphorylation at a Novel Site, Serine 398 by Browne, Gareth J., Finn, Stephen G., Proud, Christopher G.

“…Protein synthesis consumes a high proportion of the metabolic energy of mammalian cells, and most of this is used by peptide chain elongation. An important…”
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SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer by Sayan, A. Emre, Griffiths, Thomas R, Pal, Raj, Browne, Gareth J, Ruddick, Andrew, Yagci, Tamer, Edwards, Richard, Mayer, Nick J, Qazi, Hasan, Goyal, Sandeep, Fernandez, Serena, Straatman, Kees, Jones, George D.D, Bowman, Karen J, Colquhoun, Alexandra, Mellon, J. Kilian, Kriajevska, Marina, Tulchinsky, Eugene

“…The epithelial-mesenchymal transition (EMT) contributes to cancer metastasis. Two ZEB family members, ZEB1 and ZEB2(SIP1), inhibit transcription of the…”
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Mechanistic insights into the rational design of masked antibodies by Orozco, Carolina T., Bersellini, Manuela, Irving, Lorraine M., Howard, Wesley W., Hargreaves, David, Devine, Paul W. A., Siouve, Elise, Browne, Gareth J., Bond, Nicholas J., Phillips, Jonathan J., Ravn, Peter, Jackson, Sophie E.

“…Although monoclonal antibodies have greatly improved cancer therapy, they can trigger side effects due to on-target, off-tumor toxicity. Over the past decade,…”
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A Novel mTOR-Regulated Phosphorylation Site in Elongation Factor 2 Kinase Modulates the Activity of the Kinase and Its Binding to Calmodulin by Browne, Gareth J., Proud, Christopher G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2 by Sayan, Berna S, Yang, Ai Li, Conforti, Franco, Tucci, Paola, Piro, Maria Cristina, Browne, Gareth J, Agostini, Massimiliano, Bernardini, Sergio, Knight, Richard A, Mak, Tak W, Melino, Gerry

“…p73 is a p53-related transcription factor with fundamental roles in development and tumor suppression. Transcription from two different promoters on the p73…”
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Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia by Harding, Stephen J., Browne, Gareth J., Miller, Bryan W., Prigent, Sally A., Dickens, Martin

“…p38 MAPK is activated potently during cardiac ischaemia, although the precise mechanism by which it is activated is unclear. We used the isolated perfused rat…”
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Reversible translocation of ASK1 to a Triton-X100 insoluble cytoplasmic compartment during cardiac myocyte cell stress by Browne, Gareth J., Dickens, Martin

“…ASK1 is a cellular stress-responsive MAPKKK which activates the JNK and p38 MAPK pathways that play a key role in the response of cardiac myocytes to redox…”
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Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1 + Activated T Cells by Dovedi, Simon J, Elder, Matthew J, Yang, Chunning, Sitnikova, Suzanne I, Irving, Lorraine, Hansen, Anna, Hair, James, Jones, Des C, Hasani, Sumati, Wang, Bo, Im, Seock-Ah, Tran, Ben, Subramaniam, Deepa S, Gainer, Shelby D, Vashisht, Kapil, Lewis, Arthur, Jin, Xiaofang, Kentner, Stacy, Mulgrew, Kathy, Wang, Yaya, Overstreet, Michael G, Dodgson, James, Wu, Yanli, Palazon, Asis, Morrow, Michelle, Rainey, Godfrey J, Browne, Gareth J, Neal, Frances, Murray, Thomas V, Toloczko, Aleksandra D, Dall'Acqua, William, Achour, Ikbel, Freeman, Daniel J, Wilkinson, Robert W, Mazor, Yariv

“…The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events…”
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SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein by Browne, Gareth J, Fardilha, Margarida, Oxenham, Senga K, Wu, Wenjuan, Helps, Nicholas R, da Cruz E Silva, Odete A B, Cohen, Patricia T W, da Cruz E Silva, Edgar F

“…PP1 (protein phosphatase 1) is a ubiquitously expressed serine/threonine-specific protein phosphatase whose activity towards different substrates appears to be…”
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PPP1R6, a novel member of the family of glycogen-targetting subunits of protein phosphatase 1 by Armstrong, Christopher G, Browne, Gareth J, Cohen, Philip, Cohen, Patricia T.W

“…A complementary DNA encoding a novel human protein phosphatase 1 (PP1) glycogen-targetting subunit of molecular mass 33 kDa has been sequenced. PPP1R6 is 31%…”
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Activation of AMP-Activated Protein Kinase Leads to the Phosphorylation of Elongation Factor 2 and an Inhibition of Protein Synthesis by Horman, Sandrine, Browne, Gareth J., Krause, Ulrike, Patel, Jigna V., Vertommen, Didier, Bertrand, Luc, Lavoinne, Alain, Hue, Louis, Proud, Christopher G., Rider, Mark H.

“…Protein synthesis, in particular peptide-chain elongation, consumes cellular energy. Anoxia activates AMP-activated protein kinase (AMPK, see [1]), resulting…”
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Regulation of peptide‐chain elongation in mammalian cells by Browne, Gareth J., Proud, Christopher G.

“…The elongation phase of mRNA translation is the stage at which the polypeptide is assembled and requires a substantial amount of metabolic energy. Translation…”
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Transcriptional and Post-Translational Targeting of Myocyte Stress Protein 1 (MS1) by the JNK Pathway in Cardiac Myocytes by Hay, Joanna M, Jordan, Eva S, Browne, Gareth J, Bottrill, Andrew R, Prigent, Sally A, Dickens, Martin

“…Myocyte Stress Protein 1 (MS1) is a muscle-specific, stress-responsive, regulator of gene expression. It was originally identified in embryonic mouse heart…”
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High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2 by Elo, Mika A., Karjalainen, Hannu M., Sironen, Reijo K., Valmu, Leena, Redpath, Nicholas T., Browne, Gareth J., Kalkkinen, Nisse, Helminen, Heikki J., Lammi, Mikko J.

“…High continuous hydrostatic pressure is known to inhibit the total cellular protein synthesis. In this study, our goal was to identify pressure‐regulated…”
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Assay of protein phosphatase 1 complexes by Cohen, Patricia T, Browne, Gareth J, Delibegovic, Mirela, Munro, Shonagh

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Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex by Ajuh, P M, Browne, G J, Hawkes, N A, Cohen, P T, Roberts, S G, Lamond, A I

“…We have screened a human cDNA expression library with a digoxygenin-labelled protein phosphatase 1 (PP1) probe to identify novel PP1 interacting proteins…”
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