Search Results - "Browne, Christopher M."

The Yeast Eukaryotic Translation Initiation Factor 2B Translation Initiation Complex Interacts with the Fatty Acid Synthesis Enzyme YBR159W and Endoplasmic Reticulum Membranes by Browne, Christopher M., Samir, Parimal, Fites, J. Scott, Villarreal, Seth A., Link, Andrew J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of Changing Ribosome Protein Compositions using Mass Spectrometry by Samir, Parimal, Browne, Christopher M., Rahul, Sun, Ming, Shen, Bingxin, Li, Wen, Frank, Joachim, Link, Andrew J.

“…The regulatory role of the ribosome in gene expression has come into sharper focus. It has been proposed that ribosomes are dynamic complexes capable of…”
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A Time‐Resolved Cryo‐EM Study of Saccharomyces cerevisiae 80S Ribosome Protein Composition in Response to a Change in Carbon Source by Sun, Ming, Shen, Bingxin, Li, Wen, Samir, Parimal, Browne, Christopher M., Link, Andrew J., Frank, Joachim

“…The role of the ribosome in the regulation of gene expression has come into increased focus. It is proposed that ribosomes are catalytic engines capable of…”
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Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo by Dubiella, Christian, Pinch, Benika J., Koikawa, Kazuhiro, Zaidman, Daniel, Poon, Evon, Manz, Theresa D., Nabet, Behnam, He, Shuning, Resnick, Efrat, Rogel, Adi, Langer, Ellen M., Daniel, Colin J., Seo, Hyuk-Soo, Chen, Ying, Adelmant, Guillaume, Sharifzadeh, Shabnam, Ficarro, Scott B., Jamin, Yann, Martins da Costa, Barbara, Zimmerman, Mark W., Lian, Xiaolan, Kibe, Shin, Kozono, Shingo, Doctor, Zainab M., Browne, Christopher M., Yang, Annan, Stoler-Barak, Liat, Shah, Richa B., Vangos, Nicholas E., Geffken, Ezekiel A., Oren, Roni, Koide, Eriko, Sidi, Samuel, Shulman, Ziv, Wang, Chu, Marto, Jarrod A., Dhe-Paganon, Sirano, Look, Thomas, Zhou, Xiao Zhen, Lu, Kun Ping, Sears, Rosalie C., Chesler, Louis, Gray, Nathanael S., London, Nir

“…The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors. However, despite considerable efforts, Pin1…”
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Identification of a potent and selective covalent Pin1 inhibitor by Pinch, Benika J., Doctor, Zainab M., Nabet, Behnam, Browne, Christopher M., Seo, Hyuk-Soo, Mohardt, Mikaela L., Kozono, Shingo, Lian, Xiaolan, Manz, Theresa D., Chun, Yujin, Kibe, Shin, Zaidman, Daniel, Daitchman, Dina, Yeoh, Zoe C., Vangos, Nicholas E., Geffken, Ezekiel A., Tan, Li, Ficarro, Scott B., London, Nir, Marto, Jarrod A., Buratowski, Stephen, Dhe-Paganon, Sirano, Zhou, Xiao Zhen, Lu, Kun Ping, Gray, Nathanael S.

“…Peptidyl-prolyl cis / trans isomerase NIMA-interacting 1 (Pin1) is commonly overexpressed in human cancers, including pancreatic ductal adenocarcinoma (PDAC)…”
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A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification by Browne, Christopher M, Jiang, Baishan, Ficarro, Scott B, Doctor, Zainab M, Johnson, Jared L, Card, Joseph D, Sivakumaren, Sindhu Carmen, Alexander, William M, Yaron, Tomer M, Murphy, Charles J, Kwiatkowski, Nicholas P, Zhang, Tinghu, Cantley, Lewis C, Gray, Nathanael S, Marto, Jarrod A

“…Despite recent clinical successes for irreversible drugs, potential toxicities mediated by unpredictable modification of off-target cysteines represents a…”
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Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome by Rao, Suman, Gurbani, Deepak, Du, Guangyan, Everley, Robert A, Browne, Christopher M, Chaikuad, Apirat, Tan, Li, Schröder, Martin, Gondi, Sudershan, Ficarro, Scott B, Sim, Taebo, Kim, Nam Doo, Berberich, Matthew J, Knapp, Stefan, Marto, Jarrod A, Westover, Kenneth D, Sorger, Peter K, Gray, Nathanael S

“…Covalent kinase inhibitors, which typically target cysteine residues, represent an important class of clinically relevant compounds. Approximately 215 kinases…”
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Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors by Sivakumaren, Sindhu Carmen, Shim, Hyeseok, Zhang, Tinghu, Ferguson, Fleur M, Lundquist, Mark R, Browne, Christopher M, Seo, Hyuk-Soo, Paddock, Marcia N, Manz, Theresa D, Jiang, Baishan, Hao, Ming-Feng, Krishnan, Pranav, Wang, Diana G, Yang, T Jonathan, Kwiatkowski, Nicholas P, Ficarro, Scott B, Cunningham, James M, Marto, Jarrod A, Dhe-Paganon, Sirano, Cantley, Lewis C, Gray, Nathanael S

“…The PI5P4Ks have been demonstrated to be important for cancer cell proliferation and other diseases. However, the therapeutic potential of targeting these…”
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Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity by Ferguson, Fleur M, Doctor, Zainab M, Ficarro, Scott B, Browne, Christopher M, Marto, Jarrod A, Johnson, Jared L, Yaron, Tomer M, Cantley, Lewis C, Kim, Nam Doo, Sim, Taebo, Berberich, Matthew J, Kalocsay, Marian, Sorger, Peter K, Gray, Nathanael S

“…Cyclin-dependent kinase 14 (CDK14) and other TAIRE family kinases (CDKs 15-18) are proteins that lack functional annotation but are frequent off-targets of…”
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Leveraging Gas-Phase Fragmentation Pathways for Improved Identification and Selective Detection of Targets Modified by Covalent Probes by Ficarro, Scott B, Browne, Christopher M, Card, Joseph D, Alexander, William M, Zhang, Tinghu, Park, Eunyoung, McNally, Randall, Dhe-Paganon, Sirano, Seo, Hyuk-Soo, Lamberto, Ilaria, Eck, Michael J, Buhrlage, Sara J, Gray, Nathanael S, Marto, Jarrod A

“…The recent approval of covalent inhibitors for multiple clinical indications has reignited enthusiasm for this class of drugs. As interest in covalent drugs…”
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Critical Role for Saccharomyces cerevisiae Asc1p in Translational Initiation at Elevated Temperatures by Gerbasi, Vincent R., Browne, Christopher M., Samir, Parimal, Shen, Bingxin, Sun, Ming, Hazelbaker, Dane Z., Galassie, Allison C., Frank, Joachim, Link, Andrew J.

“…The eukaryotic ribosomal protein RACK1/Asc1p is localized to the mRNA exit channel of the 40S subunit but lacks a defined role in mRNA translation…”
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Targeted Identification of Protein Interactions in Eukaryotic mRNA Translation by Link, Andrew J., Niu, Xinnan, Weaver, Connie M., Jennings, Jennifer L., Duncan, Dexter T., McAfee, K. Jill, Sammons, Morgan, Gerbasi, Vince R., Farley, Adam R., Fleischer, Tracey C., Browne, Christopher M., Samir, Parimal, Galassie, Allison, Boone, Braden

“…To identify protein–protein interactions and phosphorylated amino acid sites in eukaryotic mRNA translation, replicate TAP‐MudPIT and control experiments are…”
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Front Cover: Identification of Changing Ribosome Protein Compositions using Mass Spectrometry by Samir, Parimal, Browne, Christopher M., Rahul, Sun, Ming, Shen, Bingxin, Li, Wen, Frank, Joachim, Link, Andrew J.

“…DOI: 10.1002/pmic.201800217 Eukaryotic cells contain different types of ribosomes that differ in their protein and RNA composition. The ribosome filter…”
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Abstract 2757: Discovery and characterization of covalent Pin1 inhibitors targeted to an active site cysteine by Pinch, Benika, Doctor, Zainab, Browne, Christopher M., Seo, Hyuk-Soo, Nabet, Behnam, Kozono, Shingo, Lian, Xiaolan, Zaidman, Daniel, Daitchman, Dina, London, Nir, Gong, Lu, Manz, Theresa, Chun, Yujin, Tan, Li, Marto, Jarrod, Buratowski, Stephen, Dhe-Paganon, Sirano, Zhou, Xiao, Lu, Kun Ping, Gray, Nathanael S.

“…Abstract Proline-directed phosphorylation at serine or threonine residues (pSer/Thr-Pro) regulates numerous cellular processes, including the cell cycle,…”
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Interpersonal cognitive and behavioral effects of observed anger, anxiety, and depression by Browne, Christopher M

“…Anger, like sadness and fear, has consistently been identified as a basic human emotion. Previous research has shown that individuals prefer to avoid both…”
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