Search Results - "Brown, Tracy M"

Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510) by Yang, Dewen, Xie, Zhiyong, Stephenson, Diane, Morton, Daniel, Hicks, Carol D., Brown, Tracy M., Sriram, Renuka, O'Neill, Sharon, Raunig, David, Bocan, Thomas

“…The purpose of this study was to determine if in vivo high resolution 3D MRI and localized 1H MR spectroscopy (MRS) can detect brain findings resembling…”
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Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139 by Lanz, Thomas A, Karmilowicz, Michael J, Wood, Kathleen M, Pozdnyakov, Nikolay, Du, Ping, Piotrowski, Mary A, Brown, Tracy M, Nolan, Charles E, Richter, Karl E G, Finley, James E, Fei, Qing, Ebbinghaus, Charles F, Chen, Yuhpyng L, Spracklin, Douglas K, Tate, Barbara, Geoghegan, Kieran F, Lau, Lit-Fui, Auperin, David D, Schachter, Joel B

“…LY-450139 is a gamma-secretase inhibitor shown to have efficacy in multiple cellular and animal models. Paradoxically, robust elevations of plasma amyloid-beta…”
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Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014 by Lanz, Thomas A, Wood, Kathleen M, Richter, Karl E G, Nolan, Charles E, Becker, Stacey L, Pozdnyakov, Nikolay, Martin, Barbara-Anne, Du, Ping, Oborski, Christine E, Wood, Douglas E, Brown, Tracy M, Finley, James E, Sokolowski, Sharon A, Hicks, Carol D, Coffman, Karen J, Geoghegan, Kieran F, Brodney, Michael A, Liston, Dane, Tate, Barbara

“…PF-3084014 [(S)-2-((S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide] is a…”
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Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014 by Brodney, Michael A., Auperin, David D., Becker, Stacey L., Bronk, Brian S., Brown, Tracy M., Coffman, Karen J., Finley, James E., Hicks, Carol D., Karmilowicz, Michael J., Lanz, Thomas A., Liston, Dane, Liu, Xingrong, Martin, Barbara-Anne, Nelson, Robert B., Nolan, Charles E., Oborski, Christine E., Parker, Christine P., Richter, Karl E.G., Pozdnyakov, Nikolay, Sahagan, Barbara G., Schachter, Joel B., Sokolowski, Sharon A., Tate, Barbara, Wood, Douglas E., Wood, Kathleen M., Van Deusen, Jeffrey W., Zhang, Lei

“…A novel series of tetralin containing amino imidazoles, derived from modification of the corresponding phenyl acetic acid derivatives is described. Replacement…”
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Peripheral elevation of IGF-1 fails to alter Aβ clearance in multiple in vivo models by Lanz, Thomas A., Salatto, Christopher T., Semproni, Anthony R., Marconi, Michael, Brown, Tracy M., Richter, Karl E.G., Schmidt, Kari, Nelson, Frederick R., Schachter, Joel B.

“…Increasing beta-amyloid (Aβ) clearance may alter the course of Alzheimer's disease progression and attenuate amyloid plaque pathology. Insulin-like growth…”
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Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer’s disease by Brodney, Michael A., Auperin, David D., Becker, Stacey L., Bronk, Brian S., Brown, Tracy M., Coffman, Karen J., Finley, James E., Hicks, Carol D., Karmilowicz, Michael J., Lanz, Thomas A., Liston, Dane, Liu, Xingrong, Martin, Barbara-Anne, Nelson, Robert B., Nolan, Charles E., Oborski, Christine E., Parker, Christine P., Richter, Karl E.G., Pozdnyakov, Nikolay, Sahagan, Barbara G., Schachter, Joel B., Sokolowski, Sharon A., Tate, Barbara, Van Deusen, Jeffrey W., Wood, Douglas E., Wood, Kathleen M.

“…The synthesis and structure–activity relationship (SAR) of a novel series of di-substituted imidazoles, derived from modification of DAPT, are described…”
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Common pathways and cellular processes as revealed by computational analysis of expression patterns from Tg4510 mice and human Alzheimer brains by Zagouras, Panayiotis, Poland, Bradley W, Naik, Snehal, Kawabe, Thomas T, Brown, Tracy M, Peitzsch, Robert M, Hicks, Carol D, Milici, Anthony J

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Overexpression of human tau induces loss of synaptic markers and requires phosphorylation of tau in the microtubule binding domain by Hicks, Carol D, Brown, Tracy M, Kimmel, Lida H, Kleiman, Robin J, Richter, Karl E.G, Loos, Paula

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Transgene dependent, doxycycline-sensitive cognitive deficits in Tg4510 mutant mouse correlate with insoluble tau epitope accumulation by Roof, Robin L, Yabe, Yoko, Brown, Tracy M, McCarthy, Sheryl A, Bales, Kelly R, Hicks, Carol D

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Characterization of rTg4510 mice yields evidence of significant neuroinflammation by Robshaw, Ashley E, Kawabe, Thomas T, Caouette, David, Brown, Tracy M, Soares, Holly D, Hicks, Carol D, Milici, Anthony J, JoAnn Dumin

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P1‐146: Transgene dependent, doxycycline‐sensitive cognitive deficits in Tg4510 mutant mouse correlate with insoluble tau epitope accumulation by Roof, Robin L., Yabe, Yoko, Brown, Tracy M., McCarthy, Sheryl A., Bales, Kelly R., Hicks, Carol D.

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P1‐337: Overexpression of human tau induces loss of synaptic markers and requires phosphorylation of tau in the microtubule binding domain by Hicks, Carol D., Brown, Tracy M., Kimmel, Lida H., Kleiman, Robin J., Richter, Karl E.G., Loos, Paula

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P1‐163: Characterization of rTg4510 mice yields evidence of significant neuroinflammation by Robshaw, Ashley E., Kawabe, Thomas T., Caouette, David, Brown, Tracy M., Soares, Holly D., Hicks, Carol D., Milici, Anthony J., JoAnn Dumin

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P1‐140: Common pathways and cellular processes as revealed by computational analysis of expression patterns from Tg4510 mice and human Alzheimer brains by Zagouras, Panayiotis, Poland, Bradley W., Naik, Snehal, Kawabe, Thomas T., Brown, Tracy M., Peitzsch, Robert M., Hicks, Carol D., Milici, Anthony J.

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Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models by Lanz, Thomas A, Salatto, Christopher T, Semproni, Anthony R, Marconi, Michael, Brown, Tracy M, Richter, Karl E G, Schmidt, Kari, Nelson, Frederick R, Schachter, Joel B

“…Increasing beta-amyloid (Abeta) clearance may alter the course of Alzheimer's disease progression and attenuate amyloid plaque pathology. Insulin-like growth…”
Get full text