Search Results - "Brown, Steven A."

Circadian Metabolism: From Mechanisms to Metabolomics and Medicine by Brown, Steven A

“…The circadian clock directs nearly all aspects of diurnal physiology, including metabolism. Current research identifies several major axes by which it exerts…”
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Circadian clock-mediated control of stem cell division and differentiation: beyond night and day by Brown, Steven A

“…A biological 'circadian' clock conveys diurnal regulation upon nearly all aspects of behavior and physiology to optimize them within the framework of the solar…”
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(Re)inventing the Circadian Feedback Loop by Brown, Steven A., Kowalska, Elzbieta, Dallmann, Robert

“…For 20 years, researchers have thought that circadian clocks are defined by feedback loops of transcription and translation. The rediscovery of…”
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Chronopharmacology: new insights and therapeutic implications by Dallmann, Robert, Brown, Steven A, Gachon, Frédéric

“…Most facets of mammalian physiology and behavior vary according to time of day, thanks to endogenous circadian clocks. Therefore, it is not surprising that…”
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The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep by Noya, Sara B, Colameo, David, Brüning, Franziska, Spinnler, Andrea, Mircsof, Dennis, Opitz, Lennart, Mann, Matthias, Tyagarajan, Shiva K, Robles, Maria S, Brown, Steven A

“…Neurons have adapted mechanisms to traffic RNA and protein into distant dendritic and axonal arbors. Taking a biochemical approach, we reveal that forebrain…”
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Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics by Schmitt, Karen, Grimm, Amandine, Dallmann, Robert, Oettinghaus, Bjoern, Restelli, Lisa Michelle, Witzig, Melissa, Ishihara, Naotada, Mihara, Katsuyoshi, Ripperger, Jürgen A., Albrecht, Urs, Frank, Stephan, Brown, Steven A., Eckert, Anne

“…Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative phosphorylation and generation of ATP, are strongly…”
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Sleep-wake cycles drive daily dynamics of synaptic phosphorylation by Brüning, Franziska, Noya, Sara B, Bange, Tanja, Koutsouli, Stella, Rudolph, Jan D, Tyagarajan, Shiva K, Cox, Jürgen, Mann, Matthias, Brown, Steven A, Robles, Maria S

“…The circadian clock drives daily changes of physiology, including sleep-wake cycles, through regulation of transcription, protein abundance, and function…”
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human circadian metabolome by Dallmann, Robert, Viola, Antoine U, Tarokh, Leila, Cajochen, Christian, Brown, Steven A

“…The circadian clock orchestrates many aspects of human physiology, and disruption of this clock has been implicated in various pathologies, ranging from cancer…”
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Circadian behavior is light-reprogrammed by plastic DNA methylation by Azzi, Abdelhalim, Dallmann, Robert, Casserly, Alison, Rehrauer, Hubert, Patrignani, Andrea, Maier, Bert, Kramer, Achim, Brown, Steven A

“…In this study, the authors show that altering the photoperiod of mice results in reversible transcriptional and DNA methylation changes in the suprachiasmatic…”
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SPINDLE: End-to-end learning from EEG/EMG to extrapolate animal sleep scoring across experimental settings, labs and species by Miladinović, Đorđe, Muheim, Christine, Bauer, Stefan, Spinnler, Andrea, Noain, Daniela, Bandarabadi, Mojtaba, Gallusser, Benjamin, Krummenacher, Gabriel, Baumann, Christian, Adamantidis, Antoine, Brown, Steven A, Buhmann, Joachim M

“…Understanding sleep and its perturbation by environment, mutation, or medication remains a central problem in biomedical research. Its examination in animal…”
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Circadian VIPergic Neurons of the Suprachiasmatic Nuclei Sculpt the Sleep-Wake Cycle by Collins, Ben, Pierre-Ferrer, Sara, Muheim, Christine, Lukacsovich, David, Cai, Yuchen, Spinnler, Andrea, Herrera, Carolina Gutierrez, Wen, Shao’Ang, Winterer, Jochen, Belle, Mino D.C., Piggins, Hugh D., Hastings, Michael, Loudon, Andrew, Yan, Jun, Földy, Csaba, Adamantidis, Antoine, Brown, Steven A.

“…Although the mammalian rest-activity cycle is controlled by a “master clock” in the suprachiasmatic nucleus (SCN) of the hypothalamus, it is unclear how firing…”
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NONO couples the circadian clock to the cell cycle by Kowalska, Elzbieta, Ripperger, Juergen A., Hoegger, Dominik C., Bruegger, Pascal, Buch, Thorsten, Birchler, Thomas, Mueller, Anke, Albrecht, Urs, Contaldo, Claudio, Brown, Steven A.

“…Mammalian circadian clocks restrict cell proliferation to defined time windows, but the mechanism and consequences of this interrelationship are not fully…”
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Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice by Jagannath, Aarti, Varga, Norbert, Dallmann, Robert, Rando, Gianpaolo, Gosselin, Pauline, Ebrahimjee, Farid, Taylor, Lewis, Mosneagu, Dragos, Stefaniak, Jakub, Walsh, Steven, Palumaa, Teele, Di Pretoro, Simona, Sanghani, Harshmeena, Wakaf, Zeinab, Churchill, Grant C., Galione, Antony, Peirson, Stuart N., Boison, Detlev, Brown, Steven A., Foster, Russell G., Vasudevan, Sridhar R.

“…The accumulation of adenosine is strongly correlated with the need for sleep and the detection of sleep pressure is antagonised by caffeine. Caffeine also…”
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Circadian variation of the human metabolome captured by real-time breath analysis by Martinez-Lozano Sinues, Pablo, Tarokh, Leila, Li, Xue, Kohler, Malcolm, Brown, Steven A, Zenobi, Renato, Dallmann, Robert

“…Circadian clocks play a significant role in the correct timing of physiological metabolism, and clock disruption might lead to pathological changes of…”
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Network Dynamics Mediate Circadian Clock Plasticity by Azzi, Abdelhalim, Evans, Jennifer A., Leise, Tanya, Myung, Jihwan, Takumi, Toru, Davidson, Alec J., Brown, Steven A.

“…A circadian clock governs most aspects of mammalian behavior. Although its properties are in part genetically determined, altered light-dark environment can…”
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Measuring circadian clock function in human cells by Gaspar, Ludmila, Brown, Steven A

“…Circadian clocks are present in most cells and are essential for maintenance of daily rhythms in physiology, mood, and cognition. Thus, not only neurons of the…”
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Roughness and dynamics of proliferating cell fronts as a probe of cell–cell interactions by Rapin, Guillaume, Caballero, Nirvana, Gaponenko, Iaroslav, Ziegler, Benedikt, Rawleigh, Audrey, Moriggi, Ermanno, Giamarchi, Thierry, Brown, Steven A., Paruch, Patrycja

“…Juxtacellular interactions play an essential but still not fully understood role in both normal tissue development and tumour invasion. Using proliferating…”
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Human peripheral clocks: applications for studying circadian phenotypes in physiology and pathophysiology by Saini, Camille, Brown, Steven A, Dibner, Charna

“…Most light-sensitive organisms on earth have acquired an internal system of circadian clocks allowing the anticipation of light or darkness. In humans, the…”
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A phosphate transporter in VIPergic neurons of the suprachiasmatic nucleus gates locomotor activity during the light/dark transition in mice by Pierre-Ferrer, Sara, Collins, Ben, Lukacsovich, David, Wen, Shao’Ang, Cai, Yuchen, Winterer, Jochen, Yan, Jun, Pedersen, Lene, Földy, Csaba, Brown, Steven A.

“…The suprachiasmatic nucleus (SCN) encodes time of day through changes in daily firing; however, the molecular mechanisms by which the SCN times behavior are…”
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Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath by Li, Xue, Martinez-Lozano Sinues, Pablo, Dallmann, Robert, Bregy, Lukas, Hollmén, Maija, Proulx, Steven, Brown, Steven A., Detmar, Michael, Kohler, Malcolm, Zenobi, Renato

“…Noninvasive, real‐time pharmacokinetic (PK) monitoring of ketamine, propofol, and valproic acid, and their metabolites was achieved in mice, using secondary…”
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