Search Results - "Brown, Simon H J"

A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage by Brown, Simon H J, Eather, Samuel R, Freeman, Dilys J, Meyer, Barbara J, Mitchell, Todd W

“…In preeclampsia, maternal insulin resistance leads to defective expansion of adipocytes, enhanced adipocyte lipolysis, up-regulation of very low density…”
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Molecular basis for RNA polymerase-dependent transcription complex recycling by the helicase-like motor protein HelD by Newing, Timothy P., Oakley, Aaron J., Miller, Michael, Dawson, Catherine J., Brown, Simon H. J., Bouwer, James C., Tolun, Gökhan, Lewis, Peter J.

“…In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to…”
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Structural basis of promiscuous substrate transport by Organic Cation Transporter 1 by Zeng, Yi C., Sobti, Meghna, Quinn, Ada, Smith, Nicola J., Brown, Simon H. J., Vandenberg, Jamie I., Ryan, Renae M., O’Mara, Megan L., Stewart, Alastair G.

“…Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations…”
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Variation in structural motifs within SARS-related coronavirus spike proteins by Hills, Francesca R, Eruera, Alice-Roza, Hodgkinson-Bean, James, Jorge, Fátima, Easingwood, Richard, Brown, Simon H J, Bouwer, James C, Li, Yi-Ping, Burga, Laura N, Bostina, Mihnea

“…SARS-CoV-2 is the third known coronavirus (CoV) that has crossed the animal-human barrier in the last two decades. However, little structural information…”
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Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients by Rouet, Romain, Henry, Jake Y., Johansen, Matt D., Sobti, Meghna, Balachandran, Harikrishnan, Langley, David B., Walker, Gregory J., Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Mazigi, Ohan, Schofield, Peter, Burnett, Deborah L., Brown, Simon H. J., Martinello, Marianne, Hudson, Bernard, Gilroy, Nicole, Post, Jeffrey J., Kelleher, Anthony, Jäck, Hans-Martin, Goodnow, Christopher C., Turville, Stuart G., Rawlinson, William D., Bull, Rowena A., Stewart, Alastair G., Hansbro, Philip M., Christ, Daniel

“…Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-2 monoclonal antibodies and vaccines currently used in clinical…”
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Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli by Xu, Zhi-Qiang, Jergic, Slobodan, Lo, Allen T. Y., Pradhan, Alok C., Brown, Simon H. J., Bouwer, James C., Ghodke, Harshad, Lewis, Peter J., Tolun, Gökhan, Oakley, Aaron J., Dixon, Nicholas E.

“…Ring-shaped DNA sliding clamps are essential for DNA replication and genome maintenance. Clamps need to be opened and chaperoned onto DNA by clamp loader…”
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Changes in lipid composition during sexual development of the malaria parasite Plasmodium falciparum by Tran, Phuong N, Brown, Simon H J, Rug, Melanie, Ridgway, Melanie C, Mitchell, Todd W, Maier, Alexander G

“…The development of differentiated sexual stages (gametocytes) within human red blood cells is essential for the propagation of the malaria parasite, since only…”
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An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids by Abbott, Sarah K., Jenner, Andrew M., Mitchell, Todd W., Brown, Simon H. J., Halliday, Glenda M., Garner, Brett

“…We have developed a protocol suitable for high-throughput lipidomic analysis of human brain samples. The traditional Folch extraction (using chloroform and…”
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Cholesteryl ester levels are elevated in the caudate and putamen of Huntington’s disease patients by Phillips, Gabrielle R., Hancock, Sarah E., Brown, Simon H. J., Jenner, Andrew M., Kreilaus, Fabian, Newell, Kelly A., Mitchell, Todd W.

“…Huntington’s disease (HD) is an autosomal dominant neurodegenerative illness caused by a mutation in the huntingtin gene (HTT) and subsequent protein (mhtt),…”
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Changes within the central stalk of E. coli F1Fo ATP synthase observed after addition of ATP by Sobti, Meghna, Zeng, Yi C., Walshe, James L., Brown, Simon H. J., Ishmukhametov, Robert, Stewart, Alastair G.

“…F 1 F o ATP synthase functions as a biological generator and makes a major contribution to cellular energy production. Proton flow generates rotation in the F…”
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Time to Face the Fats: What Can Mass Spectrometry Reveal about the Structure of Lipids and Their Interactions with Proteins? by Brown, Simon H. J., Mitchell, Todd W., Oakley, Aaron J., Pham, Huong T., Blanksby, Stephen J.

“…Since the 1950s, X-ray crystallography has been the mainstay of structural biology, providing detailed atomic-level structures that continue to revolutionize…”
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ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs by Athanasopoulos, Vicki, Barker, Andrew, Yu, Di, Tan, Andy H.M, Srivastava, Monika, Contreras, Nelida, Wang, Jianbin, Lam, Kong-Peng, Brown, Simon H.J, Goodnow, Christopher C, Dixon, Nicholas E, Leedman, Peter J, Saint, Robert, Vinuesa, Carola G

“…Roquin is an E3 ubiquitin ligase with a poorly understood but essential role in preventing T-cell-mediated autoimmune disease and in microRNA-mediated…”
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A comparison of patient matched meibum and tear lipidomes by Brown, Simon H J, Kunnen, Carolina M E, Duchoslav, Eva, Dolla, Naveen K, Kelso, Michael J, Papas, Eric B, Lazon de la Jara, Percy, Willcox, Mark D P, Blanksby, Stephen J, Mitchell, Todd W

“…To quantify the molecular lipid composition of patient-matched tear and meibum samples and compare tear and meibum lipid molecular profiles. Lipids were…”
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Regulation of mitochondrial metabolism in murine skeletal muscle by the medium‐chain fatty acid receptor Gpr84 by Montgomery, Magdalene K., Osborne, Brenna, Brandon, Amanda E., O'Reilly, Liam, Fiveash, Corrine E., Brown, Simon H. J., Wilkins, Brendan P., Samsudeen, Azrah, Yu, Josephine, Devanapalli, Beena, Hertzog, Ashley, Tolun, Adviye A., Kavanagh, Tomas, Cooper, Antony A., Mitchell, Todd W., Biden, Trevor J., Smith, Nicola J., Cooney, Gregory J., Turner, Nigel

“…Fatty acid receptors have been recognized as important players in glycaemic control. This study is the first to describe a role for the medium‐chain fatty acid…”
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Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids by Hancock, Sarah E., Ailuri, Ramesh, Marshall, David L., Brown, SimonH.J., Saville, Jennifer T., Narreddula, Venkateswara R., Boase, Nathan R., Poad, BerwyckL.J., Trevitt, Adam J., Willcox, MarkD.P., Kelso, Michael J., Mitchell, Todd W., Blanksby, Stephen J.

“…The (O-acyl)-ω-hydroxy FAs (OAHFAs) comprise an unusual lipid subclass present in the skin, vernix caseosa, and meibomian gland secretions. Although they are…”
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A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite by Tran, Phuong N., Brown, Simon H. J., Mitchell, Todd W., Matuschewski, Kai, McMillan, Paul J., Kirk, Kiaran, Dixon, Matthew W. A., Maier, Alexander G.

“…ATP-binding cassette (ABC) transporters serve a variety of physiological functions as well as play key roles in drug resistance. The genome of the human…”
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Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis by Srivastava, Monika, Duan, Guowen, Kershaw, Nadia J., Athanasopoulos, Vicki, Yeo, Janet H. C., Ose, Toyoyuki, Hu, Desheng, Brown, Simon H. J., Jergic, Slobodan, Patel, Hardip R., Pratama, Alvin, Richards, Sashika, Verma, Anil, Jones, E. Yvonne, Heissmeyer, Vigo, Preiss, Thomas, Dixon, Nicholas E., Chong, Mark M. W., Babon, Jeffrey J., Vinuesa, Carola G.

“…Roquin is an RNA-binding protein that prevents autoimmunity and inflammation via repression of bound target mRNAs such as inducible costimulator ( Icos ). When…”
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HDX‐MS reveals orthosteric and allosteric changes in apolipoprotein‐D structural dynamics upon binding of progesterone by Kielkopf, Claudia S., Ghosh, Madhubrata, Anand, Ganesh S., Brown, Simon H.J.

“…Apolipoprotein‐D is a glycosylated tetrameric lipocalin that binds and transports small hydrophobic molecules such as progesterone and arachidonic acid. Like…”
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The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine‐expressing myeloma cells by Vuckovic, Slavica, Vandyke, Kate, Rickards, David A., McCauley Winter, Padraig, Brown, Simon H. J., Mitchell, Todd W., Liu, Jun, Lu, Jun, Askenase, Philip W., Yuriev, Elizabeth, Capuano, Ben, Ramsland, Paul A., Hill, Geoffrey R., Zannettino, Andrew C. W., Hutchinson, Andrew T.

“…Summary We have discovered that a small cationic molecule, GW4869, is cytotoxic to a subset of myeloma cell lines and primary myeloma plasma cells. Biochemical…”
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The long and the short of Huntington’s disease: how the sphingolipid profile is shifted in the caudate of advanced clinical cases by Phillips, Gabrielle R., Saville, Jennifer T., Hancock, Sarah E., Brown, Simon H. J., Jenner, Andrew M., McLean, Catriona, Fuller, Maria, Newell, Kelly A., Mitchell, Todd W.

“…Abstract Huntington’s disease is a devastating neurodegenerative disorder that onsets in late adulthood as progressive and terminal cognitive, psychiatric and…”
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