Search Results - "Brown, Rogers M."

Where hearing starts: the development of the mammalian cochlea by Basch, Martin L., Brown, Rogers M., Jen, Hsin‐I, Groves, Andrew K.

“…The mammalian cochlea is a remarkable sensory organ, capable of perceiving sound over a range of 1012 in pressure, and discriminating both infrasonic and…”
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Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates by Basch, Martin L, Brown, 2nd, Rogers M, Jen, Hsin-I, Semerci, Fatih, Depreux, Frederic, Edlund, Renée K, Zhang, Hongyuan, Norton, Christine R, Gridley, Thomas, Cole, Susan E, Doetzlhofer, Angelika, Maletic-Savatic, Mirjana, Segil, Neil, Groves, Andrew K

“…The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, and are…”
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Notch-mediated lateral induction is necessary to maintain vestibular prosensory identity during inner ear development by Brown, Rogers M., Nelson, Joel C., Zhang, Hongyuan, Kiernan, Amy E., Groves, Andrew K.

“…The five vestibular organs of the inner ear derive from patches of prosensory cells that express the transcription factor SOX2 and the Notch ligand JAG1…”
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Lineage tracing of Sox2-expressing progenitor cells in the mouse inner ear reveals a broad contribution to non-sensory tissues and insights into the origin of the organ of Corti by Gu, Rende, Brown, Rogers M., Hsu, Chih-Wei, Cai, Tiantian, Crowder, Alyssa L., Piazza, Victor G., Vadakkan, Tegy J., Dickinson, Mary E., Groves, Andrew K.

“…The transcription factor Sox2 is both necessary and sufficient for the generation of sensory regions of the inner ear. It regulates expression of the Notch…”
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