Search Results - "Brown, Richard C. D."

Flow Electrolysis Cells for the Synthetic Organic Chemistry Laboratory by Pletcher, Derek, Green, Robert A, Brown, Richard C. D

“…Electrosynthesis has much to offer to the synthetic organic chemist. But in order to be widely accepted as a routine procedure in an organic synthesis…”
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N‑Heterocyclic Carbene-Mediated Microfluidic Oxidative Electrosynthesis of Amides from Aldehydes by Green, Robert A, Pletcher, Derek, Leach, Stuart G, Brown, Richard C. D

“…A flow process for N-Heterocyclic Carbene (NHC)-mediated anodic oxidative amidation of aldehydes is described, employing an undivided microfluidic electrolysis…”
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N‑Heterocyclic Carbene-Mediated Oxidative Electrosynthesis of Esters in a Microflow Cell by Green, Robert A, Pletcher, Derek, Leach, Stuart G, Brown, Richard C. D

“…An efficient N-heterocyclic carbene (NHC)-mediated oxidative esterification of aldehydes has been achieved in an undivided microfluidic electrolysis cell at…”
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A Nuclear Singlet Lifetime of More than One Hour in Room-Temperature Solution by Stevanato, Gabriele, Hill-Cousins, Joseph T., Håkansson, Pär, Roy, Soumya Singha, Brown, Lynda J., Brown, Richard C. D., Pileio, Giuseppe, Levitt, Malcolm H.

“…Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are supremely important techniques with numerous applications in almost all branches of…”
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Recycling and Imaging of Nuclear Singlet Hyperpolarization by Pileio, Giuseppe, Bowen, Sean, Laustsen, Christoffer, Tayler, Michael C. D, Hill-Cousins, Joseph T, Brown, Lynda J, Brown, Richard C. D, Ardenkjaer-Larsen, Jan H, Levitt, Malcolm H

“…The strong enhancement of NMR signals achieved by hyperpolarization decays, at best, with a time constant of a few minutes. Here, we show that a combination of…”
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Chromophore Distortions in Photointermediates of Proteorhodopsin Visualized by Dynamic Nuclear Polarization-Enhanced Solid-State NMR by Mehler, Michaela, Eckert, Carl Elias, Leeder, Alexander J, Kaur, Jagdeep, Fischer, Tobias, Kubatova, Nina, Brown, Lynda J, Brown, Richard C. D, Becker-Baldus, Johanna, Wachtveitl, Josef, Glaubitz, Clemens

“…Proteorhodopsin (PR) is the most abundant retinal protein on earth and functions as a light-driven proton pump. Despite extensive efforts, structural data for…”
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Structural Basis of the Green–Blue Color Switching in Proteorhodopsin as Determined by NMR Spectroscopy by Mao, Jiafei, Do, Nhu-Nguyen, Scholz, Frank, Reggie, Lenica, Mehler, Michaela, Lakatos, Andrea, Ong, Yean-Sin, Ullrich, Sandra J, Brown, Lynda J, Brown, Richard C. D, Becker-Baldus, Johanna, Wachtveitl, Josef, Glaubitz, Clemens

“…Proteorhodopsins (PRs) found in marine microbes are the most abundant retinal-based photoreceptors on this planet. PR variants show high levels of…”
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Total Synthesis of the Tetracyclic Lupin Alkaloid (+)-Allomatrine by Watkin, Samuel V, Camp, Nicholas P, Brown, Richard C. D

“…(+)-Allomatrine (1) has been synthesized using an imino-aldol reaction and N-acyliminium cyclization as key steps. Strategically, use of the…”
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Total Syntheses of (−) Epilupinine and (−)-Tashiromine Using Imino-Aldol Reactions by Cutter, Amanda C, Miller, Iain R, Keily, John F, Bellingham, Richard K, Light, Mark E, Brown, Richard C. D

“…Short routes to enantiomerically pure indolizidine and quinolizidine alkaloids have been developed using imino-aldol reactions of enolates derived from phenyl…”
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The synthesis of biologically active indolocarbazole natural products by Chambers, George E, Sayan, A Emre, Brown, Richard C D

“…Covering: up to 2020The indolocarbazoles, in particular indolo[2,3- ]pyrrolo[3,4- ]carbazole derivatives, are an important class of natural products that…”
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Stereocontrolled Synthesis of (−)-Galanthamine by Satcharoen, Vachiraporn, McLean, Neville J, Kemp, Stephen C, Camp, Nicholas P, Brown, Richard C. D

“…An enantioselective synthesis of (−)-galanthamine has been realized in 11 linear steps starting from isovanillin. A Mitsunobu aryl ether forming reaction was…”
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trans-2-Tritylcyclohexanol as a Chiral Auxiliary in Permanganate-Mediated Oxidative Cyclization of 2‑Methylenehept-5-enoates: Application to the Synthesis of trans-(+)-Linalool Oxide by Al Hazmi, Ali M, Sheikh, Nadeem S, Bataille, Carole J. R, Al-Hadedi, Azzam A. M, Watkin, Sam V, Luker, Tim J, Camp, Nicholas P, Brown, Richard C. D

“…The permanganate-mediated oxidative cyclization of a series of 2-methylenehept-5-eneoates bearing different chiral auxiliaries was investigated, leading to the…”
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Enlightening the photoactive site of channelrhodopsin-2 by DNP-enhanced solid-state NMR spectroscopy by Becker-Baldus, Johanna, Bamann, Christian, Saxena, Krishna, Gustmann, Henrik, Brown, Lynda J., Brown, Richard C. D., Reiter, Christian, Bamberg, Ernst, Wachtveitl, Josef, Schwalbe, Harald, Glaubitz, Clemens

“…Channelrhodopsin-2 fromChlamydomonas reinhardtiiis a light-gated ion channel. Over recent years, this ion channel has attracted considerable interest because…”
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Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents by Santoni, Gianluca, de Sousa, Julien, de la Mora, Eugenio, Dias, José, Jean, Ludovic, Sussman, Joel L, Silman, Israel, Renard, Pierre-Yves, Brown, Richard C. D, Weik, Martin, Baati, Rachid, Nachon, Florian

“…Acetylcholinesterase (AChE), a key enzyme in the central and peripheral nervous systems, is the principal target of organophosphorus nerve agents. Quaternary…”
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A Resin-Linker-Vector Approach to Radiopharmaceuticals Containing 18F: Application in the Synthesis of O-(2-[18F]-Fluoroethyl)-L-tyrosine by Topley, Amy C., Isoni, Valerio, Logothetis, Thomas A., Wynn, Duncan, Wadsworth, Harry, Gibson, Alex M. R., Khan, Imtiaz, Wells, Neil J., Perrio, Cécile, Brown, Richard C. D.

“…A Resin‐linker‐vector (RLV) strategy is described for the radiosynthesis of tracer molecules containing the radionuclide 18F, which releases the labelled…”
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A Microflow Electrolysis Cell for Laboratory Synthesis on the Multigram Scale by Green, Robert A, Brown, Richard C. D, Pletcher, Derek, Harji, Bashir

“…A large microflow electrolysis cell for laboratory synthesis on a multigram scale is described. It is based on two circular electrodes with a diameter of 149…”
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Oxidative Cyclization Reactions of Trienes and Dienynes: Total Synthesis of Membrarollin by Morris, Claire L, Hu, Yulai, Head, Geoff D, Brown, Lynda J, Whittingham, William G, Brown, Richard C. D

“…Trienes and dienynes containing one electron-deficient double bond were shown to undergo regio- and stereoselective oxidative cyclization in the presence of…”
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Long-Lived Nuclear Spin States in Methyl Groups and Quantum-Rotor-Induced Polarization by Meier, Benno, Dumez, Jean-Nicolas, Stevanato, Gabriele, Hill-Cousins, Joseph T, Roy, Soumya Singha, Håkansson, Pär, Mamone, Salvatore, Brown, Richard C. D, Pileio, Giuseppe, Levitt, Malcolm H

“…Substances containing rapidly rotating methyl groups may exhibit long-lived states (LLSs) in solution, with relaxation times substantially longer than the…”
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Exploring Protein Structures by DNP-Enhanced Methyl Solid-State NMR Spectroscopy by Mao, Jiafei, Aladin, Victoria, Jin, Xinsheng, Leeder, Alexander J, Brown, Lynda J, Brown, Richard C. D, He, Xiao, Corzilius, Björn, Glaubitz, Clemens

“…Although the rapid development of sensitivity-enhanced solid-state NMR (ssNMR) spectroscopy based on dynamic nuclear polarization (DNP) has enabled a broad…”
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Transition-Metal-Mediated Chemo- and Stereoselective Total Synthesis of (−)-Galanthamine by Miller, Iain R, McLean, Neville J, Moustafa, Gamal A. I, Ajavakom, Vachiraporn, Kemp, Stephen C, Bellingham, Richard K, Camp, Nicholas P, Brown, Richard C. D

“…An asymmetric synthetic route to (−)-galanthamine (1), a pharmacologically active Amaryllidaceae alkaloid used for the symptomatic treatment of early onset…”
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