Search Results - "Brown, R Clark"

A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease by Vichinsky, Elliott, Hoppe, Carolyn C, Ataga, Kenneth I, Ware, Russell E, Nduba, Videlis, El-Beshlawy, Amal, Hassab, Hoda, Achebe, Maureen M, Alkindi, Salam, Brown, R. Clark, Diuguid, David L, Telfer, Paul, Tsitsikas, Dimitris A, Elghandour, Ashraf, Gordeuk, Victor R, Kanter, Julie, Abboud, Miguel R, Lehrer-Graiwer, Joshua, Tonda, Margaret, Intondi, Allison, Tong, Barbara, Howard, Jo

“…In a trial evaluating two daily-dose levels of voxelotor, which binds to sickle hemoglobin and prevents polymerization under hypoxic conditions, hemoglobin…”
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A clinician’s view of voxelotor by Osunkwo, Ifeyinwa, Anderson, Alan, Brown, R. Clark, Shah, Nirmish, Estepp, Jeremie H.

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Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG) by Wang, Winfred C, Prof, Ware, Russell E, Prof, Miller, Scott T, Prof, Iyer, Rathi V, Prof, Casella, James F, Prof, Minniti, Caterina P, MD, Rana, Sohail, Prof, Thornburg, Courtney D, MD, Rogers, Zora R, Prof, Kalpatthi, Ram V, MD, Barredo, Julio C, Prof, Brown, R Clark, MD, Sarnaik, Sharada A, Prof, Howard, Thomas H, Prof, Wynn, Lynn W, MSN, Kutlar, Abdullah, Prof, Armstrong, F Daniel, Prof, Files, Beatrice A, MD, Goldsmith, Jonathan C, MD, Waclawiw, Myron A, PhD, Huang, Xiangke, MD, Thompson, Bruce W, PhD

“…Summary Background Sickle-cell anaemia is associated with substantial morbidity from acute complications and organ dysfunction beginning in the first year of…”
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Whole-exome sequencing for RH genotyping and alloimmunization risk in children with sickle cell anemia by Chou, Stella T., Flanagan, Jonathan M., Vege, Sunitha, Luban, Naomi L.C., Brown, R. Clark, Ware, Russell E., Westhoff, Connie M.

“…RH genes are highly polymorphic and encode the most complex of the 35 human blood group systems. This genetic diversity contributes to Rh alloimmunization in…”
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Consensus definition of essential, optimal, and suggested components of a pediatric sickle cell disease center by Hulbert, Monica L., Manwani, Deepa, Meier, Emily Riehm, Alvarez, Ofelia A., Brown, R. Clark, Callaghan, Michael U., Campbell, Andrew D., Coates, Thomas D., Frei‐Jones, Melissa J., Hankins, Jane S., Heeney, Matthew M., Hsu, Lewis L., Lebensburger, Jeffrey D., Quinn, Charles T., Shah, Nirmish, Smith‐Whitley, Kim, Thornburg, Courtney, Kanter, Julie

“…Sickle cell disease (SCD) requires coordinated, specialized medical care for optimal outcomes. There are no United States (US) guidelines that define a…”
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Quantifying the Cerebral Hemometabolic Response to Blood Transfusion in Pediatric Sickle Cell Disease With Diffuse Optical Spectroscopies by Lee, Seung Yup, Brothers, Rowan O., Turrentine, Katherine B., Quadri, Ayesha, Sathialingam, Eashani, Cowdrick, Kyle R., Gillespie, Scott, Bai, Shasha, Goldman-Yassen, Adam E., Joiner, Clinton H., Brown, R. Clark, Buckley, Erin M.

“…Red blood cell transfusions are common in patients with sickle cell disease who are at increased risk of stroke. Unfortunately, transfusion thresholds needed…”
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The effects of hydroxyurea and bone marrow transplant on Anti-Müllerian hormone (AMH) levels in females with sickle cell anemia by Elchuri, Swati V., Williamson, Rebecca S., Clark Brown, R., Haight, Ann E., Spencer, Jessica B., Buchanan, Iris, Hassen-Schilling, Leann, Brown, Milton R., Mertens, Ann C., Meacham, Lillian R.

“…Gonadal hypofunction is described in male and female patients with sickle cell anemia (SCA) after bone marrow transplant (BMT) and in males treated with…”
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Towards an Effective Patient Health Engagement System Using Cloud-Based Text Messaging Technology by Cheng, Chih-Wen, Brown, Clark R., Venugopalan, Janani, Wang, May D.

“…Patient and health provider interaction via text messaging (TM) has become an accepted form of communication, often favored by adolescents and young adults…”
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Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia—TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial by Ware, Russell E, Prof, Davis, Barry R, Prof, Schultz, William H, MHS PA, Brown, R Clark, MD PhD, Aygun, Banu, MD, Sarnaik, Sharada, Prof, Odame, Isaac, Prof, Fuh, Beng, MD, George, Alex, MD PhD, Owen, William, MD, Luchtman-Jones, Lori, Prof, Rogers, Zora R, Prof, Hilliard, Lee, Prof, Gauger, Cynthia, MD, Piccone, Connie, MD, Lee, Margaret T, MD, Kwiatkowski, Janet L, MD MSCE, Jackson, Sherron, MD, Miller, Scott T, Prof, Roberts, Carla, MD, Heeney, Matthew M, MD, Kalfa, Theodosia A, MD PhD, Nelson, Stephen, MD, Imran, Hamayun, MD, Nottage, Kerri, MD MPH, Alvarez, Ofelia, Prof, Rhodes, Melissa, MD, Thompson, Alexis A, Prof, Rothman, Jennifer A, MD, Helton, Kathleen J, MD, Roberts, Donna, MD, Coleman, Jamie, MD, Bonner, Melanie J, Prof, Kutlar, Abdullah, Prof, Patel, Niren, MD, Wood, John, MD PhD, Piller, Linda, MD, Wei, Peng, PhD, Luden, Judy, CCRC, Mortier, Nicole A, MHS PA-C, Stuber, Susan E, MA, Luban, Naomi L C, Prof, Cohen, Alan R, Prof, Pressel, Sara, MS, Adams, Robert J, Prof

“…Summary Background For children with sickle cell anaemia and high transcranial doppler (TCD) flow velocities, regular blood transfusions can effectively…”
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A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis by Dampier, Carlton D., Telen, Marilyn Jo, Wun, Ted, Brown, R. Clark, Desai, Payal, El Rassi, Fuad, Fuh, Beng, Kanter, Julie, Pastore, Yves, Rothman, Jennifer, Taylor, James G., Readett, David, Sivamurthy, Krupa M., Tammara, Brinda, Tseng, Li-Jung, Lozier, Jay Nelson, Thackray, Helen, Magnani, John L., Hassell, Kathryn L.

“…•Rivipansel was safe and well-tolerated in sickle cell patients hospitalized for VOC, but did not meet primary or secondary end points.•Rivipansel use early in…”
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The influence of voxelotor on cerebral blood flow and oxygen extraction in pediatric sickle cell disease by Brothers, Rowan O., Turrentine, Katherine B., Akbar, Mariam, Triplett, Sydney, Zhao, Hongting, Urner, Tara M., Goldman-Yassen, Adam, Jones, Richard A., Knight-Scott, Jack, Milla, Sarah S., Bai, Shasha, Tang, Amy, Brown, R. Clark, Buckley, Erin M.

“…•Optical measurements of cerebral blood flow are validated against perfusion MRI in pediatric SCA.•Voxelotor significantly decreases OEF and cerebral blood…”
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Distinct Domains of Erythroid Krüppel-Like Factor Modulate Chromatin Remodeling and Transactivation at the Endogenous β-Globin Gene Promoter by Brown, R Clark, Pattison, Scott, van Ree, Janine, Coghill, Elise, Perkins, Andrew, Jane, Stephen M, Cunningham, John M

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Effects of hydroxyurea treatment for patients with hemoglobin SC disease by Luchtman‐Jones, Lori, Pressel, Sara, Hilliard, Lee, Brown, R. Clark, Smith, Mary G., Thompson, Alexis A., Lee, Margaret T., Rothman, Jennifer, Rogers, Zora R., Owen, William, Imran, Hamayun, Thornburg, Courtney, Kwiatkowski, Janet L., Aygun, Banu, Nelson, Stephen, Roberts, Carla, Gauger, Cynthia, Piccone, Connie, Kalfa, Theodosia, Alvarez, Ofelia, Hassell, Kathryn, Davis, Barry R., Ware, Russell E.

“…Although hemoglobin SC (HbSC) disease is usually considered less severe than sickle cell anemia (SCA), which includes HbSS and HbS/β0‐thalassemia genotypes,…”
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Pharmacokinetics, pharmacodynamics, safety, and efficacy of crizanlizumab in patients with sickle cell disease by Kanter, Julie, Brown, R. Clark, Norris, Cynthia, Nair, Santosh M., Kutlar, Abdullah, Manwani, Deepa, Shah, Nirmish, Tanaka, Chiaki, Bodla, Shankaranand, Sanchez-Olle, Gessami, Albers, Urs, Liles, Darla

“…•Results from SOLACE-adults demonstrate the PK and PD properties of crizanlizumab in patients with SCD during long-term treatment.•Results also show that no…”
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Developmental function in toddlers with sickle cell anemia by Armstrong, F Daniel, Elkin, T David, Brown, R Clark, Glass, Penny, Rana, Sohail, Casella, James F, Kalpatthi, Ram V, Pavlakis, Steven, Mi, Zhibao, Wang, Winfred C

“…Neurocognitive impairment occurs in children and adults with sickle cell anemia, but little is known about neurodevelopment in very young children. We examined…”
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Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial by Wood, John C., Cohen, Alan R., Pressel, Sara L., Aygun, Banu, Imran, Hamayun, Luchtman‐Jones, Lori, Thompson, Alexis A., Fuh, Beng, Schultz, William H., Davis, Barry R., Ware, Russell E., George, Alex, Mueller, Brigitta U, Heeney, Matthew M., Kalfa, Theodosia A., Nelson, Stephen, Clark Brown, R, Gee, Beatrice, Kwiatkowski, Janet L., Smith‐Whitley, Kim, Odame, Isaac, Webb, Jennifer, Yang, Elizabeth, Lee, Margaret T., Piccone, Connie, Jackson, Sherron M., Singh, Sharon, Nottage, Kerri, Hankins, Jane S., Miller, Scott T., Hilliard, Lee, Alvarez, Ofelia, Rhodes, Melissa, Rogers, Zora R., Sarnaik, Sharada A., Owen, William C., Gauger, Cynthia, Roberts, Carla, Rothman, Jennifer A.

“…Summary Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea (TWiTCH) trial is a randomized, open‐label comparison of hydroxycarbamide (also…”
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Multicenter, phase 1 study of etavopivat (FT-4202) treatment for up to 12 weeks in patients with sickle cell disease by Saraf, Santosh L., Hagar, Robert, Idowu, Modupe, Osunkwo, Ifeyinwa, Cruz, Kimberly, Kuypers, Frans A., Brown, R. Clark, Geib, James, Ribadeneira, Maria, Schroeder, Patricia, Wu, Eric, Forsyth, Sanjeev, Kelly, Patrick F., Kalfa, Theodosia A., Telen, Marilyn J.

“…•Consistent with erythrocyte pyruvate kinase activation, adenosine triphosphate increased, and 2,3-DPG decreased with etavopivat treatment.•Clinically, this…”
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Influence of severity of anemia on clinical findings in infants with sickle cell anemia: Analyses from the BABY HUG study by Lebensburger, Jeffrey D., Miller, Scott T., Howard, Thomas H., Casella, James F., Brown, R. Clark, Lu, Ming, Iyer, Rathi V., Sarnaik, Sharada, Rogers, Zora R., Wang, Winfred C.

“…Background Clinical complications of sickle cell anemia begin in infancy. BABY HUG (ClinicalTrials.gov, NCT00006400) was a NHLBI‐NICHD supported randomized…”
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Intensive hydroxyurea dosing in very young children with sickle cell anemia by Wang, Winfred C, Brown, R Clark, McNaull, Melissa A, Rogers, Zora R, Barton, Martha, Dua, Meghna R, Hankins, Jane S, Gossett, Jeffrey, Richardson, Julie, Porter, Jerlym S, Kang, Guolian, Estepp, Jeremie H

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Organization of tcp, acf, and toxT genes within a ToxT-dependent operon by Brown, R C, Taylor, R K

“…The toxin coregulated pilus (TCP) is required for Vibrio cholerae to colonize the human intestine. The expression of the pilin gene, tcpA, is dependent upon…”
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