Search Results - "Brown, Peter J."

A 2.4% DETERMINATION OF THE LOCAL VALUE OF THE HUBBLE CONSTANT by Riess, Adam G, Macri, Lucas M, Hoffmann, Samantha L, Scolnic, Dan, Casertano, Stefano, Filippenko, Alexei V, Tucker, Brad E, Reid, Mark J, Jones, David O, Silverman, Jeffrey M, Chornock, Ryan, Challis, Peter, Yuan, Wenlong, Brown, Peter J, Foley, Ryan J

“…ABSTRACT We use the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST) to reduce the uncertainty in the local value of the Hubble constant from…”
Get full text

SOUSA: the Swift Optical/Ultraviolet Supernova Archive by Brown, Peter J., Breeveld, Alice A., Holland, Stephen, Kuin, Paul, Pritchard, Tyler

“…The Ultra-Violet Optical Telescope on the Swift spacecraft has observed hundreds of supernovae, covering all major types and most subtypes. Here we introduce…”
Get full text

Artificial Intelligence Assisted Inversion (AIAI): Quantifying the Spectral Features of 56Ni of Type Ia Supernovae by Chen, Xingzhuo, Wang, Lifan, Hu, Lei, Brown, Peter J.

“…Following our previous study of Artificial Intelligence Assisted Inversion (AIAI) of supernova analyses, we train a set of deep neural networks based on the 1D…”
Get full text

Swift Spectra of AT2018cow: A White Dwarf Tidal Disruption Event? by Kuin, N Paul M, Wu, Kinwah, Oates, Samantha, Lien, Amy, Emery, Sam, Kennea, Jamie A., Pasquale, Massimiliano de, Brown, Peter J., Tohuvavohu, Aaron, Breeveld, Alice, Burrows, David N., Cenko, S Bradley, Campana, Sergio, Levan, Andrew, Markwardt, Craig, Osborne, Julian P, Page, Mat J, Page, Kim L, Sbarufatti, Boris, Siegel, Michael, Troja, Eleonora

“…The bright transient AT2018cow has been unlike any other known type of transient. Its high brightness, rapid rise and decay, and initially nearly featureless…”
Get full text

Late-time Flattening of Type Ia Supernova Light Curves: Constraints from SN 2014J in M82 by Yang, Yi, Wang, Lifan, Baade, Dietrich, Brown, Peter. J., Cikota, Aleksandar, Cracraft, Misty, Höflich, Peter A., Maund, Justyn R., Patat, Ferdinando, Sparks, William B., Spyromilio, Jason, Stevance, Heloise F., Wang, Xiaofeng, Wheeler, J. Craig

“…The very nearby Type Ia supernova 2014J in M82 offers a rare opportunity to study the physics of thermonuclear supernovae at extremely late phases ( 800 days)…”
Get full text

SN 2012cg: EVIDENCE FOR INTERACTION BETWEEN A NORMAL SN Ia AND A NON-DEGENERATE BINARY COMPANION by Marion, G. H., Brown, Peter J., Vinkó, Jozsef, Silverman, Jeffrey M., Sand, David J., Challis, Peter, Kirshner, Robert P., Wheeler, J. Craig, Berlind, Perry, Brown, Warren R., Calkins, Michael L., Camacho, Yssavo, Dhungana, Govinda, Foley, Ryan J., Friedman, Andrew S., Graham, Melissa L., Howell, D. Andrew, Hsiao, Eric Y., Irwin, Jonathan M., Jha, Saurabh W., Kehoe, Robert, Macri, Lucas M., Maeda, Keiichi, Mandel, Kaisey, McCully, Curtis, Pandya, Viraj, Rines, Kenneth J., Wilhelmy, Steven, Zheng, Weikang

“…ABSTRACT We report evidence for excess blue light from the Type Ia supernova (Sn Ia) SN 2012cg at 15 and 16 days before maximum B-band brightness. The emission…”
Get full text

Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP by Liu, Feng, Barsyte-Lovejoy, Dalia, Li, Fengling, Xiong, Yan, Korboukh, Victoria, Huang, Xi-Ping, Allali-Hassani, Abdellah, Janzen, William P, Roth, Bryan L, Frye, Stephen V, Arrowsmith, Cheryl H, Brown, Peter J, Vedadi, Masoud, Jin, Jian

“…Among epigenetic “writers”, “readers”, and “erasers”, the lysine methyltransferases G9a and GLP, which catalyze mono- and dimethylation of histone H3 lysine 9…”
Get full text

INTERSTELLAR-MEDIUM MAPPING IN M82 THROUGH LIGHT ECHOES AROUND SUPERNOVA 2014J by Yang, Yi, Wang, Lifan, Baade, Dietrich, Brown, Peter. J., Cracraft, Misty, Höflich, Peter A., Maund, Justyn, Patat, Ferdinando, Sparks, William B., Spyromilio, Jason, Stevance, Heloise F., Wang, Xiaofeng, Wheeler, J. Craig

“…ABSTRACT We present multiple-epoch measurements of the size and surface brightness of the light echoes from supernova (SN) 2014J in the nearby starburst galaxy…”
Get full text

The Young and Nearby Normal Type Ia Supernova 2018gv: UV-optical Observations and the Earliest Spectropolarimetry by Yang, Yi, Hoeflich, Peter, Baade, Dietrich, Maund, Justyn R., Wang, Lifan, Brown, Peter. J., Stevance, Heloise F., Arcavi, Iair, Burke, Jamison, Cikota, Aleksandar, Clocchiatti, Alejandro, Gal-Yam, Avishay, Graham, Melissa. L., Hiramatsu, Daichi, Hosseinzadeh, Griffin, Howell, D. Andrew, Jha, Saurabh W., McCully, Curtis, Patat, Ferdinando, Sand, David. J., Schulze, Steve, Spyromilio, Jason, Valenti, Stefano, Vinkó, József, Wang, Xiaofeng, Wheeler, J. Craig, Yaron, Ofer, Zhang, Jujia

“…Abstract The nondetection of companion stars in SN Ia progenitor systems lends support to the notion of double-degenerate systems and explosions triggered by…”
Get full text

Connecting Infrared Surface Brightness Fluctuation Distances to Type Ia Supernova Hosts: Testing the Top Rung of the Distance Ladder by Garnavich, Peter, Wood, Charlotte M., Milne, Peter, Jensen, Joseph B., Blakeslee, John P., Brown, Peter J., Scolnic, Daniel, Rose, Benjamin, Brout, Dillon

“…Abstract We compare infrared surface brightness fluctuation (IR SBF) distances measured in galaxies that have hosted type Ia supernovae (SNe Ia) to distances…”
Get full text

Using 1991T/1999aa-like Type Ia Supernovae as Standardizable Candles by Yang, Jiawen, Wang, Lifan, Suntzeff, Nicholas, Hu, Lei, Aldoroty, Lauren, Brown, Peter J., Krisciunas, Kevin, Arcavi, Iair, Burke, Jamison, Galbany, Lluís, Hiramatsu, Daichi, Hosseinzadeh, Griffin, Howell, D. Andrew, McCully, Curtis, Pellegrino, Craig, Valenti, Stefano

“…Abstract We present the photometry of 16 91T/99aa-like Type Ia Supernovae (SNe Ia) observed by the Las Cumbres Observatory. We also use an additional set of 21…”
Get full text

SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis by Elkouris, Maximilianos, Kontaki, Haroula, Stavropoulos, Athanasios, Antonoglou, Anastasia, Nikolaou, Kostas C., Samiotaki, Martina, Szantai, Eszter, Saviolaki, Dimitra, Brown, Peter J., Sideras, Paschalis, Panayotou, George, Talianidis, Iannis

“…TGF-β signaling regulates a variety of cellular processes, including proliferation, apoptosis, differentiation, immune responses, and fibrogenesis. Here, we…”
Get full text

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors by Dahlin, Jayme L., Nelson, Kathryn M., Strasser, Jessica M., Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena M., Organ, Shawna, Cuellar, Matthew, Singh, Gurpreet, Shrimp, Jonathan H., Nguyen, Nghi, Meier, Jordan L., Arrowsmith, Cheryl H., Brown, Peter J., Baell, Jonathan B., Walters, Michael A.

“…Many compounds with potentially reactive chemical motifs and poor physicochemical properties are published as selective modulators of biomolecules without…”
Get full text

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1 by Konze, Kyle D, Ma, Anqi, Li, Fengling, Barsyte-Lovejoy, Dalia, Parton, Trevor, MacNevin, Christopher J, Liu, Feng, Gao, Cen, Huang, Xi-Ping, Kuznetsova, Ekaterina, Rougie, Marie, Jiang, Alice, Pattenden, Samantha G, Norris, Jacqueline L, James, Lindsey I, Roth, Bryan L, Brown, Peter J, Frye, Stephen V, Arrowsmith, Cheryl H, Hahn, Klaus M, Wang, Gang Greg, Vedadi, Masoud, Jin, Jian

“…EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27 (H3K27). The trimethylation of…”
Get full text

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling by Scheer, Sebastian, Ackloo, Suzanne, Medina, Tiago S., Schapira, Matthieu, Li, Fengling, Ward, Jennifer A., Lewis, Andrew M., Northrop, Jeffrey P., Richardson, Paul L., Kaniskan, H. Ümit, Shen, Yudao, Liu, Jing, Smil, David, McLeod, David, Zepeda-Velazquez, Carlos A., Luo, Minkui, Jin, Jian, Barsyte-Lovejoy, Dalia, Huber, Kilian V. M., De Carvalho, Daniel D., Vedadi, Masoud, Zaph, Colby, Brown, Peter J., Arrowsmith, Cheryl H.

“…Protein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical…”
Get full text

From Discovery to the First Month of the Type II Supernova 2023ixf: High and Variable Mass Loss in the Final Year before Explosion by Hiramatsu, Daichi, Tsuna, Daichi, Berger, Edo, Itagaki, Koichi, Goldberg, Jared A., Gomez, Sebastian, Kishalay De, Hosseinzadeh, Griffin, Bostroem, K. Azalee, Brown, Peter J., Arcavi, Iair, Bieryla, Allyson, Blanchard, Peter K., Esquerdo, Gilbert A., Farah, Joseph, Howell, D. Andrew, Matsumoto, Tatsuya, McCully, Curtis, Newsome, Megan, Gonzalez, Estefania Padilla, Pellegrino, Craig, Rhee, Jaehyon, Terreran, Giacomo, Vinkó, József, Wheeler, J. Craig

“…Abstract We present the discovery of the Type II supernova SN 2023ixf in M101 and follow-up photometric and spectroscopic observations, respectively, in the…”
Get full text

Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations by Wu, Hong, Zeng, Hong, Dong, Aiping, Li, Fengling, He, Hao, Senisterra, Guillermo, Seitova, Alma, Duan, Shili, Brown, Peter J, Vedadi, Masoud, Arrowsmith, Cheryl H, Schapira, Matthieu

“…Polycomb repressive complex 2 (PRC2) is an important regulator of cellular differentiation and cell type identity. Overexpression or activating mutations of…”
Get full text

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase by Xiong, Yan, Li, Fengling, Babault, Nicolas, Dong, Aiping, Zeng, Hong, Wu, Hong, Chen, Xin, Arrowsmith, Cheryl H, Brown, Peter J, Liu, Jing, Vedadi, Masoud, Jin, Jian

“…G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% sequence identity in their catalytic…”
Get full text

Significant luminosity differences of two twin Type Ia supernovae by Foley, Ryan J, Hoffmann, Samantha L, Macri, Lucas M, Riess, Adam G, Brown, Peter J, Filippenko, Alexei V, Graham, Melissa L, Milne, Peter A

“…ABSTRACT The Type Ia supernovae (SNe Ia) 2011by, hosted in NGC 3972, and 2011fe, hosted in M101, are optical ‘twins,’ having almost identical optical…”
Get full text

MULTI-WAVELENGTH OBSERVATIONS OF THE ENDURING TYPE IIn SUPERNOVAE 2005ip AND 2006jd by STRITZINGER, Maximilian, TADDIA, Francesco, CAMPILLAY, Abdo, CASTELLON, Sergio, CONTRERAS, Carlos, FOLATELLI, Gastón, HABERGHAM, S. M, HAMUY, Mario, HJORTH, Jens, JAMES, Phil A, KRZEMINSKI, Wojtek, MATTILA, Seppo, FRANSSON, Claes, PERSSON, Sven E, ROTH, Miguel, FOX, Ori D, MORRELL, Nidia, PHILLIPS, M. M, SOLLERMAN, Jesper, ANDERSON, J. P, BOLDT, Luis, BROWN, Peter J

“…We present an observational study of the Type IIn supernovae (SNe IIn) 2005ip and 2006jd. Broadband UV, optical, and near-IR photometry, and visual-wavelength…”
Get full text