Search Results - "Brown, Patricia M. G. E."

Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X‑ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)‑4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid by Krogsgaard-Larsen, Niels, Delgar, Claudia G, Koch, Karina, Brown, Patricia M. G. E, Møller, Charlotte, Han, Liwei, Huynh, Tri H. V, Hansen, Stinne W, Nielsen, Birgitte, Bowie, Derek, Pickering, Darryl S, Kastrup, Jette Sandholm, Frydenvang, Karla, Bunch, Lennart

“…Ionotropic glutamate receptor antagonists are valuable tool compounds for studies of neurological pathways in the central nervous system. On the basis of…”
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Single-particle cryo-EM at atomic resolution by Nakane, Takanori, Kotecha, Abhay, Sente, Andrija, McMullan, Greg, Masiulis, Simonas, Brown, Patricia M. G. E., Grigoras, Ioana T., Malinauskaite, Lina, Malinauskas, Tomas, Miehling, Jonas, Uchański, Tomasz, Yu, Lingbo, Karia, Dimple, Pechnikova, Evgeniya V., de Jong, Erwin, Keizer, Jeroen, Bischoff, Maarten, McCormack, Jamie, Tiemeijer, Peter, Hardwick, Steven W., Chirgadze, Dimitri Y., Murshudov, Garib, Aricescu, A. Radu, Scheres, Sjors H. W.

“…The three-dimensional positions of atoms in protein molecules define their structure and their roles in biological processes. The more precisely atomic…”
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Binding Mode of an α‑Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1 by Demmer, Charles S, Møller, Charlotte, Brown, Patricia M. G. E, Han, Liwei, Pickering, Darryl S, Nielsen, Birgitte, Bowie, Derek, Frydenvang, Karla, Kastrup, Jette S, Bunch, Lennart

“…Two α-amino acid-functionalized quinoxalines, 1a (CNG-10301) and 1b (CNG-10300), of a quinoxaline moiety coupled to an amino acid moiety were designed,…”
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Alternative Splicing of the Flip/Flop Cassette and TARP Auxiliary Subunits Engage in a Privileged Relationship That Fine-Tunes AMPA Receptor Gating by Perozzo, Amanda M, Brown, Patricia M G E, Bowie, Derek

“…Alternative splicing of AMPA-type glutamate receptors (AMPARs) and allosteric modulation by auxiliary subunits, such as transmembrane AMPAR regulatory proteins…”
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Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation by Brown, Patricia M G E, McGuire, Hugo, Bowie, Derek

“…Most ligand- and voltage-gated ion channels assemble as signaling complexes consisting of pore-forming and auxiliary subunits. In the mammalian brain,…”
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Functional Validation of Heteromeric Kainate Receptor Models by Paramo, Teresa, Brown, Patricia M.G.E., Musgaard, Maria, Bowie, Derek, Biggin, Philip C.

“…Kainate receptors require the presence of external ions for gating. Most work thus far has been performed on homomeric GluK2 but, in vivo, kainate receptors…”
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Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission by Accardi, Michael V., Daniels, Bryan A., Brown, Patricia M.G.E., Fritschy, Jean-Marc, Tyagarajan, Shiva K., Bowie, Derek

“…Neuronal communication imposes a heavy metabolic burden in maintaining ionic gradients essential for action potential firing and synaptic signalling. Although…”
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Kainate receptor pore‐forming and auxiliary subunits regulate channel block by a novel mechanism by Brown, Patricia M. G. E., Aurousseau, Mark R. P., Musgaard, Maria, Biggin, Philip C., Bowie, Derek

“…Key points Kainate receptor heteromerization and auxiliary subunits, Neto1 and Neto2, attenuate polyamine ion‐channel block by facilitating blocker permeation…”
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α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells by Accardi, Michael V, Brown, Patricia M G E, Miraucourt, Loïs S, Orser, Beverley A, Bowie, Derek

“…Activity-dependent strengthening of central synapses is a key factor driving neuronal circuit behavior in the vertebrate CNS. At fast inhibitory synapses,…”
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Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor by Khanra, Nandish, Brown, Patricia Mge, Perozzo, Amanda M, Bowie, Derek, Meyerson, Joel R

“…Kainate receptors (KARs) are L-glutamate-gated ion channels that regulate synaptic transmission and modulate neuronal circuits. KARs have strict assembly rules…”
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Hydrogen peroxide increases GABAA receptor-mediated tonic current in hippocampal neurons by Penna, Antonello, Wang, Dian-Shi, Yu, Jieying, Lecker, Irene, Brown, Patricia M G E, Bowie, Derek, Orser, Beverley A

“…Hydrogen peroxide (H2O2), a key reactive oxygen species, is produced at low levels during normal cellular metabolism and at higher concentrations under…”
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Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission by Accardi, Michael V., Daniels, Bryan A., Brown, Patricia M.G.E., Fritschy, Jean-Marc, Tyagarajan, Shiva K., Bowie, Derek

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Functional Characterization of AMPA and Kainate Receptor Gating Properties by Brown, Patricia M. G. E

“…Ionotropic glutamate receptors (iGluRs) mediate the majority of fast excitatory neurotransmission in the mammalian central nervous system (CNS). While…”
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