Search Results - "Brown, Nicola J."

Angiosarcoma by Young, Robin J, Dr, Brown, Nicola J, Prof, Reed, Malcolm W, Prof, Hughes, David, FRCPath, Woll, Penella J, Prof

“…Summary Angiosarcomas are rare soft-tissue sarcomas of endothelial cell origin that have a poor prognosis. They can arise anywhere in the body, most commonly…”
Get full text

A critical analysis of current in vitro and in vivo angiogenesis assays by Staton, Carolyn A., Reed, Malcolm W. R., Brown, Nicola J.

“…Summary The study of angiogenesis has grown exponentially over the past 40 years with the recognition that angiogenesis is essential for numerous pathologies…”
Get full text

Cep63 and cep152 cooperate to ensure centriole duplication by Brown, Nicola J, Marjanović, Marko, Lüders, Jens, Stracker, Travis H, Costanzo, Vincenzo

“…Centrosomes consist of two centrioles embedded in pericentriolar material and function as the main microtubule organising centres in dividing animal cells…”
Get full text

Changes in dynamics of tumor/endothelial cell adhesive interactions depending on endothelial cell growth state and elastic properties by Xie, Leike, Sun, Zhe, Brown, Nicola J, Glinskii, Olga V, Meininger, Gerald A, Glinsky, Vladislav V

“…Cancer cell adhesion to the endothelium is a crucial process in hematogenous metastasis, but how the integrity of the endothelial barrier and endothelial cell…”
Get full text

Lactate dehydrogenase-B is silenced by promoter methylation in a high frequency of human breast cancers by Brown, Nicola J, Higham, Sue E, Perunovic, Branko, Arafa, Mohammad, Balasubramanian, Sabapathy, Rehman, Ishtiaq

“…Under normoxia, non-malignant cells rely on oxidative phosphorylation for their ATP production, whereas cancer cells rely on Glycolysis; a phenomenon known as…”
Get full text

The bone metastasis niche in breast cancer: potential overlap with the haematopoietic stem cell niche in vivo by Allocca, Gloria, Hughes, Russell, Wang, Ning, Brown, Hannah K, Ottewell, Penelope D, Brown, Nicola J, Holen, Ingunn

“…Background: Bone metastasis is one of the most common complications of advanced breast cancer. During dissemination to bone, breast cancer cells locate in a…”
Get full text

Vascular smooth muscle cell stiffness and adhesion to collagen I modified by vasoactive agonists by Hong, Zhongkui, Reeves, Kimberley J, Sun, Zhe, Li, Zhaohui, Brown, Nicola J, Meininger, Gerald A

“…In vascular smooth muscle cells (VSMCs) integrin-mediated adhesion to extracellular matrix (ECM) proteins play important roles in sustaining vascular tone and…”
Get full text

Temporal and molecular dynamics of human metastatic breast carcinoma cell adhesive interactions with human bone marrow endothelium analyzed by single-cell force spectroscopy by Xie, Leike, Sun, Zhe, Hong, Zhongkui, Brown, Nicola J, Glinskii, Olga V, Rittenhouse-Olson, Kate, Meininger, Gerald A, Glinsky, Vladislav V

“…Bone is a common site of metastasis for breast cancer and the mechanisms of metastasis are not fully elucidated. The purpose of our study was to characterize…”
Get full text

Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis by Alfieri, Alessio, Watson, Jay J, Kammerer, Richard A, Tasab, Mohammed, Progias, Pavlos, Reeves, Kimberly, Brown, Nicola J, Brookes, Zoe L

“…Severe sepsis is characterised by intravascular or extravascular infection with microbial agents, systemic inflammation and microcirculatory dysfunction,…”
Get full text

The breast tumor microenvironment: role in cancer development, progression and response to therapy by Mittal, Suruchi, Brown, Nicola J, Holen, Ingunn

“…Numerous clinical and pre-clinical studies have provided ample evidence supporting that the tumor microenvironment plays a significant role during breast…”
Get more information

Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer by Brown, Hannah K, Allocca, Gloria, Ottewell, Penelope D, Wang, Ning, Brown, Nicola J, Croucher, Peter I, Eaton, Colby L, Holen, Ingunn

“…Breast cancer cells colonize the skeleton by homing to specific niches, but the involvement of osteoblasts in tumour cell seeding, colonization, and…”
Get full text

Quantum dot-conjugated anti-GRP78 scFv inhibits cancer growth in mice by Xu, Weiming, Liu, Lizhi, Brown, Nicola J, Christian, Sven, Hornby, David

“…Semiconductor quantum dots (Qdots) have recently been shown to offer significant advantages over conventional fluorescent probes to image and study biological…”
Get full text

Neuropilin-1 and neuropilin-2 expression in the adenoma-carcinoma sequence of colorectal cancer by Staton, Carolyn A, Koay, Ivan, Wu, Jessie M, Hoh, Leslie, Reed, Malcolm W R, Brown, Nicola J

“…Aims Neuropilin‐1 (NRP1) and neuropilin‐2 (NRP2) are transmembrane glycoproteins which interact with vascular endothelial growth factor (VEGF) to prevent…”
Get full text

The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia by Cole-Healy, Zachary, Vergani, Patricia, Hunter, Keith, Brown, Nicola J., Reed, Malcolm W.R., Staton, Carolyn A.

“…This study aimed to identify the expression of semaphorin 3C (SEMA3C) in the normal-metastatic spectrum of breast and oral cancers, and correlate expression…”
Get full text

MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells by Brito, Jose L.R, Walker, Brian, Jenner, Matthew, Dickens, Nicholas J, Brown, Nicola J.M, Ross, Fiona M, Avramidou, Athanasia, Irving, Julie A.E, Gonzalez, David, Davies, Faith E, Morgan, Gareth J

“…1 Institute for Cancer Research, Section of Haemato-Oncology, London 2 Department of Medical and Molecular Genetics, Division of Genetics and Molecular…”
Get full text

Near infrared fluorescence imaging of rabbit thyroid and parathyroid glands by Antakia, Ramez, MBChB, MRCS, Gayet, Pascal, PhD, Guillermet, Stephanie, PhD, Stephenson, Tim J., MBChB, MD, MBA, FRCPath, Brown, Nicola J., BSc, DipEd, PhD, Harrison, Barney J., FRCS, MS, Balasubramanian, Saba P., FRCS, PhD

“…Abstract Background Near infrared fluorescence imaging using intravenous methylene blue (MB) is a novel technique that has potential to aid the parathyroid…”
Get full text

On the mechanism of loading the PCNA sliding clamp by RFC by Dionne, Isabelle, Brown, Nicola J, Woodgate, Roger, Bell, Stephen D

“…Sliding clamps play central roles in a broad range of DNA replication and repair processes. The clamps form circular molecules that must be opened and resealed…”
Get full text

Breast cancer cells stimulate osteoprotegerin (OPG) production by endothelial cells through direct cell contact by Reid, Penny E, Brown, Nicola J, Holen, Ingunn

“…Angiogenesis, the sprouting of capillaries from existing blood vessels, is central to tumour growth and progression, however the molecular regulation of this…”
Get full text

ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase by McGown, Caroline C., Brown, Nicola J., Hellewell, Paul G., Brookes, Zoë L.S.

“…Sepsis may be modeled using lipopolysaccharide (LPS), which alters levels of nitric oxide (NO), synthesized via endothelial and inducible nitric oxide synthase…”
Get full text

The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo by Brookes, Zoë L S, Stedman, Emily N, Brown, Nicola J, Hebbes, Christopher P, Guerrini, Remo, Calo, Girolamo, Reilly, Charles S, Lambert, David G

“…Microvascular inflammation occurs during sepsis and the endogenous opioid-like peptide nociceptin/orphanin FQ (N/OFQ) is known to regulate inflammation. This…”
Get full text