Search Results - "Brown, Nicola"

The breast tumor microenvironment: role in cancer development, progression and response to therapy by Mittal, Suruchi, Brown, Nicola J, Holen, Ingunn

“…Numerous clinical and pre-clinical studies have provided ample evidence supporting that the tumor microenvironment plays a significant role during breast…”
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Balancing opportunity and exploitation: unpaid internships in sports nutrition by Brown, Nicola

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Beyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines by Stephens, Alexander J, Burgess-Brown, Nicola A, Jiang, Shisong

“…Peptide-based cancer vaccines rely upon the strong activation of the adaptive immune response to elicit its effector function. They have shown to be highly…”
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The Prevalence and Impact of Heavy Menstrual Bleeding (Menorrhagia) in Elite and Non-Elite Athletes by Bruinvels, Georgie, Burden, Richard, Brown, Nicola, Richards, Toby, Pedlar, Charles

“…To identify the prevalence and impact of heavy menstrual bleeding (HMB) in exercising females where anemia may have a significant effect on training and…”
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Angiosarcoma by Young, Robin J, Dr, Brown, Nicola J, Prof, Reed, Malcolm W, Prof, Hughes, David, FRCPath, Woll, Penella J, Prof

“…Summary Angiosarcomas are rare soft-tissue sarcomas of endothelial cell origin that have a poor prognosis. They can arise anywhere in the body, most commonly…”
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Cep63 and cep152 cooperate to ensure centriole duplication by Brown, Nicola J, Marjanović, Marko, Lüders, Jens, Stracker, Travis H, Costanzo, Vincenzo

“…Centrosomes consist of two centrioles embedded in pericentriolar material and function as the main microtubule organising centres in dividing animal cells…”
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Mechanical Heterogeneity in the Bone Microenvironment as Characterized by Atomic Force Microscopy by Chen, Xinyue, Hughes, Russell, Mullin, Nic, Hawkins, Rhoda J., Holen, Ingunn, Brown, Nicola J., Hobbs, Jamie K.

“…Bones are structurally heterogeneous organs with diverse functions that undergo mechanical stimuli across multiple length scales. Mechanical characterization…”
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Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2) by Grieben, Mariana, Pike, Ashley C W, Shintre, Chitra A, Venturi, Elisa, El-Ajouz, Sam, Tessitore, Annamaria, Shrestha, Leela, Mukhopadhyay, Shubhashish, Mahajan, Pravin, Chalk, Rod, Burgess-Brown, Nicola A, Sitsapesan, Rebecca, Huiskonen, Juha T, Carpenter, Elisabeth P

“…The cryo-EM structure of human polycystin-2 (PC2) in a closed conformation reveals a domain located above the pore filter, forming an upper vestibule and…”
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Use of methylene blue and near-infrared fluorescence in thyroid and parathyroid surgery by Hillary, Sarah L., Guillermet, Stephanie, Brown, Nicola J., Balasubramanian, Sabapathy P.

“…Purpose Intraoperative localisation and preservation of parathyroid glands improves outcomes following thyroid and parathyroid surgery. This can be facilitated…”
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Phospho‐regulation, nucleotide binding and ion access control in potassium‐chloride cotransporters by Chi, Gamma, Ebenhoch, Rebecca, Man, Henry, Tang, Haiping, Tremblay, Laurence E, Reggiano, Gabriella, Qiu, Xingyu, Bohstedt, Tina, Liko, Idlir, Almeida, Fernando G, Garneau, Alexandre P, Wang, Dong, McKinley, Gavin, Moreau, Christophe P, Bountra, Kiran D, Abrusci, Patrizia, Mukhopadhyay, Shubhashish M M, Fernandez‐Cid, Alejandra, Slimani, Samira, Lavoie, Julie L, Burgess‐Brown, Nicola A, Tehan, Ben, DiMaio, Frank, Jazayeri, Ali, Isenring, Paul, Robinson, Carol V, Dürr, Katharina L

“…Potassium‐coupled chloride transporters (KCCs) play crucial roles in regulating cell volume and intracellular chloride concentration. They are…”
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Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome by Barr, Alastair J., Ugochukwu, Emilie, Lee, Wen Hwa, King, Oliver N.F., Filippakopoulos, Panagis, Alfano, Ivan, Savitsky, Pavel, Burgess-Brown, Nicola A., Müller, Susanne, Knapp, Stefan

“…Protein tyrosine phosphatases (PTPs) play a critical role in regulating cellular functions by selectively dephosphorylating their substrates. Here we present…”
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Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO‑N and 6‑HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles by Scalacci, Nicoló, Black, Gary W, Mattedi, Giulio, Brown, Nicola L, Turner, Nicholas J, Castagnolo, Daniele

“…A chemoenzymatic cascade process for the sustainable production of pyrroles has been developed. Pyrroles were synthesized by exploiting the previously…”
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Biocatalytic and Chemo-Enzymatic Synthesis of Quinolines and 2‑Quinolones by Monoamine Oxidase (MAO-N) and Horseradish Peroxidase (HRP) Biocatalysts by Xiang, Haoyue, Ferla, Salvatore, Varricchio, Carmine, Brancale, Andrea, Brown, Nicola L., Black, Gary W., Turner, Nicholas J., Castagnolo, Daniele

“…The oxidative aromatization of aliphatic N-heterocycles is a fundamental organic transformation for the preparation of a diverse array of heteroaromatic…”
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A critical analysis of current in vitro and in vivo angiogenesis assays by Staton, Carolyn A., Reed, Malcolm W. R., Brown, Nicola J.

“…Summary The study of angiogenesis has grown exponentially over the past 40 years with the recognition that angiogenesis is essential for numerous pathologies…”
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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac by Dong, Yin Yao, Pike, Ashley C. W., Mackenzie, Alexandra, McClenaghan, Conor, Aryal, Prafulla, Dong, Liang, Quigley, Andrew, Grieben, Mariana, Goubin, Solenne, Mukhopadhyay, Shubhashish, Ruda, Gian Filippo, Clausen, Michael V., Cao, Lishuang, Brennan, Paul E., Burgess-Brown, Nicola A., Sansom, Mark S. P., Tucker, Stephen J., Carpenter, Elisabeth P.

“…TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs…”
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The structural basis of fatty acid elongation by the ELOVL elongases by Nie, Laiyin, Pascoa, Tomas C., Pike, Ashley C. W., Bushell, Simon R., Quigley, Andrew, Ruda, Gian Filippo, Chu, Amy, Cole, Victoria, Speedman, David, Moreira, Tiago, Shrestha, Leela, Mukhopadhyay, Shubhashish M. M., Burgess-Brown, Nicola A., Love, James D., Brennan, Paul E., Carpenter, Elisabeth P.

“…Very long chain fatty acids (VLCFAs) are essential building blocks for the synthesis of ceramides and sphingolipids. The first step in the fatty acid…”
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Lactate dehydrogenase-B is silenced by promoter methylation in a high frequency of human breast cancers by Brown, Nicola J, Higham, Sue E, Perunovic, Branko, Arafa, Mohammad, Balasubramanian, Sabapathy, Rehman, Ishtiaq

“…Under normoxia, non-malignant cells rely on oxidative phosphorylation for their ATP production, whereas cancer cells rely on Glycolysis; a phenomenon known as…”
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High-throughput production of human proteins for crystallization: The SGC experience by Savitsky, Pavel, Bray, James, Cooper, Christopher D.O., Marsden, Brian D., Mahajan, Pravin, Burgess-Brown, Nicola A., Gileadi, Opher

“…Producing purified human proteins with high yield and purity remains a considerable challenge. We describe the methods utilized in the Structural Genomics…”
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Vascular smooth muscle cell stiffness and adhesion to collagen I modified by vasoactive agonists by Hong, Zhongkui, Reeves, Kimberley J, Sun, Zhe, Li, Zhaohui, Brown, Nicola J, Meininger, Gerald A

“…In vascular smooth muscle cells (VSMCs) integrin-mediated adhesion to extracellular matrix (ECM) proteins play important roles in sustaining vascular tone and…”
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The prevalence, severity, and impact of breast pain in the general population by Scurr, Joanna, Hedger, Wendy, Morris, Paul, Brown, Nicola

“…Breast pain has been investigated in clinical populations; however we have yet to understand the prevalence and severity of this condition in the general…”
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