Search Results - "Brown, Nicholas E."

Development of an Energy Efficient and Cost Effective Autonomous Vehicle Research Platform by Brown, Nicholas E., Rojas, Johan F., Goberville, Nicholas A., Alzubi, Hamzeh, AlRousan, Qusay, Wang, Chieh (Ross), Huff, Shean, Rios-Torres, Jackeline, Ekti, Ali Riza, LaClair, Tim J., Meyer, Richard, Asher, Zachary D.

“…Commercialization of autonomous vehicle technology is a major goal of the automotive industry, thus research in this space is rapidly expanding across the…”
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Tumor Cell Autonomous RON Receptor Expression Promotes Prostate Cancer Growth Under Conditions of Androgen Deprivation by Brown, Nicholas E., Paluch, Andrew M., Nashu, Madison A., Komurov, Kakajan, Waltz, Susan E.

“…Current treatment strategies provide minimal results for patients with castration-resistant prostate cancer (CRPC). Attempts to target the androgen receptor…”
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Prostate tumor RON receptor signaling mediates macrophage recruitment to drive androgen deprivation therapy resistance through Gas6‐mediated Axl and RON signaling by Brown, Nicholas E., Jones, Angelle, Hunt, Brian G., Waltz, Susan E.

“…Background Androgen deprivation therapy (ADT), or chemical castration, is the first‐line therapy for prostate cancer; however, resistance leaves few treatment…”
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Prostate Epithelial RON Signaling Promotes M2 Macrophage Activation to Drive Prostate Tumor Growth and Progression by Sullivan, Camille, Brown, Nicholas E, Vasiliauskas, Juozas, Pathrose, Peterson, Starnes, Sandra L, Waltz, Susan E

“…Effective treatment of advanced prostate cancer persists as a significant clinical need as only 30% of patients with distant disease survive to 5 years after…”
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Preclinical characterization of pirtobrutinib, a highly selective, noncovalent (reversible) BTK inhibitor by Gomez, Eliana B., Ebata, Kevin, Randeria, Hetal S., Rosendahl, Mary S., Cedervall, E. Peder, Morales, Tony H., Hanson, Lauren M., Brown, Nicholas E., Gong, Xueqian, Stephens, Jennifer, Wu, Wenjuan, Lippincott, Isabel, Ku, Karin S., Walgren, Richard A., Abada, Paolo B., Ballard, Joshua A., Allerston, Charles K., Brandhuber, Barbara J.

“…•Pirtobrutinib is a potent, noncovalent (reversible), highly selective inhibitor of BTK and C481-mutant BTK.•Pirtobrutinib is efficacious in B-cell models…”
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Loss of Ron receptor signaling leads to reduced obesity, diabetic phenotypes and hepatic steatosis in response to high-fat diet in mice by Stuart, William D, Brown, Nicholas E, Paluch, Andrew M, Waltz, Susan E

“…The Ron receptor tyrosine kinase is a heterodimeric, membrane-spanning glycoprotein that participates in divergent processes, including proliferation,…”
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Evaluation of Autonomous Vehicle Sensing and Compute Load on a Chassis Dynamometer by Brown, Nicholas E., Motallebiaraghi, Farhang, Rojas, Johan Fanas, Ayantayo, Sherif, Meyer, Richard, Asher, Zachary D, Ekti, Ali Riza, Wang, Chieh Ross, Goberville, Nicholas A., Feinberg, Ben

“…The sensing and compute load auxiliary energy consumption in autonomous vehicles may be significant due to the large number of sensors and the high compute…”
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Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment by Brown, Nicholas F, Marshall, John F

“…TGFβ (transforming growth factor-beta) is a pleotropic cytokine with contrasting effects in cancer. In normal tissue and early tumours, TGFβ acts as a tumour…”
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Chawin and Chavín: evidence of interregional interaction involving the Peruvian central highlands during the late Initial Period by Brown, Nicholas E.

“…This article introduces the archaeological site of Chawin Punta, located in the Chaupihuaranga Basin of Pasco, Peru. Surface investigations there have…”
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AV Operation and Energy Efficiency Improved Through the Evaluation and Demonstration of AV Sensor Technology by Brown, Nicholas E

“…The majority of states have passed legislation or have signed an executive order enacting safe testing, development, and deployment of level 4 and level 5…”
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Pirtobrutinib preclinical characterization: a highly selective, non-covalent (reversible) BTK inhibitor by Gomez, Eliana B, Ebata, Kevin, Randeria, Hetal S, Rosendahl, Mary S, Cedervall, Ernst Peder, Morales, Tony H, Hanson, Lauren M, Brown, Nicholas E, Gong, Xueqian, Stephens, Jennifer Rachelle, Wu, Wenjuan, Lippincott, Isabel, Ku, Karin S., Walgren, Richard A, Abada, Paolo B, Ballard, Joshua A, Allerston, Charles K, Brandhuber, Barbara J

“…Bruton tyrosine kinase (BTK), a nonreceptor tyrosine kinase, is a major therapeutic target for B-cell driven malignancies. However, approved covalent BTK…”
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Tumor Cell Autonomous RON Receptor Expression Promotes Prostate Cancer Growth Under Conditions of Androgen Deprivation12 by Brown, Nicholas E., Paluch, Andrew M., Nashu, Madison A., Komurov, Kakajan, Waltz, Susan E.

“…Current treatment strategies provide minimal results for patients with castration-resistant prostate cancer (CRPC). Attempts to target the androgen receptor…”
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Ancient Andean Archipelagos: Human Interaction and Social Innovation at Chawin Punta and Kunturay in the East-Central Highlands of Pasco, Peru by Brown, Nicholas E

“…This dissertation studies the dynamic relationship between interaction and innovation in ancient Peru, where archipelagos of social movement developed among…”
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Novel Roles for Ron Receptor Signaling as a Driver of Therapeutic Resistance in Prostate Cancer by Brown, Nicholas E

“…Approximately 14% of all men will be diagnosed with prostate cancer. Not only is prostate cancer very prevalent, but as the second leading cause of cancer…”
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Computer simulations and reality in clarinet tones by Brown, Nicholas E., Schumacher, Robert T.

“…One goal of computer simulations of musical instrument oscillations is to produce oscillations that actually sound like the acoustic instrument being modeled…”
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