Search Results - "Brown, Nelson E"

Palbociclib-induced autophagy and senescence in gastric cancer cells by Valenzuela, Claudio A., Vargas, Leandro, Martinez, Valentina, Bravo, Sindy, Brown, Nelson E.

“…Targeting cyclin D-CDK4/6 kinase complexes has recently been shown to increase the survival of breast cancer patients with estrogen receptor positive breast…”
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Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy by Cayo, Angel, Venturini, Whitney, Rebolledo-Mira, Danitza, Moore-Carrasco, Rodrigo, Herrada, Andrés A, Nova-Lamperti, Estefanía, Valenzuela, Claudio, Brown, Nelson E

“…Despite not dividing, senescent cells acquire the ability to synthesize and secrete a plethora of bioactive molecules, a feature known as the…”
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Platelet Activation Is Triggered by Factors Secreted by Senescent Endothelial HMEC-1 Cells In Vitro by Venturini, Whitney, Olate-Briones, Alexandra, Valenzuela, Claudio, Méndez, Diego, Fuentes, Eduardo, Cayo, Angel, Mancilla, Daniel, Segovia, Raul, Brown, Nelson E, Moore-Carrasco, Rodrigo

“…Aging is one of the main risk factors for the development of chronic diseases, with both the vascular endothelium and platelets becoming functionally altered…”
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SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells by Valenzuela, Claudio A, Quintanilla, Ricardo, Olate-Briones, Alexandra, Venturini, Whitney, Mancilla, Daniel, Cayo, Angel, Moore-Carrasco, Rodrigo, Brown, Nelson E

“…Alterations in platelet aggregation are common in aging individuals and in the context of age-related pathologies such as cancer. So far, however, the effects…”
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Cyclin D1 activity regulates autophagy and senescence in the mammary epithelium by Brown, Nelson E, Jeselsohn, Rinath, Bihani, Teeru, Hu, Miaofen G, Foltopoulou, Parthena, Kuperwasser, Charlotte, Hinds, Philip W

“…Overexpression of cyclin D1 is believed to endow mammary epithelial cells (MEC) with a proliferative advantage by virtue of its contribution to pRB…”
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The Potential Role of Senescence As a Modulator of Platelets and Tumorigenesis by Valenzuela, Claudio A, Quintanilla, Ricardo, Moore-Carrasco, Rodrigo, Brown, Nelson E

“…In addition to thrombus formation, alterations in platelet function are frequently observed in cancer patients. Importantly, both thrombus and tumor formation…”
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Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1⁻/⁻ mice by Gutierrez, Gabriel M, Kong, Elizabeth, Sabbagh, Yves, Brown, Nelson E, Lee, Jong-Seo, Demay, Marie B, Thomas, David M, Hinds, Philip W

“…We have previously shown that the retinoblastoma protein (pRb) can activate expression of Runx2-dependent, bone-specific genes in cultured cells. We now show…”
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Cyclin D1 Kinase Activity Is Required for the Self-Renewal of Mammary Stem and Progenitor Cells that Are Targets of MMTV-ErbB2 Tumorigenesis by Jeselsohn, Rinath, Brown, Nelson E., Arendt, Lisa, Klebba, Ina, Hu, Miaofen G., Kuperwasser, Charlotte, Hinds, Philip W.

“…Transplantation studies have demonstrated the existence of mammary progenitor cells with the ability to self-renew and regenerate a functional mammary gland…”
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The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development by LANDIS, Mark W, BROWN, Nelson E, BAKER, Gregory L, SHIFRIN, Anna, DAS, Manjusri, YAN GENG, SICINSKI, Piotr, HINDS, Philip W

“…Cyclin D1 is a multifunctional, tumor-associated protein that interacts with pRb via a conserved LxCxE motif, activates a kinase partner, directs the…”
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Abstract 2838: The role of cyclin D1-associated kinase activity in the regulation of autophagy and senescence in gastric cancer cells by Vargas, Leandro, Bravo, Sindy, Valenzuela, Claudio, Brown, Nelson E.

“…Abstract Introduction: Cyclin D1 regulates cell cycle progression through its ability to bind and activate cyclin-dependent kinases 4 and 6 (CDK4/6). Recent…”
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Abstract 1261: Detection of autophagy in gastric mucosae of Chilean individuals residing in a geographic region characterized by high rates of gastric cancer-related death by Corvalan, Alejandro, Pulgar, Hernan, Cruzat, Claudio, Cespedes, Nicole, Ruiz, Francisco, Prado, Rodrigo, Brown, Nelson E.

“…Abstract Gastric cancer is the fourth most common cancer worldwide. In Chile, gastric cancer is the first cause of cancer-related deaths, affecting most…”
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Abstract B26: Lack of cyclin D1 kinase activity leads to reduced levels of ErbB2-induced senescence and activation of the Wnt signaling pathway in the mammary gland by Brown, Nelson E., Kuperwasser, Charlotte, Hinds, Philip W.

“…Abstract Proper orchestration of the Oncogene-induced Senescence (OIS) checkpoint relies upon the activation of the ARF-p53 and/or the p16 INK4a-pRB tumor…”
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Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1^sup -/-^ mice by Gutierrez, Gabriel M, Kong, Elizabeth, Sabbagh, Yves, Brown, Nelson E, Lee, Jong-Seo, Demay, Marie B, Thomas, David M, Hinds, Philip W

“…We have previously shown that the retinoblastoma protein (pRb) can activate expression of Runx2-dependent, bone-specific genes in cultured cells. We now show…”
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Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1 super(-/-) mice by Gutierrez, Gabriel M, Kong, Elizabeth, Sabbagh, Yves, Brown, Nelson E, Lee, Jong-Seo, Demay, Marie B, Thomas, David M, Hinds, Philip W

“…We have previously shown that the retinoblastoma protein (pRb) can activate expression of Runx2- dependent, bone-specific genes in cultured cells. We now show…”
Get full text

Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1⁻/⁻ mice by Gutierrez, Gabriel M, Kong, Elizabeth, Sabbagh, Yves, Brown, Nelson E, Lee, Jong-Seo, Demay, Marie B, Thomas, David M, Hinds, Philip W

“…We have previously shown that the retinoblastoma protein (pRb) can activate expression of Runx2-dependent, bone-specific genes in cultured cells. We now show…”
Get full text