Search Results - "Brown, Milton E."

MCUb Induction Protects the Heart From Postischemic Remodeling by Huo, Jiuzhou, Lu, Shan, Kwong, Jennifer Q., Bround, Michael J., Grimes, Kelly M., Sargent, Michelle A., Brown, Milton E., Davis, Michael E., Bers, Donald M., Molkentin, Jeffery D.

“…Mitochondrial Ca loading augments oxidative metabolism to match functional demands during times of increased work or injury. However, mitochondrial Ca overload…”
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Cellular encapsulation enhances cardiac repair by Levit, Rebecca D, Landázuri, Natalia, Phelps, Edward A, Brown, Milton E, García, Andres J, Davis, Michael E, Joseph, Giji, Long, Robert, Safley, Susan A, Suever, Jonathan D, Lyle, Alicia N, Weber, Collin J, Taylor, W Robert

“…Stem cells for cardiac repair have shown promise in preclinical trials, but lower than expected retention, viability, and efficacy. Encapsulation is one…”
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Using computational methods to design patient-specific electrospun cardiac patches for pediatric heart failure by Streeter, Benjamin W., Brown, Milton E., Shakya, Preety, Park, Hyun-Ji, Qiu, Jichuan, Xia, Younan, Davis, Michael E.

“…Autologous cardiac cell therapy is a promising treatment for combating the right ventricular heart failure (RVHF) that can occur in patients with congenital…”
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Age‐Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure by Agarwal, Udit, Smith, Amanda W., French, Kristin M., Boopathy, Archana V., George, Alex, Trac, David, Brown, Milton E., Shen, Ming, Jiang, Rong, Fernandez, Janet D., Kogon, Brian E., Kanter, Kirk R., Alsoufi, Baahaldin, Wagner, Mary B., Platt, Manu O., Davis, Michael E.

“…To investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling, the authors injected neonate, infant, or child…”
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The mitochondrial citrate carrier SLC25A1 regulates metabolic reprogramming and morphogenesis in the developing heart by Ohanele, Chiemela, Peoples, Jessica N., Karlstaedt, Anja, Geiger, Joshua T., Gayle, Ashley D., Ghazal, Nasab, Sohani, Fateemaa, Brown, Milton E., Davis, Michael E., Porter, George A., Faundez, Victor, Kwong, Jennifer Q.

“…The developing mammalian heart undergoes an important metabolic shift from glycolysis towards mitochondrial oxidation that is critical to support the…”
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Identification of Therapeutic Covariant MicroRNA Clusters in Hypoxia-Treated Cardiac Progenitor Cell Exosomes Using Systems Biology by Gray, Warren D, French, Kristin M, Ghosh-Choudhary, Shohini, Maxwell, Joshua T, Brown, Milton E, Platt, Manu O, Searles, Charles D, Davis, Michael E

“…RATIONALE:Myocardial infarction is a leading cause of death in developed nations, and there remains a need for cardiac therapeutic systems that mitigate tissue…”
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Over-expression of catalase in myeloid cells confers acute protection following myocardial infarction by Cabigas, E Bernadette, Somasuntharam, Inthirai, Brown, Milton E, Che, Pao Lin, Pendergrass, Karl D, Chiang, Bryce, Taylor, W Robert, Davis, Michael E

“…Cardiovascular disease is the leading cause of death in the United States and new treatment options are greatly needed. Oxidative stress is increased following…”
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Customized Loading of microRNA-126 to Small Extracellular Vesicle-Derived Vehicles Improves Cardiac Function after Myocardial Infarction by Bheri, Sruti, Brown, Milton E., Park, Hyun-Ji, Brazhkina, Olga, Takaesu, Felipe, Davis, Michael E.

“…Small extracellular vesicles (sEVs) are promising for cell-based cardiac repair after myocardial infarction. These sEVs encapsulate potent cargo, including…”
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Experimental, Systems, and Computational Approaches to Understanding the MicroRNA-Mediated Reparative Potential of Cardiac Progenitor Cell–Derived Exosomes From Pediatric Patients by Agarwal, Udit, George, Alex, Bhutani, Srishti, Ghosh-Choudhary, Shohini, Maxwell, Joshua T, Brown, Milton E, Mehta, Yash, Platt, Manu O, Liang, Yaxuan, Sahoo, Susmita, Davis, Michael E

“…RATIONALE:Studies have demonstrated that exosomes can repair cardiac tissue post–myocardial infarction and recapitulate the benefits of cellular therapy…”
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A Bioprinted Cardiac Patch Composed of Cardiac‐Specific Extracellular Matrix and Progenitor Cells for Heart Repair by Bejleri, Donald, Streeter, Benjamin W., Nachlas, Aline L. Y., Brown, Milton E., Gaetani, Roberto, Christman, Karen L., Davis, Michael E.

“…Congenital heart defects are present in 8 of 1000 newborns and palliative surgical therapy has increased survival. Despite improved outcomes, many children…”
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Aggregation of Child Cardiac Progenitor Cells Into Spheres Activates Notch Signaling and Improves Treatment of Right Ventricular Heart Failure by Trac, David, Maxwell, Joshua T, Brown, Milton E, Xu, Chunhui, Davis, Michael E

“…RATIONALE:Congenital heart disease can lead to life-threatening right ventricular (RV) heart failure. Results from clinical trials support expanding cardiac…”
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Encapsulation of Pediatric Cardiac-Derived C-Kit + Cells in Cardiac Extracellular Matrix Hydrogel for Echocardiography-Directed Intramyocardial Injection in Rodents by Shakya, Preety, Brown, Milton E, Davis, Michael E

“…Pediatric cardiac-derived c-kit cell therapies represent an innovative approach for cardiac tissue repair that have demonstrated promising improvements in…”
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High-throughput screening identifies microRNAs that target Nox2 and improve function after acute myocardial infarction by Yang, Junyu, Brown, Milton E, Zhang, Hanshuo, Martinez, Mario, Zhao, Zhihua, Bhutani, Srishti, Yin, Shenyi, Trac, David, Xi, Jianzhong Jeff, Davis, Michael E

“…Myocardial infarction (MI) is the most common cause of heart failure. Excessive production of ROS plays a key role in the pathogenesis of cardiac remodeling…”
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Knockdown of TNF-α by DNAzyme gold nanoparticles as an anti-inflammatory therapy for myocardial infarction by Somasuntharam, Inthirai, Yehl, Kevin, Carroll, Sheridan L, Maxwell, Joshua T, Martinez, Mario D, Che, Pao-Lin, Brown, Milton E, Salaita, Khalid, Davis, Michael E

“…Abstract In this study, we used deoxyribozyme (DNAzyme) functionalized gold nanoparticles (AuNPs) to catalytically silence tumor necrosis factor-α (TNF-α)…”
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Delivery of Nox2-NADPH oxidase siRNA with polyketal nanoparticles for improving cardiac function following myocardial infarction by Somasuntharam, Inthirai, Boopathy, Archana V, Khan, Raffay S, Martinez, Mario D, Brown, Milton E, Murthy, Niren, Davis, Michael E

“…Abstract Myocardial infarction (MI) is the most common cause of heart failure (HF), the leading cause of death in the developed world. Oxidative stress due to…”
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Imaging the Activation of Low-Boiling-Point Phase-Change Contrast Agents in the Presence of Tissue Motion Using Ultrafast Inter-frame Activation Ultrasound Imaging by Jing, Bowen, Brown, Milton E., Davis, Michael E., Lindsey, Brooks D.

“…Nanoscale phase-change contrast agents (PCCAs) have been found to have great potential in non-invasive extravascular imaging and therapeutic delivery. However,…”
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Functionalized dendrimer-based delivery of angiotensin type 1 receptor siRNA for preserving cardiac function following infarction by Liu, Jie, Gu, Catherine, Cabigas, E. Bernadette, Pendergrass, Karl D, Brown, Milton E, Luo, Ying, Davis, Michael E

“…Abstract Cardiovascular disease (CVD) is the leading cause of death throughout the world and much pathology is associated with upregulation of inflammatory…”
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Intramyocardial Delivery of Notch Ligand-Containing Hydrogels Improves Cardiac Function and Angiogenesis Following Infarction by Boopathy, Archana V, Martinez, Mario D, Smith, Amanda Walker, Brown, Milton E, García, Andrés J, Davis, Michael E

“…Myocardial infarction (MI) is the leading cause of death worldwide. Notch1 signaling plays a critical role in cardiac development, in survival, cardiogenic…”
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Electrical Stimulation of pediatric cardiac‐derived c‐kit+ progenitor cells improves retention and cardiac function in right ventricular heart failure by Maxwell, Joshua T., Trac, David, Shen, Ming, Brown, Milton E., Davis, Michael E., Chao, Myra S., Supapannachart, Krittin J., Zaladonis, Carly A., Baker, Emily, Li, Martin L., Zhao, Jennifer, Jacobs, Daniel I.

“…Nearly 1 in every 120 children born has a congenital heart defect. Although surgical therapy has improved survival, many of these children go on to develop…”
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The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation by Boopathy, Archana V, Che, Pao Lin, Somasuntharam, Inthirai, Fiore, Vincent F, Cabigas, E. Bernadette, Ban, Kiwon, Brown, Milton E, Narui, Yoshie, Barker, Thomas H, Yoon, Young-Sup, Salaita, Khalid, García, Andrés J, Davis, Michael E

“…Abstract Myocardial infarction is the leading cause of death worldwide and phase I clinical trials utilizing cardiac progenitor cells (CPCs) have shown…”
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