Search Results - "Brown, Matthew A."

Effect of Electrolyte Concentration on the Stern Layer Thickness at a Charged Interface by Brown, Matthew A., Goel, Alok, Abbas, Zareen

“…The chemistry and physics of charged interfaces is regulated by the structure of the electrical double layer (EDL). Herein we quantify the average thickness of…”
Get full text

10 Years of GWAS Discovery: Biology, Function, and Translation by Visscher, Peter M., Wray, Naomi R., Zhang, Qian, Sklar, Pamela, McCarthy, Mark I., Brown, Matthew A., Yang, Jian

“…Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of…”
Get full text

Five Years of GWAS Discovery by VISSCHER, Peter M, BROWN, Matthew A, MCCARTHY, Mark I, JIAN YANG

“…The past five years have seen many scientific and biological discoveries made through the experimental design of genome-wide association studies (GWASs). These…”
Get full text

Brief Report: Intestinal Dysbiosis in Ankylosing Spondylitis by Costello, Mary‐Ellen, Ciccia, Francesco, Willner, Dana, Warrington, Nicole, Robinson, Philip C., Gardiner, Brooke, Marshall, Mhairi, Kenna, Tony J., Triolo, Giovanni, Brown, Matthew A.

“…Objective Ankylosing spondylitis (AS) is a common, highly heritable immune‐mediated arthropathy that occurs in genetically susceptible individuals exposed to…”
Get full text

Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy upon microbiome composition by Yin, Jian, Sternes, Peter Richard, Wang, Mingbang, Song, Jing, Morrison, Mark, Li, Ting, Zhou, Ling, Wu, Xin, He, Fusheng, Zhu, Jian, Brown, Matthew A, Xu, Huji

“…Diverse evidence including clinical, genetic and microbiome studies support a major role of the gut microbiome in the common immune-mediated arthropathy,…”
Get more information

Determination of Surface Potential and Electrical Double-Layer Structure at the Aqueous Electrolyte-Nanoparticle Interface by Brown, Matthew A., Abbas, Zareen, Kleibert, Armin, Green, Richard G., Goel, Alok, May, Sylvio, Squires, Todd M.

“…The structure of the electrical double layer has been debated for well over a century, since it mediates colloidal interactions, regulates surface structure,…”
Get full text

Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study by Leo, Paul J, Madeleine, Margaret M, Wang, Sophia, Schwartz, Stephen M, Newell, Felicity, Pettersson-Kymmer, Ulrika, Hemminki, Kari, Hallmans, Goran, Tiews, Sven, Steinberg, Winfried, Rader, Janet S, Castro, Felipe, Safaeian, Mahboobeh, Franco, Eduardo L, Coutlée, François, Ohlsson, Claes, Cortes, Adrian, Marshall, Mhairi, Mukhopadhyay, Pamela, Cremin, Katie, Johnson, Lisa G, Trimble, Cornelia L, Garland, Suzanne, Tabrizi, Sepehr N, Wentzensen, Nicolas, Sitas, Freddy, Little, Julian, Cruickshank, Maggie, Frazer, Ian H, Hildesheim, Allan, Brown, Matthew A

“…A small percentage of women with cervical HPV infection progress to cervical neoplasia, and the risk factors determining progression are incompletely…”
Get full text

Ethics of genetic testing and research in sport: a position statement from the Australian Institute of Sport by Vlahovich, Nicole, Fricker, Peter A, Brown, Matthew A, Hughes, David

“…As Australia's peak high-performance sport agency, the Australian Institute of Sport (AIS) has developed this position statement to address the implications of…”
Get more information

Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis by Vecellio, Matteo, Chen, Liye, Cohen, Carla J., Cortes, Adrian, Li, Yan, Bonham, Sarah, Selmi, Carlo, Brown, Matthew A., Fischer, Roman, Knight, Julian C., Wordsworth, B. Paul

“…Objective To investigate the functional consequences of the single‐nucleotide polymorphism rs4648889 in a putative enhancer upstream of the RUNX3 promoter…”
Get full text

Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci by van de Bunt, Martijn, Cortes, Adrian, Brown, Matthew A, Morris, Andrew P, McCarthy, Mark I

“…The growing availability of high-quality genomic annotation has increased the potential for mechanistic insights when the specific variants driving common…”
Get full text

Polygenic risk scores and rheumatic diseases by Brown, Matthew A., Li, Zhixiu

“…Including SNPs that show less definitive evidence of association captures a higher proportion of the total heritability of the disease, but also increases the…”
Get full text

Best practices in DNA methylation: lessons from inflammatory bowel disease, psoriasis and ankylosing spondylitis by Whyte, Jessica M, Ellis, Jonathan J, Brown, Matthew A, Kenna, Tony J

“…Advances in genomic technology have enabled a greater understanding of the genetics of common immune-mediated diseases such as ankylosing spondylitis (AS),…”
Get full text

Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis by Okada, Yukinori, Suzuki, Akari, Ikari, Katsunori, Terao, Chikashi, Kochi, Yuta, Ohmura, Koichiro, Higasa, Koichiro, Akiyama, Masato, Ashikawa, Kyota, Kanai, Masahiro, Hirata, Jun, Suita, Naomasa, Teo, Yik-Ying, Xu, Huji, Bae, Sang-Cheol, Takahashi, Atsushi, Momozawa, Yukihide, Matsuda, Koichi, Momohara, Shigeki, Taniguchi, Atsuo, Yamada, Ryo, Mimori, Tsuneyo, Kubo, Michiaki, Brown, Matthew A., Raychaudhuri, Soumya, Matsuda, Fumihiko, Yamanaka, Hisashi, Kamatani, Yoichiro, Yamamoto, Kazuhiko

“…Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from…”
Get full text

Genetics and genomics of ankylosing spondylitis by Thomas, Gethin P, Brown, Matthew A

“…Ankylosing spondylitis (AS) is a common, highly heritable arthropathy, the pathogenesis of which is poorly understood. The mechanism by which the main gene for…”
Get full text

Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1 by Burdon, Kathryn P, Macgregor, Stuart, Hewitt, Alex W, Sharma, Shiwani, Chidlow, Glyn, Mills, Richard A, Danoy, Patrick, Casson, Robert, Viswanathan, Ananth C, Liu, Jimmy Z, Landers, John, Henders, Anjali K, Wood, John, Souzeau, Emmanuelle, Crawford, April, Leo, Paul, Wang, Jie Jin, Rochtchina, Elena, Nyholt, Dale R, Martin, Nicholas G, Montgomery, Grant W, Mitchell, Paul, Brown, Matthew A, Mackey, David A, Craig, Jamie E

“…Jamie Craig and colleagues report a genome-wide association study for advanced open angle glaucoma (OAG). They identify variants near TMCO1 and in CDKN2B-AS1…”
Get full text

Specific Anion Effects on Na+ Adsorption at the Aqueous Solution–Air Interface: MD Simulations, SESSA Calculations, and Photoelectron Spectroscopy Experiments by Olivieri, Giorgia, Parry, Krista M, D’Auria, Raffaella, Tobias, Douglas J, Brown, Matthew A

“…Specific ion effects of the large halide anions have been shown to moderate anion adsorption to the air–water interface (AWI), but little quantitative…”
Get full text

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming by Kochan, Grazyna, Krojer, Tobias, Harvey, David, Fischer, Roman, Chen, Liye, Vollmar, Melanie, von Delft, Frank, Kavanagh, Kathryn L, Brown, Matthew A, Bowness, Paul, Wordsworth, Paul, Kessler, Benedikt M, Oppermann, Udo

“…Endoplasmatic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved in trimming of peptides to an optimal length for presentation by major…”
Get full text

Measure of Surface Potential at the Aqueous–Oxide Nanoparticle Interface by XPS from a Liquid Microjet by Brown, Matthew A, Beloqui Redondo, Amaia, Sterrer, Martin, Winter, Bernd, Pacchioni, Gianfranco, Abbas, Zareen, van Bokhoven, Jeroen A

“…We show that the surface potential at a water–oxide nanoparticle (NP) interface, long considered an immeasurable direct quantity, can be measured by X-ray…”
Get full text

A Dome-Headed Stem Archosaur Exemplifies Convergence among Dinosaurs and Their Distant Relatives by Stocker, Michelle R., Nesbitt, Sterling J., Criswell, Katharine E., Parker, William G., Witmer, Lawrence M., Rowe, Timothy B., Ridgely, Ryan, Brown, Matthew A.

“…Similarities in body plan evolution, such as wings in pterosaurs, birds, and bats or limblessness in snakes and amphisbaenians, can be recognized as classical…”
Get full text

Genotype by sex interactions in ankylosing spondylitis by Li, Zhixiu, McRae, Allan F., Wang, Geng, Ellis, Jonathan J., Whyte, Jessica, Kenna, Tony J., Brown, Matthew A., Evans, David M.

Get full text