Search Results - "Brown, Maryanne"

CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells by Lewis, Nuruddeen D, Muthukumarana, Akalushi, Fogal, Steven E, Corradini, Laura, Stefanopoulos, Dimitria E, Adusumalli, Prathima, Pelletier, Josephine, Panzenbeck, Mark, Berg, Karen, Canfield, Melissa, Cook, Brian N, Razavi, Hossein, Kuzmich, Daniel, Anderson, Shawn, Allard, Devan, Harrison, Paul, Grimaldi, Christine, Souza, Donald, Harcken, Christian, Fryer, Ryan M, Modis, Louise K, Brown, Maryanne L

“…Inflammation is associated with immune cells infiltrating into the inflammatory site and pain. CC chemokine receptor 1 (CCR1) mediates trafficking of…”
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Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3 by Lewis, Nuruddeen D, Haxhinasto, Sokol A, Anderson, Shawn M, Stefanopoulos, Dimitria E, Fogal, Steven E, Adusumalli, Prathima, Desai, Sudha N, Patnaude, Lori A, Lukas, Susan M, Ryan, Kelli R, Slavin, Anthony J, Brown, Maryanne L, Modis, Louise K

“…Sphingosine-1-phosphate (S1P) receptors are critical for lymphocyte egress from secondary lymphoid organs, and S1P receptor modulators suppress lymphocyte…”
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Pathogenic mechanisms and experimental models of multiple sclerosis by Slavin, Anthony, Kelly-Modis, Louise, Labadia, Mark, Ryan, Kelli, Brown, Maryanne L.

“…Multiple sclerosis (MS) is a devastating autoimmune disease that affects more than 1 million people worldwide and severely compromises motor and sensory…”
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Discovery of potent and selective PKC-θ inhibitors by Cywin, Charles L., Dahmann, Georg, Prokopowicz, Anthony S., Young, Erick R.R., Magolda, Ronald L., Cardozo, Mario G., Cogan, Derek A., DiSalvo, Darren, Ginn, John D., Kashem, Mohammed A., Wolak, John P., Homon, Carol A., Farrell, Thomas M., Grbic, Heather, Hu, Hanbo, Kaplita, Paul V., Liu, Lisa H., Spero, Denice M., Jeanfavre, Deborah D., O’Shea, Kathy M., White, Della M., Woska, Joseph R., Brown, Maryanne L.

“…An uHTS campaign was performed to identify selective inhibitors of PKC-θ. Initial triaging of the hit set based on selectivity and historical analysis led to…”
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Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors by Ward, Yancey D, Thomson, David S, Frye, Leah L, Cywin, Charles L, Morwick, Tina, Emmanuel, Michel J, Zindell, Renée, McNeil, Daniel, Bekkali, Younes, Hrapchak, Matt, DeTuri, Molly, Crane, Kathy, White, Della, Pav, Susan, Wang, Yong, Hao, Ming-Hong, Grygon, Christine A, Labadia, Mark E, Freeman, Dorothy M, Davidson, Walter, Hopkins, Jerry L, Brown, Maryanne L, Spero, Denice M

“…The specificity of the immune response relies on processing of foreign proteins and presentation of antigenic peptides at the cell surface. Inhibition of…”
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Increased High-Density Lipoprotein Levels Caused by a Common Cholesteryl-Ester Transfer Protein Gene Mutation by Inazu, Akihiro, Brown, Maryanne L, Hesler, Charles B, Agellon, Luis B, Koizumi, Junji, Takata, Koki, Maruhama, Yoshisuke, Mabuchi, Hiroshi, Tall, Alan R

“…MOST prospective epidemiologic studies have found an inverse correlation between levels of high-density lipoprotein (HDL) and the incidence of atherosclerotic…”
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Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors by Bekkali, Younes, Thomson, David S., Betageri, Raj, Emmanuel, Michel J., Hao, Ming-Hong, Hickey, Eugene, Liu, Weimin, Patel, Usha, Ward, Yancey D., Young, Erick R.R., Nelson, Richard, Kukulka, Alison, Brown, Maryanne L., Crane, Kathy, White, Della, Freeman, Dorothy M., Labadia, Mark E., Wildeson, Jessi, Spero, Denice M.

“…The synthesis and SAR of the first succinyl-nitrile-based compounds as Cathepsin S inhibitors are described. The synthesis and in vitro activities of a series…”
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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket by Tong, Liang, Pav, Susan, White, Della M, Rogers, Sheri, Crane, Kathy M, Cywin, Charles L, Brown, Maryanne L, Pargellis, Christopher A

“…The crystal structure of human p38 mitogen-activated protein (MAP) kinase in complex with a potent and highly specific pyridinyl-imidazole inhibitor has been…”
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Enhancing the Quality of Supportive Supervisory Behavior in Long-term Care Facilities by Hall, Linda McGillis, McGilton, Katherine S., Krejci, Janet, Pringle, Dorothy, Johnston, Erin, Fairley, Laura, Brown, Maryanne

“…The practices of managers and registered nurses (RNs) in long-term care facilities are frequently ineffective in assisting the licensed practical nurses (LPNs)…”
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An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity by Desai, Sudha N., White, Della M., O'Shea, Kathryn M., Brown, Maryanne L., Cywin, Charles L., Spero, Denice M., Panzenbeck, Maret J.

“…Cathepsin S is a major histocompatibility complex (MHC) class II associated invariant chain (Ii) degrading enzyme expressed in antigen presenting cells such as…”
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Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins by Brown, Maryanne L, Inazu, Akihiro, Hesler, Charles B, Agellon, Luis B, Mann, Chris, Whitlock, Mary E, Marcel, Yves L, Milne, Ross W, Koizumi, Junji, Mabuchi, Hiroshi, Takeda, Ryoyu, Tall, Alan R

“…Plasma high density lipoproteins (HDL) are a negative risk factor for atherosclerosis. Increased HDL is sometimes clustered in families, but a genetic basis…”
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Making tradeoffs between the reasons to leave and reasons to stay employed in long-term care homes: Perspectives of licensed nursing staff by McGilton, Katherine S., Boscart, Veronique M., Brown, Maryanne, Bowers, Barbara

“…Turnover of licensed nursing staff in long-term care (LTC) settings (e.g., nursing homes) is a mounting concern and is associated with poor quality of care and…”
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The design of potent hydrazones and disulfides as cathepsin S inhibitors by Cywin, Charles L, Firestone, Raymond A, McNeil, Daniel W, Grygon, Christine A, Crane, Kathryn M, White, Della M, Kinkade, Peter R, Hopkins, Jerry L, Davidson, Walter, Labadia, Mark E, Wildeson, Jessi, Morelock, Maurice M, Peterson, Jeffrey D, Raymond, Ernest L, Brown, Maryanne L, Spero, Denice M

“…The design and synthesis of dipeptidyl disulfides and dipeptidyl benzoylhydrazones as selective inhibitors of the cysteine protease Cathepsin S are described…”
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Protein Kinase C-θ Mediates Negative Feedback on Regulatory T Cell Function by Zanin-Zhorov, Alexandra, Ding, Yi, Kumari, Sudha, Attur, Mukundan, Hippen, Keli L., Brown, Maryanne, Blazar, Bruce R., Abramson, Steven B., Lafaille, Juan J., Dustin, Michael L.

“…T cell receptor (TCR)-dependent regulatory T cell $(T_{reg})$ activity controls effector T cell $(T_{eff})$ function and is inhibited by the inflammatory…”
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Organization of the human cholesteryl ester transfer protein gene by Agellon, Luis B, Quinet, Elaine M, Gillette, Thomas G, Drayna, Dennis T, Brown, Maryanne L, Tall, Alan R

“…The plasma cholesteryl ester transfer protein (CETP) catalyzes the transfer of phospholipids and neutral lipids between the lipoproteins. Thus, this protein…”
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Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors by Ward, Yancey D, Thomson, David S, Frye, Leah L, Cywin, Charles L, Morwick, Tina, Emmanuel, Michel J, Zindell, Renée, McNeil, Daniel, Bekkali, Younes, Girardot, Marc, Hrapchak, Matt, DeTuri, Molly, Crane, Kathy, White, Della, Pav, Susan, Wang, Yong, Hao, Ming-Hong, Grygon, Christine A, Labadia, Mark E, Freeman, Dorothy M, Davidson, Walter, Hopkins, Jerry L, Brown, Maryanne L, Spero, Denice M

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The relationship between care providers' relational behaviors and residents mood and behavior in long-term care settings by McGilton, Katherine S., Sidani, Souraya, Boscart, Veronique M., Guruge, Sepali, Brown, Maryanne

“…Background: Care providers' interactions with residents are an important element in long-term care settings. This study aimed at examining the association…”
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Discovery and optimization of pyrazole amides as antagonists of CCR1 by Harcken, Christian, Sarko, Christopher, Mao, Can, Lord, John, Raudenbush, Brian, Razavi, Hossein, Liu, Pingrong, Swinamer, Alan, Disalvo, Darren, Lee, Thomas, Lin, Siqi, Kukulka, Alison, Grbic, Heather, Patel, Mita, Patel, Monica, Fletcher, Kim, Joseph, David, White, Della, Amodeo, Laura, Berg, Karen, Brown, Maryanne, Thomson, David S.

“…[Display omitted] •A HTS screen for CCR1 antagonists afforded a novel hit containing a pyrazole core.•Multi parameter optimization led to advanced candidate…”
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Identification of novel azaindazole CCR1 antagonist clinical candidates by Harcken, Christian, Kuzmich, Daniel, Cook, Brain, Mao, Can, Disalvo, Darren, Razavi, Hossein, Swinamer, Alan, Liu, Pingrong, Zhang, Qiang, Kukulka, Alison, Skow, Donna, Patel, Mita, Patel, Monica, Fletcher, Kimberly, Sherry, Tara, Joseph, David, Smith, Dustin, Canfield, Melissa, Souza, Donald, Bogdanffy, Matthew, Berg, Karen, Brown, Maryanne

“…[Display omitted] •Scaffold hopping approach led to identification of novel indazole CCR1 antagonists.•Multi parameter optimization led to three clinical…”
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Alternative splicing of the mRNA encoding the human cholesteryl ester transfer protein by Inazu, Akihiro, Quinet, Elaine M, Wang, Suke, Brown, Maryanne L, Stevenson, Susan, Barr, Mark L, Moulin, Philippe, Tall, Alan R

“…The plasma cholesteryl ester transfer protein (CETP) is known to facilitate the transfer of lipids between plasma lipoproteins. The human CETP gene is a…”
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