Search Results - "Brown, Markus A."

TCF7L2 silencing results in altered gene expression patterns accompanied by local genomic reorganization by Brown, Markus A., Dotson, Gabrielle A., Ronquist, Scott, Emons, Georg, Rajapakse, Indika, Ried, Thomas

“…Canonical Wnt signaling is crucial for intestinal homeostasis as TCF4, the major Wnt signaling effector in the intestines, is required for stem cell…”
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Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome by Mao, Xiaojing, Xiong, Zheng-Mei, Xue, Huijing, Brown, Markus A, Gete, Yantenew G, Yu, Reynold, Sun, Linlin, Cao, Kan

“…Hutchinson-Gilford progeria syndrome (HGPS) is a detrimental premature aging disease caused by a point mutation in the human gene. This mutation results in the…”
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Shifting the Focus of Signaling Abnormalities in Colon Cancer by Brown, Markus A, Ried, Thomas

“…Colon cancer tumorigenesis occurs incrementally. The process involves the acquisition of mutations which typically follow an established pattern: activation of…”
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Single-Cell-Derived Primary Rectal Carcinoma Cell Lines Reflect Intratumor Heterogeneity Associated with Treatment Response by Braun, Rüdiger, Anthuber, Lena, Hirsch, Daniela, Wangsa, Darawalee, Lack, Justin, McNeil, Nicole E, Heselmeyer-Haddad, Kerstin, Torres, Irianna, Wangsa, Danny, Brown, Markus A, Tubbs, Anthony, Auslander, Noam, Gertz, E Michael, Brauer, Philip R, Cam, Margaret C, Sackett, Dan L, Habermann, Jens K, Nussenzweig, Andre, Ruppin, Eytan, Zhang, Zhongqiu, Rosenberg, Daniel W, Ried, Thomas

“…The standard treatment of patients with locally advanced rectal cancer consists of preoperative chemoradiotherapy (CRT) followed by surgery. However, the…”
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Identification of Drosophila Mutants Affecting Defense to an Entomopathogenic Fungus by Lu, Hsiao-Ling, Wang, Jonathan B., Brown, Markus A., Euerle, Christopher, St. Leger, Raymond J.

“…Fungi cause the majority of insect disease. However, to date attempts to model host–fungal interactions with Drosophila have focused on opportunistic human…”
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In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli by Srivastava, Rajkamal, González-Prieto, Coral, Lynch, Jason P, Muscolo, Michele E, Lin, Catherine Y, Brown, Markus A, Lemos, Luisa, Shrestha, Anishma, Osburne, Marcia S, Leong, John M, Lesser, Cammie F

“…Engineered smart microbes that deliver therapeutic payloads are emerging as treatment modalities, particularly for diseases with links to the gastrointestinal…”
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Abstract 5492: Comprehensive analysis of the dynamics of aberrant WNT signaling on global gene expression and nuclear structure by Brown, Markus A.

“…Abstract The organization of the genome in the nucleus is complex and dynamic. Features of the nuclear architecture, including the spatial arrangement of…”
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