Search Results - "Brown, Mark D."

Relationship between solute transport properties and tissue morphology in human annulus fibrosus by Travascio, Francesco, Jackson, Alicia R., Brown, Mark D., Gu, Wei Yong

“…Poor nutritional supply to the intervertebral disc is believed to be an important factor leading to disc degeneration. However, little is known regarding…”
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A randomized study of closed wound suction drainage for extensive lumbar spine surgery by BROWN, Mark D, BROOKFIELD, Kathleen F. W

“…A prospective randomized study. To study the risk of infection, hematoma, and neurologic deficits following extensive lumbar spine surgery in patients with or…”
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Contact X-ray Brachytherapy as a sole treatment in selected patients with early rectal cancer – Multi-centre study by Wah Than, Ngu, Mark Pritchard, D., Hughes, David M., Shing Yu, Kai, Minnaar, Helen S., Dhadda, Amandeep, Mills, Jamie, Folkesson, Joakim, Radu, Calin, Duckworth, C.A., Wong, Helen, Ul Haq, Muneeb, Sripadam, Rajaram, Halling-Brown, Mark D., Stewart, Alexandra J., Sun Myint, Arthur

“…•We have evaluated the role of sole Contact X-ray brachytherapy (CXB) as a treatment option for early rectal cancer.•There have been no recently published…”
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Pearls: Patient-generated Pain Drawings by Brown, Mark D.

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Effect of intervertebral disc degeneration on mechanical and electric signals at the interface between disc and vertebra by Zhu, Qiaoqiao, Gao, Xin, Chen, Sihan, Gu, Weiyong, Brown, Mark D.

“…Intervertebral disc (IVD) degeneration is significantly correlated with the changes in structure and material properties of adjacent vertebral bone, possibly…”
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Influences of Nutrition Supply and Pathways on the Degenerative Patterns in Human Intervertebral Disc by Zhu, Qiaoqiao, Gao, Xin, Levene, Howard B, Brown, Mark D, Gu, Weiyong

“…STUDY DESIGN.Investigation of the effects of the impairment of different nutritional pathways on the intervertebral disc degeneration patterns in terms of…”
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Simulation of the Progression of Intervertebral Disc Degeneration Due to Decreased Nutritional Supply by Gu, Weiyong, Zhu, Qiaoqiao, Gao, Xin, Brown, Mark D

“…STUDY DESIGN.Simulate the progression of human disc degeneration. OBJECTIVE.The objective of this study was to quantitatively analyze and simulate the changes…”
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Transport of Vancomycin and Cefepime Into Human Intervertebral Discs: Quantitative Analyses by Zhu, Qiaoqiao, Gao, Xin, Brown, Mark D., Eismont, Frank, Gu, Weiyong

“…STUDY DESIGN.Simulation of antibiotics transport into human intervertebral disc with intravenous infusion. OBJECTIVE.The objective of this study was to…”
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Objective assessment of cancer genes for drug discovery by Patel, Mishal N., Halling-Brown, Mark D., Tym, Joseph E., Workman, Paul, Al-Lazikani, Bissan

“…Key Points Identifying and validating disease-causing genes that are viable as drug targets is a key challenge in drug discovery. Large-scale multi-omics…”
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Effects of diurnal loading on the transport of charged antibiotics into intervertebral discs by Zhu, Qiaoqiao, Gao, Xin, Brown, Mark D., Eismont, Frank, Gu, Weiyong

“…The objective of this study was to quantitatively analyze the effect of diurnal loading on the transport of various charged antibiotics into negatively charged…”
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Association Between Intervertebral Disc Degeneration and Cigarette Smoking: Clinical and Experimental Findings by Jackson, Alicia R., PhD, Dhawale, Arjun A., MD, Brown, Mark D., MD, PhD

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Differential diagnosis of hip disease versus spine disease by Brown, Mark D, Gomez-Marin, Orlando, Brookfield, Kathleen F W, Li, Pamela Stokes

“…Many clinicians find it difficult to differentiate between symptoms caused by a spine disorder or a hip disorder. If surgery is indicated, the order in which…”
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Kinetics of charged antibiotic penetration into human intervertebral discs: A numerical study by Zhu, Qiaoqiao, Gao, Xin, Li, Na, Gu, Weiyong, Eismont, Frank, Brown, Mark D

“…Abstract Little quantitative information exists on the kinetics of charged antibiotic penetration into human intervertebral discs (IVD). This information is…”
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OPTIMAM Mammography Image Database: A Large-Scale Resource of Mammography Images and Clinical Data by Halling-Brown, Mark D, Warren, Lucy M, Ward, Dominic, Lewis, Emma, Mackenzie, Alistair, Wallis, Matthew G, Wilkinson, Louise S, Given-Wilson, Rosalind M, McAvinchey, Rita, Young, Kenneth C

“…Supplemental material is available for this article. Supplemental material is available for this article…”
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Diffusion of antibiotics in intervertebral disc by Jackson, Alicia R., Eismont, Adam, Yu, Lu, Li, Na, Gu, Weiyong, Eismont, Frank, Brown, Mark D.

“…Delivering charged antibiotics to the intervertebral disc is challenging because of the avascular, negatively charged extracellular matrix (ECM) of the tissue…”
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Towards a lightweight generic computational grid framework for biological research by Halling-Brown, Mark D, Moss, David S, Shepherd, Adrian J

“…An increasing number of scientific research projects require access to large-scale computational resources. This is particularly true in the biological field,…”
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Measurement of cadaver lumbar spine motion segment stiffness by BROWN, Mark D, HOLMES, David C, HEINER, Anneliese D

“…Prospective. To measure lumbar spine motion segment stiffness and relate it to the degree of disc degeneration. The association between the instability of the…”
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canSAR: an integrated cancer public translational research and drug discovery resource by Halling-Brown, Mark D., Bulusu, Krishna C., Patel, Mishal, Tym, Joe E., Al-Lazikani, Bissan

“…canSAR is a fully integrated cancer research and drug discovery resource developed to utilize the growing publicly available biological annotation, chemical…”
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Simulation of water content distributions in degenerated human intervertebral discs by Zhu, Qiaoqiao, Gao, Xin, Brown, Mark D., Temple, H. Thomas, Gu, Weiyong

“…ABSTRACT The objective of this study was to investigate the spatial and temporal variations of water content in intervertebral discs during degeneration and…”
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