Search Results - "Brown, M. P."

Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes by Al-Ejeh, F, Kumar, R, Wiegmans, A, Lakhani, S R, Brown, M P, Khanna, K K

“…The DNA-damage response (DDR) pathways consist of interconnected components that respond to DNA damage to allow repair and promote cell survival. The DNA…”
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LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial by Zambrowicz, B, Freiman, J, Brown, P M, Frazier, K S, Turnage, A, Bronner, J, Ruff, D, Shadoan, M, Banks, P, Mseeh, F, Rawlins, D B, Goodwin, N C, Mabon, R, Harrison, B A, Wilson, A, Sands, A, Powell, D R

“…Thirty‐six patients with type 2 diabetes mellitus (T2DM) were randomized 1:1:1 to receive a once‐daily oral dose of placebo or 150 or 300 mg of the dual…”
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Clinical practice guideline exercise and lifestyle in chronic kidney disease by Baker, Luke A, March, Daniel S, Wilkinson, Thomas J, Billany, Roseanne E, Bishop, Nicolette C, Castle, Ellen M, Chilcot, Joseph, Davies, Mark D, Graham-Brown, Matthew P M, Greenwood, Sharlene A, Junglee, Naushad A, Kanavaki, Archontissa M, Lightfoot, Courtney J, Macdonald, Jamie H, Rossetti, Gabriella M K, Smith, Alice C, Burton, James O

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The Interfield Strength Agreement of Left Ventricular Strain Measurements at 1.5 T and 3 T Using Cardiac MRI Feature Tracking by Ayton, Sarah L., Alfuhied, Aseel, Gulsin, Gaurav S., Parke, Kelly S., Wormleighton, Joanne V., Arnold, J. Ranjit, Moss, Alastair J., Singh, Anvesha, Xue, Hui, Kellman, Peter, Graham‐Brown, Matthew P. M., McCann, Gerry P.

“…Background Left ventricular (LV) strain measurements can be derived using cardiac MRI from routinely acquired balanced steady‐state free precession (bSSFP)…”
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Association between native T1 mapping of the kidney and renal fibrosis in patients with IgA nephropathy by Graham-Brown, M P, Singh, A, Wormleighton, J, Brunskill, N J, McCann, G P, Barratt, J, Burton, J O, Xu, G

“…IgA nephropathy (IgAN) is the commonest global cause of glomerulonephritis. Extent of fibrosis, tubular atrophy and glomerulosclerosis predict renal function…”
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Resource efficient aortic distensibility calculation by end to end spatiotemporal learning of aortic lumen from multicentre multivendor multidisease CMR images by Bohoran, Tuan Aqeel, Parke, Kelly S., Graham-Brown, Matthew P. M., Meisuria, Mitul, Singh, Anvesha, Wormleighton, Joanne, Adlam, David, Gopalan, Deepa, Davies, Melanie J., Williams, Bryan, Brown, Morris, McCann, Gerry P., Giannakidis, Archontis

“…Aortic distensibility (AD) is important for the prognosis of multiple cardiovascular diseases. We propose a novel resource-efficient deep learning (DL) model,…”
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Fibro‐inflammatory recovery and type 2 diabetes remission following a low calorie diet but not exercise training: A secondary analysis of the DIASTOLIC randomised controlled trial by Brady, Emer M., Gulsin, Gaurav S., Mirkes, Evgeny M., Parke, Kelly, Kanagala, Prathap, Ng, Leong L., Graham‐Brown, Matthew P. M., Athithan, Lavanya, Henson, Joseph, Redman, Emma, Yang, Jang, Zhao, Lei, Argyridou, Stavroula, Gray, Laura J., Yates, Thomas, Davies, Melanie J., McCann, Gerry P.

“…Aims To investigate the relationship between fibro‐inflammatory biomarkers and cardiovascular structure/function in people with Type 2 Diabetes (T2D) compared…”
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Perceived barriers and facilitators to exercise in kidney transplant recipients: A qualitative study by Billany, Roseanne E., Smith, Alice C., Stevinson, Clare, Clarke, Amy L., Graham‐Brown, Matthew P. M., Bishop, Nicolette C.

“…Background Exercise has the potential to attenuate the high levels of cardiovascular morbidity and mortality present in kidney transplant recipients (KTRs)…”
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The promise and pitfalls of composite endpoints in sepsis and COVID‐19 clinical trials by Brown, P. M., Rogne, Tormod, Solligård, Erik

“…Summary Composite endpoints reveal the tendency for statistical convention to arise locally within subfields. Composites are familiar in cardiovascular trials,…”
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The development and internal pilot trial of a digital physical activity and emotional well-being intervention (Kidney BEAM) for people with chronic kidney disease by Young, Hannah M. L., Castle, Ellen M., Briggs, Juliet, Walklin, Christy, Billany, Roseanne E., Asgari, Elham, Bhandari, Sunil, Bishop, Nicolette, Bramham, Kate, Burton, James O., Campbell, Jackie, Chilcot, Joseph, Cooper, Nicola, Deelchand, Vashist, Graham-Brown, Matthew P. M., Haggis, Lynda, Hamilton, Alexander, Jesky, Mark, Kalra, Philip A., Koufaki, Pelagia, Macdonald, Jamie, McCafferty, Kieran, Nixon, Andrew C., Noble, Helen, Saynor, Zoe L., Taal, Maarten W., Tollitt, James, Wheeler, David C., Wilkinson, Thomas J., Greenwood, Sharlene A.

“…This trial assessed the feasibility and acceptability of Kidney BEAM, a physical activity and emotional well-being self-management digital health intervention…”
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Improving self-management behaviour through a digital lifestyle intervention: An internal pilot study by Lightfoot, Courtney J, Wilkinson, Thomas J, Vadaszy, Noemi, Graham-Brown, Matthew P M, Davies, Melanie J, Yates, Thomas, Smith, Alice C

“…Self-management is a key component of successful chronic kidney disease (CKD) management. Here, we present the findings from the internal pilot of a…”
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The indications for and timing of haemodialysis in critically ill patients with acute kidney injury in Johannesburg, South Africa by Brown, P. M, Redford, L, Omar, S

“…Background. Acute kidney injury (AKI) is common among patients admitted to the intensive care unit (ICU). It is an independent risk factor for morbidity and…”
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A systematic review of immune checkpoint inhibitor-related neurological adverse events and association with anti-neuronal autoantibodies by Salim, Ayesha, Tapia Rico, G, Shaikh, A, Brown, M P

“…: Immune checkpoint inhibitors (ICI) therapy has led to a paradigm shift in cancer drug development and in the clinical evaluation of approaches to combination…”
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Circulating sphingolipids and relationship to cardiac remodelling before and following a low-energy diet in asymptomatic Type 2 Diabetes by Brady, Emer M, Cao, Thong H, Moss, Alastair J, Athithan, Lavanya, Ayton, Sarah L, Redman, Emma, Argyridou, Stavroula, Graham-Brown, Matthew P M, Maxwell, Colleen B, Jones, Donald J L, Ng, Leong, Yates, Thomas, Davies, Melanie J, McCann, Gerry P, Gulsin, Gaurav S

“…Heart failure with preserved ejection fraction (HFpEF) is a heterogenous multi-system syndrome with limited efficacious treatment options. The prevalence of…”
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Association of ambulatory blood pressure with coronary microvascular and cardiac dysfunction in asymptomatic type 2 diabetes by Yeo, Jian L, Gulsin, Gaurav S, Brady, Emer M, Dattani, Abhishek, Bilak, Joanna M, Marsh, Anna-Marie, Sian, Manjit, Athithan, Lavanya, Parke, Kelly S, Wormleighton, Joanne, Graham-Brown, Matthew P M, Singh, Anvesha, Arnold, J Ranjit, Lawson, Claire, Davies, Melanie J, Xue, Hui, Kellman, Peter, McCann, Gerry P

“…Type 2 diabetes (T2D) and hypertension commonly coexist and are associated with subclinical myocardial structural and functional changes. We sought to…”
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The NightLife study - the clinical and cost-effectiveness of thrice-weekly, extended, in-centre nocturnal haemodialysis versus daytime haemodialysis using a mixed methods approach: study protocol for a randomised controlled trial by Hull, Katherine L, Bramham, Kate, Brookes, Cassandra L, Cluley, Victoria, Conefrey, Carmel, Cooper, Nicola J, Eborall, Helen, Fotheringham, James, Graham-Brown, Matthew P M, Gray, Laura J, Mark, Patrick B, Mitra, Sandip, Murphy, Gavin J, Quann, Niamh, Rooshenas, Leila, Warren, Madeleine, Burton, James O

“…In-centre nocturnal haemodialysis (INHD) offers extended-hours haemodialysis, 6 to 8 h thrice-weekly overnight, with the support of dialysis specialist nurses…”
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Energy absorption during projectile perforation of thin steel plates and the kinetic energy of ejected fragments by Dean, J., Dunleavy, C.S., Brown, P.M., Clyne, T.W.

“…This paper concerns energy absorption in thin (0.4 mm) steel plates during perforation by spherical projectiles of hardened steel, at impact velocities between…”
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Defining myocardial fibrosis in haemodialysis patients with non-contrast cardiac magnetic resonance by Graham-Brown, M P, Singh, A S, Gulsin, G S, Levelt, E, Arnold, J A, Stensel, D J, Burton, J O, McCann, G P

“…Extent of myocardial fibrosis (MF) determined using late gadolinium enhanced (LGE) predicts outcomes, but gadolinium is contraindicated in advanced renal…”
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The effects of a digital health intervention on patient activation in chronic kidney disease by Lightfoot, Courtney J., Wilkinson, Thomas J., Sohansoha, Gurneet K., Gillies, Clare L., Vadaszy, Noemi, Ford, Ella C., Davies, Melanie J., Yates, Thomas, Smith, Alice C., Graham-Brown, Matthew P. M.

“…My Kidneys & Me (MK&M), a digital health intervention delivering specialist health and lifestyle education for people with CKD, was developed and its effects…”
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Energy absorption during projectile perforation of lightweight sandwich panels with metallic fibre cores by Dean, J., S-Fallah, A., Brown, P.M., Louca, L.A., Clyne, T.W.

“…This paper concerns energy absorption during projectile penetration of thin, lightweight sandwich panels with metallic fibre cores. The panels were made…”
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