Search Results - "Brown, Leo R."

Implementation of digital remote postoperative monitoring in routine practice: a qualitative study of barriers and facilitators by McLean, Kenneth A, Sgrò, Alessandro, Brown, Leo R, Buijs, Louis F, Mozolowski, Kirsty, Daines, Luke, Cresswell, Kathrin, Potter, Mark A, Bouamrane, Matt-Mouley, Harrison, Ewen M

“…Remote monitoring can strengthen postoperative care in the community and minimise the burden of complications. However, implementation requires a clear…”
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Evaluation of remote digital postoperative wound monitoring in routine surgical practice by McLean, Kenneth A., Sgrò, Alessandro, Brown, Leo R., Buijs, Louis F., Daines, Luke, Potter, Mark A., Bouamrane, Matt-Mouley, Harrison, Ewen M.

“…Remote digital postoperative wound monitoring provides an opportunity to strengthen postoperative community care and minimise the burden of surgical-site…”
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Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series by Vagnildhaug, Ola Magne, Balstad, Trude R., Ottestad, Inger, Bye, Asta, Greil, Christine, Arends, Jann, Baracos, Vickie, Brown, Leo R., Dajani, Olav F., Dolan, Ross D., Fallon, Marie, Fraser, Eilidh, Grzyb, Aleksandra, Hjermstad, Marianne J., Jakobsen, Gunnhild, Kaasa, Stein, McDonald, James, Philips, Iain, Sayers, Judith, Simpson, Melanie R., Sousa, Mariana S., Skipworth, Richard J.E., Laird, Barry J.A., Solheim, Tora S.

“…There is no consensus on the optimal endpoint(s) in cancer cachexia trials. Endpoint variation is an obstacle when comparing interventions and their clinical…”
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Quality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints series by Hjermstad, Marianne J., Jakobsen, Gunnhild, Arends, Jann, Balstad, Trude R., Brown, Leo R., Bye, Asta, Coats, Andrew J.S., Dajani, Olav F., Dolan, Ross D., Fallon, Marie T., Greil, Christine, Grzyb, Alexandra, Kaasa, Stein, Koteng, Lisa H., May, Anne M., McDonald, James, Ottestad, Inger, Philips, Iain, Roeland, Eric J., Sayers, Judith, Simpson, Melanie R., Skipworth, Richard J.E., Solheim, Tora S., Sousa, Mariana S., Vagnildhaug, Ola M., Laird, Barry J.A.

“…The use of patient‐reported outcomes (PROMs) of quality of life (QOL) is common in cachexia trials. Patients' self‐report on health, functioning, wellbeing,…”
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Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series by Brown, Leo R., Sousa, Mariana S., Yule, Michael S., Baracos, Vickie E., McMillan, Donald C., Arends, Jann, Balstad, Trude R., Bye, Asta, Dajani, Olav, Dolan, Ross D., Fallon, Marie T., Greil, Christine, Hjermstad, Marianne J., Jakobsen, Gunnhild, Maddocks, Matthew, McDonald, James, Ottestad, Inger O., Phillips, Iain, Sayers, Judith, Simpson, Melanie R., Vagnildhaug, Ola M., Solheim, Tora S., Laird, Barry J.A., Skipworth, Richard J.E.

“…Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or…”
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Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series by Yule, Michael S., Thompson, Joshua, Leesahatsawat, Khachonphat, Sousa, Mariana S., Anker, Stefan D., Arends, Jann, Balstad, Trude R., Brown, Leo R., Bye, Asta, Dajani, Olav, Fallon, Marie, Hjermstad, Marianne J., Jakobsen, Gunnhild, McDonald, James, McGovern, Josh, Roeland, Eric J., Sayers, Judith, Skipworth, Richard J.E., Ottestad, Inger O., Philips, Iain, Simpson, Melanie R., Solheim, Tora S., Vagnildhaug, Ola Magne, McMillan, Donald, Laird, Barry J.A., Dolan, Ross D.

“…Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered…”
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The prospects of sitting 'end of year' open book exams in the light of COVID-19: A medical student's perspective by Jervis, Christopher G., Brown, Leo R.

“…Medical schools in the UK have been forced to dramatically restructure teaching and assessment amidst the Coronavirus (COVID-19) pandemic. As part of this,…”
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Author response to: Comment on: Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study by Brown, Leo R, Crumley, Andrew B, Skipworth, Richard J E

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Author response to: Comment on: Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study by Brown, Leo R, Crumley, Andrew B, Skipworth, Richard J E

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Temporal Trends in the Investigation, Management and Outcomes of Acute Appendicitis over 15 Years in the North of England: A Retrospective Cohort Study by Bhaskar, Jared, McLean, Ross C., Bhaskar, Keir, Brown, Leo R.

“…Background Acute appendicitis is a common surgical emergency with an estimated lifetime prevalence of 8.6% for males and 6.7% for females. Despite the…”
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Safe surfaces by Brown, Leo R

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Prognostic Biomarkers of Systemic Inflammation in Non-Small Cell Lung Cancer: A Narrative Review of Challenges and Opportunities by Stares, Mark, Brown, Leo R, Abhi, Dhruv, Phillips, Iain

“…Non-small cell lung cancer (NSCLC) is a common malignancy and is associated with poor survival outcomes. Biomarkers of systemic inflammation derived from blood…”
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In reply to Limaye et al. (2020) by Jervis, Christopher G., Brown, Leo R.

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The prognostic impact of pre-treatment cachexia in resectional surgery for oesophagogastric cancer: a meta-analysis and meta-regression by Brown, Leo R, Sayers, Judith, Yule, Michael S, Drake, Thomas M, Dolan, Ross D, McMillan, Donald C, Laird, Barry J A, Wigmore, Stephen J, Skipworth, Richard J E

“…Abstract Background Cancer cachexia is not purely an end-stage phenomenon and can influence the outcomes of patients with potentially curable disease. This…”
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Decision analysis of minimally invasive management options for cholecysto-choledocholithiasis by Bradley, Alison, Sami, Sharukh, Hemadasa, Niroshini, Macleod, Anne, Brown, Leo R., Apollos, Jeyakumar

“…Background The management of cholecysto-choledocholithiasis is controversial with the risks and benefits of one versus two-stage approaches debated. This study…”
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Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study by Brown, Leo R, Thomson, Georgina G, Gardner, Ellen, Chien, Siobhan, McGovern, Josh, Dolan, Ross D, McSorley, Stephen T, Forshaw, Matthew J, McMillan, Donald C, Wigmore, Stephen J, Crumley, Andrew B, Skipworth, Richard J E

“…Abstract Background Features of cancer cachexia adversely influence patient outcomes, yet few currently inform clinical decision-making. This study assessed…”
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Commentary: “Closure of mesenteric defects is associated with a higher incidence of small bowel obstruction due to adhesions after laparoscopic antecolic Roux-en-y gastric bypass” by Sami, Sharukh, Brown, Leo R.

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Central neural mechanisms of cancer cachexia by Yule, Michael S, Brown, Leo R, Skipworth, Richard J E, Laird, Barry J A

“…Cachexia is a devasting syndrome which impacts a large number of patients with cancer. This review aims to provide a comprehensive overview of the central…”
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Letter to the Editor: “Long-Term Results after Laparoscopic Sleeve Gastrectomy with Concomitant Posterior Cruroplasty: 5-Year Follow-up” by Baldock, Thomas E., Brown, Leo R., McLean, Ross C.

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The impact of surgical subspecialization on patient outcomes following emergency colorectal resections in the north of England: a retrospective cohort study by Young, John, Brown, Leo R., Thomas, Christophe L. G., McCallum, Iain J. D., McLean, Ross C.

“…Aim Emergency colorectal surgery is associated with significant morbidity and mortality. Most general surgeons have a subspecialty, which forms the focus of…”
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