Search Results - "Brown, Kyle E."

ACG Clinical Guideline: Hereditary Hemochromatosis by Kowdley, Kris V, Brown, Kyle E, Ahn, Joseph, Sundaram, Vinay

“…Hereditary hemochromatosis (HH) is one of the most common genetic disorders among persons of northern European descent. There have been recent advances in the…”
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Iron-Induced Liver Injury: A Critical Reappraisal by Bloomer, Steven A, Brown, Kyle E

“…Iron is implicated in the pathogenesis of a number of human liver diseases. Hereditary hemochromatosis is the classical example of a liver disease caused by…”
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A thorny matter: Spur cell anemia by Sharma, Ruchi, Holman, Carol J., Brown, Kyle E.

“…Spur cell anemia (SCA) is an acquired form of non-autoimmune hemolytic anemia that occurs in advanced liver disease. It is characterized by the presence of…”
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Hepatitis C Virus Infection and Hepatic Stellate Cell Activation Downregulate miR-29: miR-29 Overexpression Reduces Hepatitis C Viral Abundance in Culture by Bandyopadhyay, Sarmistha, Friedman, Robin C., Marquez, Rebecca T., Keck, Kathy, Kong, Benjamin, Icardi, Michael S., Brown, Kyle E., Burge, Christopher B., Schmidt, Warren N., Wang, Yulei, McCaffrey, Anton P.

“…Background. Chronic hepatitis C virus (HCV)-induced liver fibrosis involves upregulation of transforming growth factor (TGF)-ß and subsequent hepatic stellate…”
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Biliverdin inhibits hepatitis C virus nonstructural 3/4A protease activity: Mechanism for the antiviral effects of heme oxygenase? by Zhu, Zhaowen, Wilson, Anne T., Luxon, Bruce A., Brown, Kyle E., Mathahs, M. Meleah, Bandyopadhyay, Sarmistha, McCaffrey, Anton P., Schmidt, Warren N.

“…Induction of heme oxygenase‐1 (HO‐1) inhibits hepatitis C virus (HCV) replication. Of the products of the reaction catalyzed by HO‐1, iron has been shown to…”
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Clinical Factors Associated with Hepatocellular Iron Deposition in End-stage Liver Disease by Fierro-Fine, Amelia, Guerin, Leana, Hicsasmaz, Hasan, Brown, Kyle E.

“…Background and Aims:Hepatocellular iron accumulation in patients with chronic liver disease has been linked to adverse outcomes. The objective of this study…”
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Interventions and outcomes of treatment of postbanding ulcer hemorrhage after endoscopic band ligation: a single-center case series by Tierney, Amber, MD, Toriz, Bertha E., MD, Mian, Somia, MD, Brown, Kyle E., MD

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Hereditary Hemochromatosis: Missed Diagnosis or Misdiagnosis? by Cherfane, Cynthia E., MD, Hollenbeck, Ryan D., MD, Go, Jorge, MD, MSc, Brown, Kyle E., MD, MSc

“…Abstract Background Hereditary hemochromatosis is a disorder that can cause iron overload and organ damage. Hereditary hemochromatosis is characterized by…”
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Spleen size change after hepatitis C treatment: a simple parameter to predict clinical outcomes by Prakash, Shahana, Kinder, Kyle, Brown, Kyle E

“…Portal hypertension contributes to splenomegaly in cirrhotic patients. Reduction in spleen size may represent improvement in portal hypertension. The goal was…”
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Hepcidin and Iron Metabolism in Experimental Liver Injury by Bloomer, Steven A., Brown, Kyle E.

“…The liver plays a pivotal role in the regulation of iron metabolism through its ability to sense and respond to iron stores by release of the hormone hepcidin…”
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S1386 The National Trends and Hospitalizations of Patients with Hereditary Hemochromatosis in the United States: Insights From the National Inpatient Sample by Sohail, Abdullah, Naseem, Khadija, Khan, Ahmad, Brown, Kyle E.

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S1367 Underlying Etiology of Chronic Liver Disease Impacts Serum Hepcidin Levels: A Meta-Analysis by Sharma, Ruchi, Murali, Arvind R., Brown, Kyle E.

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S1337 Hepcidin Levels Are Suppressed Despite an Intact Hepcidin Iron Axis in Chronic Viral Hepatitis: A Meta-Analysis by Sharma, Ruchi, Murali, Arvind R., Brown, Kyle E.

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Down-Regulation of Heme Oxygenase-1 by Hepatitis C Virus Infection In Vivo and by the In Vitro Expression of Hepatitis C Core Protein by Abdalla, Maher Y., Britigan, Bradley E., Wen, Feng, Icardi, Michael, McCormick, Michael L., LaBrecque, Douglas R., Voigt, Michael, Brown, Kyle E., Schmidt, Warren N.

“…Antioxidant enzymes, including heme oxygenase (HO)-1, are an important line of defense against oxidant-mediated liver injury. Because hepatitis C virus (HCV)…”
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Serum hepcidin levels in chronic liver disease: a systematic review and meta-analysis by Sharma, Ruchi, Zhao, Weidan, Zafar, Yousaf, Murali, Arvind R, Brown, Kyle E

“…Dysregulation of hepcidin-iron axis is presumed to account for abnormal iron status in patients with chronic liver disease (CLD). Our aim is to determine the…”
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Immunohistochemical Detection of Myeloperoxidase and Its Oxidation Products in Kupffer Cells of Human Liver by Brown, Kyle E., Brunt, Elizabeth M., Heinecke, Jay W.

“…Oxidative damage to tissue proteins has been implicated in the pathogenesis of liver disease, but the mechanisms that promote oxidation in vivo are unclear…”
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S379 Successful Use of a Novel Through-the Scope Suturing Device to Close a Duodenal Fistula Caused by Foreign Body Penetration by Sohail, Abdullah, Naseem, Khadija, Brindise, Elizabeth, Brown, Kyle E., Gerke, Henning

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Elevated aminotransferases in a 62-year-old woman by Prakash, Shahana, Moore, Steven, Snow, Anthony, Brown, Kyle E.

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Renal Iron Accumulation and Oxidative Injury With Aging: Effects of Treatment With an Iron Chelator by Bloomer, Steven A, Brown, Kyle E, Kregel, Kevin C

“…Abstract Dysregulation of iron metabolism in the kidney may contribute to age-related increases in renal oxidative stress and dysfunction. This study assessed…”
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Liver iron stores and effectors of ferroptosis are dependent on age and sex by Bloomer, Steven A, Wagner, Brett A, Buettner, Garry R, Brown, Kyle E

“…Ferroptosis is a form of cell death characterized by a pro-oxidative cellular milieu and iron-dependent lipid peroxidation. Ferroptosis has been implicated in…”
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