Search Results - "Brown, Kevin"

Interstitial lung disease associated with systemic sclerosis (SSc-ILD) by Cottin, Vincent, Brown, Kevin K

“…Systemic sclerosis (SSc) is a rare connective tissue disease with a heterogeneous clinical course. Interstitial lung disease (ILD) is a common manifestation of…”
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Estimates of SARS-CoV-2 Omicron Variant Severity in Ontario, Canada by Ulloa, Ana Cecilia, Buchan, Sarah A, Daneman, Nick, Brown, Kevin A

“…This study examines hospitalizations and deaths associated with the SARS-CoV-2 Omicron variant compared with matched patients infected with the Delta variant…”
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VITT and Second Doses of Covid-19 Vaccine by Lacy, Joanne, Pavord, Sue, Brown, Kevin E

“…Forty persons in whom thrombosis and thrombocytopenia had developed after an initial ChAdOx1 nCoV-19 vaccination were given a second dose of a Covid-19…”
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Regioselective Arylboration of Isoprene and Its Derivatives by Pd/Cu Cooperative Catalysis by Smith, Kevin B, Brown, M. Kevin

“…A method for the regio­selective aryl­boration of isoprene and its derivatives is presented. These reactions allow for the synthesis of useful building blocks…”
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High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities by Hart, Traver, Chandrashekhar, Megha, Aregger, Michael, Steinhart, Zachary, Brown, Kevin R., MacLeod, Graham, Mis, Monika, Zimmermann, Michal, Fradet-Turcotte, Amelie, Sun, Song, Mero, Patricia, Dirks, Peter, Sidhu, Sachdev, Roth, Frederick P., Rissland, Olivia S., Durocher, Daniel, Angers, Stephane, Moffat, Jason

“…The ability to perturb genes in human cells is crucial for elucidating gene function and holds great potential for finding therapeutic targets for diseases…”
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Unequal evolutionary conservation of human protein interactions in interologous networks by Brown, Kevin R, Jurisica, Igor

“…Protein-protein interaction (PPI) networks have been transferred between organisms using interologs, allowing model organisms to supplement the interactomes of…”
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Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant by Lopez Bernal, Jamie, Andrews, Nick, Gower, Charlotte, Gallagher, Eileen, Simmons, Ruth, Thelwall, Simon, Stowe, Julia, Tessier, Elise, Groves, Natalie, Dabrera, Gavin, Myers, Richard, Campbell, Colin N.J, Amirthalingam, Gayatri, Edmunds, Matt, Zambon, Maria, Brown, Kevin E, Hopkins, Susan, Chand, Meera, Ramsay, Mary

“…The B.1.617.2 (delta) Covid-19 variant has surged in India and spread worldwide. In a test-negative case–control study, the effectiveness of two doses of…”
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Catalytic Enantioselective Arylboration of Alkenylarenes by Logan, Kaitlyn M., Brown, M. Kevin

“…A method for the catalytic enantioselective arylboration of alkenylarenes is disclosed. The reaction leads to the formation of 1,1‐diarylalkanes that also…”
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Catalytic Enantioselective Diarylation of Alkenes by You, Wei, Brown, M. Kevin

“…A method for the catalytic enantioselective diarylation of alkenes is presented. The method allowed for the synthesis of highly enantioenriched…”
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Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance by Marcotte, Richard, Sayad, Azin, Brown, Kevin R., Sanchez-Garcia, Felix, Reimand, Jüri, Haider, Maliha, Virtanen, Carl, Bradner, James E., Bader, Gary D., Mills, Gordon B., Pe’er, Dana, Moffat, Jason, Neel, Benjamin G.

“…Large-scale genomic studies have identified multiple somatic aberrations in breast cancer, including copy number alterations and point mutations. Still,…”
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Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss by Brown, Kevin D., Maqsood, Sadia, Huang, Jing-Yi, Pan, Yong, Harkcom, William, Li, Wei, Sauve, Anthony, Verdin, Eric, Jaffrey, Samie R.

“…Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia neurites that innervate cochlear hair cells. Nicotinamide adenine…”
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For-profit long-term care homes and the risk of COVID-19 outbreaks and resident deaths by Stall, Nathan M, Jones, Aaron, Brown, Kevin A, Rochon, Paula A, Costa, Andrew P

“…Long-term care (LTC) homes have been the epicentre of the coronavirus disease 2019 (COVID-19) pandemic in Canada to date. Previous research shows that…”
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Association Between Nursing Home Crowding and COVID-19 Infection and Mortality in Ontario, Canada by Brown, Kevin A, Jones, Aaron, Daneman, Nick, Chan, Adrienne K, Schwartz, Kevin L, Garber, Gary E, Costa, Andrew P, Stall, Nathan M

“…Nursing home residents have been disproportionately affected by coronavirus disease 2019 (COVID-19). Prevention recommendations emphasize frequent testing of…”
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Cyclobutane and Cyclobutene Synthesis: Catalytic Enantioselective [2+2] Cycloadditions by Xu, Yao, Conner, Michael L., Brown, M. Kevin

“…Cyclobutanes and cyclobutenes are important structural motifs found in numerous biologically significant molecules, and they are useful intermediates for…”
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Measuring error rates in genomic perturbation screens: gold standards for human functional genomics by Hart, Traver, Brown, Kevin R, Sircoulomb, Fabrice, Rottapel, Robert, Moffat, Jason

“…Technological advancement has opened the door to systematic genetics in mammalian cells. Genome‐scale loss‐of‐function screens can assay fitness defects…”
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Idiopathic Pulmonary Fibrosis: Epidemiology, Diagnosis andOutcomes by Wakwaya, Yosafe, Brown, Kevin K.

“…The incidence and prevalence of idiopathic pulmonary fibrosis (IPF) is increasing worldwide. This, combined with its poor prognosis and unpredictable natural…”
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Sulfonate N‐Heterocyclic Carbene–Copper Complexes: Uniquely Effective Catalysts for Enantioselective Synthesis of C−C, C−B, C−H, and C−Si Bonds by Hoveyda, Amir H., Zhou, Yuebiao, Shi, Ying, Brown, M. Kevin, Wu, Hao, Torker, Sebastian

“…A copper‐based complex that contains a sulfonate N‐heterocyclic carbene ligand was first reported 15 years ago. Since then, these organometallic entities have…”
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Meta-Analysis of Antibiotics and the Risk of Community-Associated Clostridium difficile Infection by BROWN, Kevin A, KHANAFER, Nagham, DANEMAN, Nick, FISMAN, David N

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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S-Gene Target Failure as a Marker of Variant B.1.1.7 Among SARS-CoV-2 Isolates in the Greater Toronto Area, December 2020 to March 2021 by Brown, Kevin A, Gubbay, Jonathan, Hopkins, Jessica, Patel, Samir, Buchan, Sarah A, Daneman, Nick, Goneau, Lee William

“…This study determined the spread of the B.1.1.7 SARs-CoV-2 variant in the Greater Toronto Area over 4 months by tracking S-gene target failure as marker…”
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Association of Age and Pediatric Household Transmission of SARS-CoV-2 Infection by Paul, Lauren A, Daneman, Nick, Schwartz, Kevin L, Science, Michelle, Brown, Kevin A, Whelan, Michael, Chan, Ellen, Buchan, Sarah A

“…As a result of low numbers of pediatric cases early in the COVID-19 pandemic, pediatric household transmission of SARS-CoV-2 remains an understudied topic. To…”
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