Search Results - "Brown, Kathleen C."

Bioavailability of capsaicin and its implications for drug delivery by Rollyson, William D., Stover, Cody A., Brown, Kathleen C., Perry, Haley E., Stevenson, Cathryn D., McNees, Christopher A., Ball, John G., Valentovic, Monica A., Dasgupta, Piyali

“…The dietary compound capsaicin is responsible for the “hot and spicy” taste of chili peppers and pepper extracts. It is a valuable pharmacological agent with…”
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The e-liquid flavoring cinnamaldehyde induces cellular stress responses in human proximal tubule (HK-2) kidney cells by Cox, Ashley, Brown, Kathleen C., Bender, Christopher, Valentovic, Monica A.

“…Flavored e-liquid use has become popular among e-cigarette users recently, but the effects of such products outside the lung are not well characterized. In…”
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Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis by Egleton, Richard D, Brown, Kathleen C, Dasgupta, Piyali

“…Nicotinic acetylcholine receptors (nAChRs) constitute a heterogeneous family of ion channels that mediate fast synaptic transmission in neurons. They have also…”
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Anticancer Activity of Natural and Synthetic Capsaicin Analogs by Friedman, Jamie R, Nolan, Nicholas A, Brown, Kathleen C, Miles, Sarah L, Akers, Austin T, Colclough, Kate W, Seidler, Jessica M, Rimoldi, John M, Valentovic, Monica A, Dasgupta, Piyali

“…The nutritional compound capsaicin is the major spicy ingredient of chili peppers. Although traditionally associated with analgesic activity, recent studies…”
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Radiocontrast Agent Diatrizoic Acid Induces Mitophagy and Oxidative Stress via Calcium Dysregulation by Ward, Dakota B, Brown, Kathleen C, Valentovic, Monica A

“…Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital associated kidney damage. Potential mechanisms of CI-AKI may involve…”
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Capsaicinoids: Multiple effects on angiogenesis, invasion and metastasis in human cancers by Friedman, Jamie R., Richbart, Stephen D., Merritt, Justin C., Brown, Kathleen C., Denning, Krista L., Tirona, Maria T., Valentovic, Monica A., Miles, Sarah L., Dasgupta, Piyali

“…Cancer progression is a complex multistep process comprising of angiogenesis of the primary tumor, its invasion into the surrounding stroma and its migration…”
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The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway by CHEN, JIANCHU, CHEN, ALLEN Y, HUANG, HAIZHI, YE, XINGQIAN, ROLLYSON, WILLIAM D, PERRY, HALEY E, BROWN, KATHLEEN C, ROJANASAKUL, YON, RANKIN, GARY O, DASGUPTA, PIYALI, CHEN, YI CHARLIE

“…Despite its importance, the death rate of ovarian cancer has remained unchanged over the past five decades, demanding an improvement in prevention and…”
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Nicotine Induces the Up-regulation of the α7-Nicotinic Receptor (α7-nAChR) in Human Squamous Cell Lung Cancer Cells via the Sp1/GATA Protein Pathway by Brown, Kathleen C., Perry, Haley E., Lau, Jamie K., Jones, Dennie V., Pulliam, Joseph F., Thornhill, Brent A., Crabtree, Clayton M., Luo, Haitao, Chen, Yi. Charlie, Dasgupta, Piyali

“…Nicotine, the addictive component of cigarettes, promotes lung cancer proliferation via the α7-nicotinic acetylcholine receptor (α7-nAChR) subtype. The present…”
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Anticancer Activity of Region B Capsaicin Analogs by Brown, Kathleen C., Modi, Kushal J., Light, Reagan S., Cox, Ashley J., Long, Timothy E., Gadepalli, Rama S., Rimoldi, John M., Miles, Sarah L., Rankin, Gary, Valentovic, Monica, Denning, Krista L., Tirona, Maria T., Finch, Paul T., Hess, Joshua A., Dasgupta, Piyali

“…The heterocyclic vanilloid compound capsaicin is responsible for the spicy and pungent flavor of chili peppers. Several convergent studies have shown that…”
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Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway by Lau, Jamie K., Brown, Kathleen C., Dom, Aaron M., Witte, Theodore R., Thornhill, Brent A., Crabtree, Clayton M., Perry, Haley E., Brown, J. Michael, Ball, John G., Creel, Rebecca G., Damron, C. Luke, Rollyson, William D., Stevenson, Cathryn D., Hardman, W. Elaine, Valentovic, Monica A., Carpenter, A. Betts, Dasgupta, Piyali

“…Capsaicin, the pungent ingredient of chili peppers, displays potent anti-neoplastic activity in a wide array of human cancer cells. The present manuscript…”
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mTOR Regulation of N-Myc Downstream Regulated 1 (NDRG1) Phosphorylation in Clear Cell Renal Cell Carcinoma by Valluri, Anisha, Wellman, Jessica, McCallister, Chelsea L, Brown, Kathleen C, Lawrence, Logan, Russell, Rebecca, Jensen, James, Denvir, James, Valentovic, Monica A, Denning, Krista L, Salisbury, Travis B

“…The mechanistic target of rapamycin (mTOR) kinase is a component of two signaling complexes that are known as mTOR complex 1 (mTORC1) and mTORC2. We sought to…”
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Pet Ownership and Quality of Life: A Systematic Review of the Literature by Scoresby, Kristel J, Strand, Elizabeth B, Ng, Zenithson, Brown, Kathleen C, Stilz, Charles Robert, Strobel, Kristen, Barroso, Cristina S, Souza, Marcy

“…Pet ownership is the most common form of human-animal interaction, and anecdotally, pet ownership can lead to improved physical and mental health for owners…”
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The Flavoring Agent Ethyl Vanillin Induces Cellular Stress Responses in HK-2 Cells by Cox, Ashley J, Brown, Kathleen C, Valentovic, Monica A

“…Flavored e-cigarettes are a popular alternative to cigarette smoking; unfortunately, the extrapulmonary effects are not well-characterized. Human proximal…”
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Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway by Brown, Kathleen C, Witte, Ted R, Hardman, W Elaine, Luo, Haitao, Chen, Yi C, Carpenter, A Betts, Lau, Jamie K, Dasgupta, Piyali

“…Small cell lung cancer (SCLC) is characterized by rapid progression and low survival rates. Therefore, novel therapeutic agents are urgently needed for this…”
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Angiogenic activity of nicotinic acetylcholine receptors: implications in tobacco-related vascular diseases by Egleton, Richard D, Brown, Kathleen C, Dasgupta, Piyali

“…Cigarette smoking bears a strong etiological association with many neovascularization-related diseases like cancer, cardiovascular disease and macular…”
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Using a consumer-based wearable activity tracker for physical activity goal setting and measuring steps in pregnant women with gestational diabetes mellitus: exploring acceptance and validity by Ehrlich, Samantha F., Maples, Jill M., Barroso, Cristina S., Brown, Kathleen C., Bassett, David R., Zite, Nikki B., Fortner, Kimberly B.

“…Abstract Background Activity monitoring devices may be used to facilitate goal-setting, self-monitoring, and feedback towards a step-based physical activity…”
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Occupational stress, job satisfaction and job performance among hospital nurses in Kampala, Uganda by NABIRYE, ROSE C., BROWN, KATHLEEN C., PRYOR, ERICA R., MAPLES, ELIZABETH H.

“…nabirye r.c., brown k.c., pryor e.r. & maples e.h. (2011) Journal of Nursing Management19, 760–768
Occupational stress, job satisfaction and job performance…”
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Cat and/or Dog Ownership, Cardiovascular Disease, and Obesity: A Systematic Review by Barroso, Cristina S, Brown, Kathleen C, Laubach, David, Souza, Marcy, Daugherty, Linda M, Dixson, Melanie

“…Pet ownership, the most common human-animal interaction, is believed to bestow positive health benefits onto pet owners. However, there is limited research on…”
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Nicotinic acetylcholine receptor signaling in atherogenesis by Santanam, Nalini, Thornhill, Brent A, Lau, Jamie K, Crabtree, Clayton M, Cook, Carla R, Brown, Kathleen C, Dasgupta, Piyali

“…Abstract Smoking is a major risk factor for the development of atherosclerosis, stroke and myocardial infarction. Cigarette smoke consists of a complex mixture…”
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Role of Free Radicals and Biotransformation in Trichloronitrobenzene-Induced Nephrotoxicity In Vitro by Rankin, Gary O, Tyree, Connor, Pope, Deborah, Tate, Jordan, Racine, Christopher, Anestis, Dianne K, Brown, Kathleen C, Dial, Mason, Valentovic, Monica A

“…This study determined the comparative nephrotoxic potential of four trichloronitrobenzenes (TCNBs) (2,3,4-; 2,4,5-; 2,4,6-; and 3,4,5-TCNB) and explored the…”
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