Search Results - "Brown, Karen E"

Chronic kidney disease in type 2 diabetes: Implications for managing glycaemic control, cardiovascular and renal risk by Stephens, Jeffrey W., Brown, Karen E., Min, Thinzar

“…This review examines the current literature relating to diabetes related kidney disease (DKD) and the optimal management of cardio‐renal risk. DKD develops in…”
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Beyond the Individual: Community‐Centric Approaches to Increase Diversity in Biomedical Research by Brown, Karen E., Fohner, Alison E., Woodahl, Erica L.

“…Community‐centric approaches to engage underrepresented populations—including community engagement, community‐level consent practices, and capacity development…”
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Active genes dynamically colocalize to shared sites of ongoing transcription by Fraser, Peter, Osborne, Cameron S, Chakalova, Lyubomira, Brown, Karen E, Carter, David, Horton, Alice, Debrand, Emmanuel, Goyenechea, Beatriz, Mitchell, Jennifer A, Lopes, Susana, Reik, Wolf

“…The intranuclear position of many genes has been correlated with their activity state, suggesting that migration to functional subcompartments may influence…”
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A high-resolution map of transcriptional repression by Liang, Ziwei, Brown, Karen E, Carroll, Thomas, Taylor, Benjamin, Vidal, Isabel Ferreirós, Hendrich, Brian, Rueda, David, Fisher, Amanda G, Merkenschlager, Matthias

“…Turning genes on and off is essential for development and homeostasis, yet little is known about the sequence and causal role of chromatin state changes during…”
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Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development by Landeira, David, Bagci, Hakan, Malinowski, Andrzej R., Brown, Karen E., Soza-Ried, Jorge, Feytout, Amelie, Webster, Zoe, Ndjetehe, Elodie, Cantone, Irene, Asenjo, Helena G., Brockdorff, Neil, Carroll, Thomas, Merkenschlager, Matthias, Fisher, Amanda G.

“…Jarid2 is part of the Polycomb Repressor complex 2 (PRC2) responsible for genome-wide H3K27me3 deposition. Unlike other PRC2-deficient embryonic stem cells…”
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Ensuring equity: Pharmacogenetic implementation in rural and tribal communities by Leitch, Tianna M, Killam, Shayna R, Brown, Karen E, Katseanes, Kirk C, George, Kathleen M, Schwanke, Corbin, Loveland, Joshua, Elias, Abdallah F, Haney, Kerry, Krebsbach, Kate, Muzquiz, LeeAnna I, Trinidad, Susan B, Woodahl, Erica L

“…Implementation strategies for pharmacogenetic testing have been largely limited to major academic medical centers and large health systems, threatening to…”
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Bioluminescence imaging of Cyp1a1-luciferase reporter mice demonstrates prolonged activation of the aryl hydrocarbon receptor in the lung by Veland, Nicolas, Gleneadie, Hannah J., Brown, Karen E., Sardini, Alessandro, Pombo, Joaquim, Dimond, Andrew, Burns, Vanessa, Sarkisyan, Karen, Schiering, Chris, Webster, Zoe, Merkenschlager, Matthias, Fisher, Amanda G.

“…Aryl hydrocarbon receptor (AHR) signalling integrates biological processes that sense and respond to environmental, dietary, and metabolic challenges to ensure…”
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Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion by Piccolo, Francesco M., Bagci, Hakan, Brown, Karen E., Landeira, David, Soza-Ried, Jorge, Feytout, Amelie, Mooijman, Dylan, Hajkova, Petra, Leitch, Harry G., Tada, Takashi, Kriaucionis, Skirmantas, Dawlaty, Meelad M., Jaenisch, Rudolf, Merkenschlager, Matthias, Fisher, Amanda G.

“…Genomic imprinting directs the allele-specific marking and expression of loci according to their parental origin. Differential DNA methylation at imprinted…”
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Dynamic Repositioning of Genes in the Nucleus of Lymphocytes Preparing for Cell Division by Brown, Karen E, Baxter, Jonathan, Graf, Daniel, Merkenschlager, Matthias, Fisher, Amanda G

“…We show that several transcriptionally inactive genes localize to centromeric heterochromatin in the nucleus of cycling but not quiescent (noncycling) primary…”
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Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All by Venkatakrishnan, Karthik, Brown, Karen E., Giacomini, Kathleen M., Graaf, Piet H.

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Keeping pace with CYP2D6 haplotype discovery: innovative methods to assign function by Brown, Karen E, Staples, Jack W, Woodahl, Erica L

“…The discovery of haplotypes with unknown or uncertain function in the  pharmacogene is outpacing the capabilities of traditional and approaches to characterize…”
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A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation by Seitan, Vlad C., Hao, Bingtao, Tachibana-Konwalski, Kikuë, Lavagnolli, Thais, Mira-Bontenbal, Hegias, Brown, Karen E., Teng, Grace, Carroll, Tom, Terry, Anna, Horan, Katie, Marks, Hendrik, Adams, David J., Schatz, David G., Aragon, Luis, Fisher, Amanda G., Krangel, Michael S., Nasmyth, Kim, Merkenschlager, Matthias

“…Cohesin role in T-cell differentiation Cohesin is well known as the protein complex that holds sister chromatids together after replication so that they are…”
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Reprogramming lineage identity through cell–cell fusion by Brown, Karen E, Fisher, Amanda G

“…•Cell–cell fusion is a tractable system for studying the earliest events in lineage reprogramming.•There is untapped potential to combine cell–cell fusion and…”
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Barriers and facilitators of the use of clinical informatics resources to facilitate pharmacogenomic implementation in resource-limited settings by Bosic-Reiniger, Jade, Martin, James L, Brown, Karen E, Anderson, Heather D, Blackburn, Hayley, Kao, David P, Trinkley, Katy E, Woodahl, Erica L, Aquilante, Christina L

“…Understand perceived barriers to and facilitators of using clinical informatics applications for pharmacogenomic (PGx) implementation in resource-limited…”
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Chromatin folding and gene expression: new tools to reveal the spatial organization of genes by Brown, Karen E

“…An important aim in biology is to understand how gene expression is regulated in the context of chromatin. Much progress has been made towards cracking the…”
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Atypical heterochromatin organization and replication are rapidly acquired by somatic cells following fusion-mediated reprogramming by mouse ESCs by Brown, Karen E, Bagci, Hakan, Soza-Ried, Jorge, Fisher, Amanda G

“…We recently reported that mouse embryonic stem cells (ESCs) in S/G 2 are more efficient at reprogramming somatic cells than ESCs at other stages of the cell…”
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Mutations in CDK5RAP2 cause Seckel syndrome by Yigit, Gökhan, Brown, Karen E., Kayserili, Hülya, Pohl, Esther, Caliebe, Almuth, Zahnleiter, Diana, Rosser, Elisabeth, Bögershausen, Nina, Uyguner, Zehra Oya, Altunoglu, Umut, Nürnberg, Gudrun, Nürnberg, Peter, Rauch, Anita, Li, Yun, Thiel, Christian Thomas, Wollnik, Bernd

“…Seckel syndrome is a heterogeneous, autosomal recessive disorder marked by prenatal proportionate short stature, severe microcephaly, intellectual disability,…”
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Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin by Brown, Karen E, Guest, Simon S, Smale, Stephen T, Hahm, Kyungmin, Merkenschlager, Matthias, Fisher, Amanda G

“…Ikaros proteins are required for normal T, B, and NK cell development and are postulated to activate lymphocyte-specific gene expression. Here we examined…”
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Dynamic assembly of silent chromatin during thymocyte maturation by Smale, Stephen T, Su, Ruey-Chyi, Brown, Karen E, Saaber, Sanam, Fisher, Amanda G, Merkenschlager, Matthias

“…Considerable knowledge has been gained from temporal analyses of molecular events culminating in gene activation, but technical hurdles have hindered…”
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CEP152 is a genome maintenance protein disrupted in Seckel syndrome by Kalay, Ersan, Wollnik, Bernd, Yigit, Gökhan, Aslan, Yakup, Brown, Karen E, Pohl, Esther, Bicknell, Louise S, Kayserili, Hülya, Li, Yun, Tüysüz, Beyhan, Nürnberg, Gudrun, Kiess, Wieland, Koegl, Manfred, Baessmann, Ingelore, Buruk, Kurtulus, Toraman, Bayram, Kayipmaz, Saadettin, Kul, Sibel, Ikbal, Mevlit, Turner, Daniel J, Taylor, Martin S, Aerts, Jan, Scott, Carol, Milstein, Karen, Dollfus, Helene, Wieczorek, Dagmar, Brunner, Han G, Hurles, Matthew, Jackson, Andrew P, Rauch, Anita, Nürnberg, Peter, Karagüzel, Ahmet

“…Functional impairment of DNA damage response pathways leads to increased genomic instability. Here we describe the centrosomal protein CEP152 as a new…”
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