Search Results - "Brown, Jonathan"

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure by Anand, Priti, Brown, Jonathan D., Lin, Charles Y., Qi, Jun, Zhang, Rongli, Artero, Pedro Calderon, Alaiti, M. Amer, Bullard, Jace, Alazem, Kareem, Margulies, Kenneth B., Cappola, Thomas P., Lemieux, Madeleine, Plutzky, Jorge, Bradner, James E., Haldar, Saptarsi M.

“…Heart failure (HF) is driven by the interplay between regulatory transcription factors and dynamic alterations in chromatin structure. Pathologic gene…”
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Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice by McKay, Paul F., Hu, Kai, Blakney, Anna K., Samnuan, Karnyart, Brown, Jonathan C., Penn, Rebecca, Zhou, Jie, Bouton, Clément R., Rogers, Paul, Polra, Krunal, Lin, Paulo J. C., Barbosa, Christopher, Tam, Ying K., Barclay, Wendy S., Shattock, Robin J.

“…The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine. Here, we present a…”
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Availability of Integrated Primary Care Services in Community Mental Health Care Settings by Brown, Jonathan D

“…Objective:This study examined the availability of primary care and wellness services in community mental health centers (CMHCs) and outpatient mental health…”
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NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis by Brown, Jonathan D., Lin, Charles Y., Duan, Qiong, Griffin, Gabriel, Federation, Alexander J., Paranal, Ronald M., Bair, Steven, Newton, Gail, Lichtman, Andrew H., Kung, Andrew L., Yang, Tianlun, Wang, Hong, Luscinskas, Francis W., Croce, Kevin J., Bradner, James E., Plutzky, Jorge

“…Proinflammatory stimuli elicit rapid transcriptional responses via transduced signals to master regulatory transcription factors. To explore the role of…”
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Cardiovascular Effects of Androgen Deprivation Therapy in Prostate Cancer: Contemporary Meta-Analyses by Hu, Jiun-Ruey, Duncan, Meredith S., Morgans, Alicia K., Brown, Jonathan D., Meijers, Wouter C., Freiberg, Matthew S., Salem, Joe-Elie, Beckman, Joshua A., Moslehi, Javid J.

“…Androgen deprivation therapy is a cornerstone of prostate cancer treatment. Pharmacological androgen deprivation includes gonadotropin-releasing hormone…”
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Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages by Zhu, Yanfang Peipei, Brown, Jonathan R, Sag, Duygu, Zhang, Lihua, Suttles, Jill

“…AMP-activated protein kinase (AMPK) is a conserved serine/threonine kinase with a critical function in the regulation of metabolic pathways in eukaryotic…”
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A recalibration of strong-line oxygen abundance diagnostics via the direct method and implications for the high-redshift universe by Brown, Jonathan S., Martini, Paul, Andrews, Brett H.

“…We use direct method oxygen abundances in combination with strong optical emission lines, stellar masses (M ⋆), and star formation rates (SFRs) to recalibrate…”
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Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets by BROWN, Jonathan D, PLUTZKY, Jorge

“…Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors involved in the transcriptional regulation of key metabolic…”
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Role of Psychiatric Hospitals in the Equitable Distribution of COVID-19 Vaccines by Brown, Jonathan D, Bell, Nadia

“…Objective:This study examined the feasibility of offering COVID-19 vaccinations to patients in inpatient psychiatric facilities (IPFs).Methods:Descriptive…”
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Ion Correlation Effects in Salt-Doped Block Copolymers by Brown, Jonathan R, Seo, Youngmi, Hall, Lisa M

“…We apply classical density functional theory to study how salt changes the microphase morphology of diblock copolymers. Polymers are freely jointed and one…”
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Firm Behavior Under Conditions of Final Offer Arbitration: An Empirical Analysis of Major League Baseball’s Salary Negotiation Structure by Brown, Jonathan R

“…This paper explores the use of final offer interest arbitration (FOA) in Major League Baseball (MLB) and whether arbitrated salaries differ meaningfully from…”
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Inactivation of SARS-CoV-2 in chlorinated swimming pool water by Brown, Jonathan C, Moshe, Maya, Blackwell, Alex, Barclay, Wendy S

“…•SARS-CoV-2 is susceptible to inactivation by chlorinated swimming pool water.•At least 3-log10 reduction in the SARS-CoV-2 infectious titre observed after…”
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The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets by Peacock, Thomas P., Goldhill, Daniel H., Zhou, Jie, Baillon, Laury, Frise, Rebecca, Swann, Olivia C., Kugathasan, Ruthiran, Penn, Rebecca, Brown, Jonathan C., Sanchez-David, Raul Y., Braga, Luca, Williamson, Maia Kavanagh, Hassard, Jack A., Staller, Ecco, Hanley, Brian, Osborn, Michael, Giacca, Mauro, Davidson, Andrew D., Matthews, David A., Barclay, Wendy S.

“…SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and the S2ʹ cleavage sites to mediate membrane fusion. SARS-CoV-2 has a…”
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Mechanisms of VEGF (Vascular Endothelial Growth Factor) Inhibitor–Associated Hypertension and Vascular Disease by Pandey, Arvind K, Singhi, Eric K, Arroyo, Juan Pablo, Ikizler, Talat Alp, Gould, Edward R, Brown, Jonathan, Beckman, Joshua A, Harrison, David G, Moslehi, Javid

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Role of Solvation on Diffusion of Ions in Diblock Copolymers: Understanding the Molecular Weight Effect through Modeling by Seo, Youngmi, Shen, Kuan-Hsuan, Brown, Jonathan R, Hall, Lisa M

“…Salt-doped diblock copolymers with microphase-separated domains of both an ion conductive and a mechanically strong polymer have been extensively studied due…”
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Differences in Services Offered by Certified Community Behavioral Health Clinics and Community Mental Health Centers by Wishon, Allison A., Brown, Jonathan D.

“…Objective:This study examined differences between certified community behavioral health clinics (CCBHCs) and community mental health centers (CMHCs) in the…”
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BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure by Duan, Qiming, McMahon, Sarah, Anand, Priti, Shah, Hirsh, Thomas, Sean, Salunga, Hazel T, Huang, Yu, Zhang, Rongli, Sahadevan, Aarathi, Lemieux, Madeleine E, Brown, Jonathan D, Srivastava, Deepak, Bradner, James E, McKinsey, Timothy A, Haldar, Saptarsi M

“…Despite current standard of care, the average 5-year mortality after an initial diagnosis of heart failure (HF) is about 40%, reflecting an urgent need for new…”
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Factors Associated with the Receipt of Follow-Up Care Among Medicare Beneficiaries Discharged from Inpatient Psychiatric Facilities by Brown, Jonathan D., Bell, Nadia

“…This study examined the extent to which facility characteristics, discharge practices, and the availability of outpatient mental health care are associated…”
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Population health and regional variations of disease burden in Japan, 1990–2015: a systematic subnational analysis for the Global Burden of Disease Study 2015 by Nomura, Shuhei, Sakamoto, Haruka, Glenn, Scott, Tsugawa, Yusuke, Abe, Sarah K, Rahman, Md M, Brown, Jonathan C, Ezoe, Satoshi, Fitzmaurice, Christina, Inokuchi, Tsuyoshi, Kassebaum, Nicholas J, Kawakami, Norito, Kita, Yosuke, Kondo, Naoki, Lim, Stephen S, Maruyama, Satoshi, Miyata, Hiroaki, Mooney, Meghan D, Naghavi, Mohsen, Onoda, Tomoko, Ota, Erika, Otake, Yuji, Roth, Gregory A, Saito, Eiko, Tabuchi, Takahiro, Takasaki, Yohsuke, Tanimura, Tadayuki, Uechi, Manami, Vos, Theo, Wang, Haidong, Inoue, Manami, Murray, Christopher J L, Shibuya, Kenji

“…Japan has entered the era of super-ageing and advanced health transition, which is increasingly putting pressure on the sustainability of its health system…”
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Correction to: Factors Associated with the Receipt of Follow-Up Care Among Medicare Beneficiaries Discharged from Inpatient Psychiatric Facilities by Brown, Jonathan D., Bell, Nadia

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