Search Results - "Brown, Jon"

Fencing in the swampland: quantum gravity constraints on large field inflation by Brown, Jon, Cottrell, William, Shiu, Gary, Soler, Pablo

“…A bstract In this note we show that models of natural inflation based on closed string axions are incompatible with the weak gravity conjecture (WGC)…”
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On axionic field ranges, loopholes and the weak gravity conjecture by Brown, Jon, Cottrell, William, Shiu, Gary, Soler, Pablo

“…A bstract In this short note we clarify some aspects of the impact that the Weak Gravity Conjecture has on models of (generalized) natural inflation. We…”
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EEG microstate complexity for aiding early diagnosis of Alzheimer’s disease by Tait, Luke, Tamagnini, Francesco, Stothart, George, Barvas, Edoardo, Monaldini, Chiara, Frusciante, Roberto, Volpini, Mirco, Guttmann, Susanna, Coulthard, Elizabeth, Brown, Jon T., Kazanina, Nina, Goodfellow, Marc

“…The dynamics of the resting brain exhibit transitions between a small number of discrete networks, each remaining stable for tens to hundreds of milliseconds…”
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Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide by Tamagnini, Francesco, Scullion, Sarah, Brown, Jon T., Randall, Andrew D.

“…ABSTRACT Accumulation of beta‐amyloid (Aβ) peptides in the human brain is a canonical pathological hallmark of Alzheimer's disease (AD). Recent work in…”
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Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid [beta] peptide by Tamagnini, Francesco, Scullion, Sarah, Brown, Jon T, Randall, Andrew D

“…Accumulation of beta-amyloid (A[beta]) peptides in the human brain is a canonical pathological hallmark of Alzheimer's disease (AD). Recent work in…”
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Network substrates of cognitive impairment in Alzheimer’s Disease by Tait, Luke, Stothart, George, Coulthard, Elizabeth, Brown, Jon T., Kazanina, Nina, Goodfellow, Marc

“…•Cognitive impairment scores correlate with small-worldness of networks in Alzheimer’s Disease.•Computational modelling is used to uncover mechanisms of…”
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The Impact of COVID-19 on Telemedicine Utilization Across Multiple Service Lines in the United States by Betancourt, Jose A., Rosenberg, Matthew A., Zevallos, Ashley, Brown, Jon R., Mileski, Michael

“…The impact of COVID-19 on the U.S. healthcare industry cannot be overstated. Telemedicine utilization increased overnight as all healthcare providers rushed to…”
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β3-Adrenergic receptor-dependent modulation of the medium afterhyperpolarization in rat hippocampal CA1 pyramidal neurons by Church, Timothy W, Brown, Jon T, Marrion, Neil V

“…Action potential firing in hippocampal pyramidal neurons is regulated by generation of an afterhyperpolarization (AHP). Three phases of AHP are recognized,…”
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Neurophysiological alterations in the nucleus reuniens of a mouse model of Alzheimer's disease by Walsh, Darren A., Brown, Jon T., Randall, Andrew D.

“…Recently, increased neuronal activity in nucleus reuniens (Re) has been linked to hyperexcitability within hippocampal-thalamo-cortical networks in the J20…”
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TauP301L disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability by Hole, Katriona L., Zhu, Bangfu, Huggon, Laura, Brown, Jon T., Mason, Jody M., Williams, Robert J.

“…Tauopathies are characterised by the pathological accumulation of misfolded tau. The emerging view is that toxic tau species drive synaptic dysfunction and…”
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Tau isoform-specific enhancement of L-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons by Stan, Georgiana F., Church, Timothy W., Randall, Ellie, Harvey, Jenna R. M., Brown, Jon T., Wilkinson, Kevin A., Hanley, Jonathan G., Marrion, Neil V.

“…Accumulation of tau is observed in dementia, with human tau displaying 6 isoforms grouped by whether they display either 3 or 4 C-terminal repeat domains (3R…”
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Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease by Manso, Yasmina, Holland, Philip R., Kitamura, Akihiro, Szymkowiak, Stefan, Duncombe, Jessica, Hennessy, Edel, Searcy, James L., Marangoni, Martina, Randall, Andrew D., Brown, Jon T., McColl, Barry W., Horsburgh, Karen

“…Chronic cerebral hypoperfusion is a key mechanism associated with white matter disruption in cerebral vascular disease and dementia. In a mouse model relevant…”
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Control of clustered action potential firing in a mathematical model of entorhinal cortex stellate cells by Tait, Luke, Wedgwood, Kyle, Tsaneva-Atanasova, Krasimira, Brown, Jon T., Goodfellow, Marc

“…•An SDE model of entorhinal cortex (EC) stellate cells is proposed.•Experimentally observed action potential clustering is investigated in the model.•Clusters…”
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Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease by Brown, Jon T, Chin, Jeannie, Leiser, Steven C, Pangalos, Menelas N, Randall, Andrew D

“…Abstract Transgenic mice that overproduce beta-amyloid (Aβ) peptides can exhibit central nervous system network hyperactivity. Patch clamp measurements from…”
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Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons by Brown, Jon T., Randall, Andrew D.

“…Persistent plastic changes to the intrinsic excitability of neurons have substantial implications for computational processing within the CNS. We have…”
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β 3 -Adrenergic receptor-dependent modulation of the medium afterhyperpolarization in rat hippocampal CA1 pyramidal neurons by Church, Timothy W, Brown, Jon T, Marrion, Neil V

“…Action potential firing in hippocampal pyramidal neurons is regulated by generation of an afterhyperpolarization (AHP). Three phases of AHP are recognized,…”
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Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein by Tamagnini, Francesco, Walsh, Darren A., Brown, Jon T., Bondulich, Marie K., Hanger, Diane P., Randall, Andrew D.

“…The accumulation of cleaved tau fragments in the brain is associated with several tauopathies. For this reason, we recently developed a transgenic mouse that…”
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Age-related changes to Na+ channel gating contribute to modified intrinsic neuronal excitability by Randall, Andrew D, Booth, Clair, Brown, Jon T

“…Abstract Cognitive decline occurs during normal aging and is likely to be reflected in the neurophysiological properties of neural circuits with key roles in…”
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Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease by Corbett, Brian F, Leiser, Steven C, Ling, Huai-Ping, Nagy, Reka, Breysse, Nathalie, Zhang, Xiaohong, Hazra, Anupam, Brown, Jon T, Randall, Andrew D, Wood, Andrew, Pangalos, Menelas N, Reinhart, Peter H, Chin, Jeannie

“…BACE1 is the rate-limiting enzyme that cleaves amyloid precursor protein (APP) to produce the amyloid β peptides that accumulate in Alzheimer's disease (AD)…”
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Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons by Telezhkin, Vsevolod, Schnell, Christian, Yarova, Polina, Yung, Sun, Cope, Emma, Hughes, Alis, Thompson, Belinda A, Sanders, Philip, Geater, Charlene, Hancock, Jane M, Joy, Shona, Badder, Luned, Connor-Robson, Natalie, Comella, Andrea, Straccia, Marco, Bombau, Georgina, Brown, Jon T, Canals, Josep M, Randall, Andrew D, Allen, Nicholas D, Kemp, Paul J

“…Although numerous protocols have been developed for differentiation of neurons from a variety of pluripotent stem cells, most have concentrated on being able…”
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