Search Results - "Brown, Janice A"

Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators by Boehm, Markus, Beaumont, Kevin, Jones, Rhys, Kalgutkar, Amit S., Zhang, Liying, Atkinson, Karen, Bai, Guoyun, Brown, Janice A., Eng, Heather, Goetz, Gilles H., Holder, Brian R., Khunte, Bhagyashree, Lazzaro, Sarah, Limberakis, Chris, Ryu, Sangwoo, Shapiro, Michael J., Tylaska, Laurie, Yan, Jiangli, Turner, Rushia, Leung, Siegfried S. F., Ramaseshan, Mahesh, Price, David A., Liras, Spiros, Jacobson, Matthew P., Earp, David J., Lokey, R. Scott, Mathiowetz, Alan M., Menhaji-Klotz, Elnaz

“…The chemokine receptor CXCR7 is an attractive target for a variety of diseases. While several small-molecule modulators of CXCR7 have been reported, peptidic…”
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Discovery and Preclinical Characterization of 6‑Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]‑1H‑indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy by Cameron, Kimberly O, Kung, Daniel W, Kalgutkar, Amit S, Kurumbail, Ravi G, Miller, Russell, Salatto, Christopher T, Ward, Jessica, Withka, Jane M, Bhattacharya, Samit K, Boehm, Markus, Borzilleri, Kris A, Brown, Janice A, Calabrese, Matthew, Caspers, Nicole L, Cokorinos, Emily, Conn, Edward L, Dowling, Matthew S, Edmonds, David J, Eng, Heather, Fernando, Dilinie P, Frisbie, Richard, Hepworth, David, Landro, James, Mao, Yuxia, Rajamohan, Francis, Reyes, Allan R, Rose, Colin R, Ryder, Tim, Shavnya, Andre, Smith, Aaron C, Tu, Meihua, Wolford, Angela C, Xiao, Jun

“…Adenosine monophosphate-activated protein kinase (AMPK) is a protein kinase involved in maintaining energy homeostasis within cells. On the basis of human…”
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Discovery and evaluation of non-basic small molecule modulators of the atypical chemokine receptor CXCR7 by Aspnes, Gary E., Menhaji-Klotz, Elnaz, Boehm, Markus, Londregan, Allyn T., Lee, Esther C.Y., Limberakis, Chris, Coffey, Steven B., Brown, Janice A., Jones, Rhys M., Hesp, Kevin D.

“…[Display omitted] The atypical chemokine receptor C–X–C chemokine receptor type 7 (CXCR7) is an attractive therapeutic target for a variety of cardiac and…”
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Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Ryder, Tim F, Calabrese, Matthew F, Walker, Gregory S, Cameron, Kimberly O, Reyes, Allan R, Borzilleri, Kris A, Delmore, Jake, Miller, Russell, Kurumbail, Ravi G, Ward, Jessica, Kung, Daniel W, Brown, Janice A, Edmonds, David J, Eng, Heather, Wolford, Angela C, Kalgutkar, Amit S

“…Studies on indole-3-carboxylic acid derivatives as direct activators of human adenosine monophosphate-activated protein kinase (AMPK) α1β1γ1 isoform have…”
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Determination of Unbound Partition Coefficient and in Vitro-in Vivo Extrapolation for SLC13A Transporter-Mediated Uptake by Riccardi, Keith, Li, Zhenhong, Brown, Janice A, Gorgoglione, Matthew F, Niosi, Mark, Gosset, James, Huard, Kim, Erion, Derek M, Di, Li

“…Unbound partition coefficient (Kpuu) is important to an understanding of the asymmetric free drug distribution of a compound between cells and medium in vitro,…”
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Discovery of a Novel Small-Molecule Modulator of C–X–C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis by Menhaji-Klotz, Elnaz, Hesp, Kevin D, Londregan, Allyn T, Kalgutkar, Amit S, Piotrowski, David W, Boehm, Markus, Song, Kun, Ryder, Tim, Beaumont, Kevin, Jones, Rhys M, Atkinson, Karen, Brown, Janice A, Litchfield, John, Xiao, Jun, Canterbury, Daniel P, Burford, Kristen, Thuma, Benjamin A, Limberakis, Chris, Jiao, Wenhua, Bagley, Scott W, Agarwal, Saket, Crowell, Danielle, Pazdziorko, Stephen, Ward, Jessica, Price, David A, Clerin, Valerie

“…C–X–C chemokine receptor type 7 (CXCR7) is involved in cardiac and immune pathophysiology. We report the discovery of a novel 1,4-diazepine CXCR7 modulator,…”
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Discovery of Diphenylacetamides as CXCR7 Inhibitors with Novel β-Arrestin Antagonist Activity by Menhaji-Klotz, Elnaz, Ward, Jessica, Brown, Janice A., Loria, Paula M., Tan, Carina, Hesp, Kevin D., Riccardi, Keith A., Litchfield, John, Boehm, Markus

“…The atypical chemokine receptor CXCR7 has been studied in various disease settings including immunological diseases and heart disease. Efforts to elucidate the…”
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Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1) by Filipski, Kevin J, Sammons, Matthew F, Bhattacharya, Samit K, Panteleev, Jane, Brown, Janice A, Loria, Paula M, Boehm, Markus, Smith, Aaron C, Shavnya, Andre, Conn, Edward L, Song, Kun, Weng, Yan, Facemire, Carie, Jüppner, Harald, Clerin, Valerie

“…Sodium-phosphate cotransporter 2a, or NaPi2a (SLC34A1), is a solute-carrier (SLC) transporter located in the kidney proximal tubule that reabsorbs…”
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Zoniporide: a potent and highly selective inhibitor of human Na +/H + exchanger-1 by Marala, Ravi B, Brown, Janice A, Kong, Jimmy X, Tracey, W.Ross, Knight, Delvin R, Wester, Ronald T, Sun, Dexue, Kennedy, Scott P, Hamanaka, Ernest S, Ruggeri, Roger B, Hill, Roger J

“…We evaluated the in vitro pharmacological profile of a novel, potent and highly selective Na +/H + exchanger-1 (NHE-1) inhibitor,…”
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N-Benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors by Atkinson, Karen A., Beretta, Elena E., Brown, Janice A., Castrodad, Mayda, Chen, Yue, Cosgrove, Judith M., Du, Ping, Litchfield, John, Makowski, Michael, Martin, Kelly, McLellan, Thomas J., Neagu, Constantin, Perry, David A., Piotrowski, David W., Steppan, Claire M., Trilles, Richard

“…A potent, small molecule inhibitor with a favorable pharmacokinetic profile to allow for sustained SCD inhibition in vivo was identified. Biological evaluation…”
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Design, synthesis, and pharmacology of fluorescently labeled analogs of serotonin: application to screening of the 5-HT2C receptor by Cornelius, Peter, Lee, Eunsun, Lin, Wen, Wang, Ruduan, Werner, Wendy, Brown, Janice A, Stuhmeier, Frank, Boyd, James G, McClure, Kim

“…Novel fluorescent derivatives of serotonin have been synthesized and used as tracers for the development of a 5-HT2C fluorescence polarization assay. Serotonin…”
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Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity by Liu, Kevin K.-C., Lefker, Bruce A., Dombroski, Mark A., Chiang, Phoebe, Cornelius, Peter, Patterson, Terrell A., Zeng, Yuan, Santucci, Stephanie, Tomlinson, Elizabeth, Gibbons, Colleen P., Marala, Ravi, Brown, Janice A., Kong, Jimmy X., Lee, Eunsun, Werner, Wendy, Wenzel, Zane, Giragossian, Craig, Chen, Hou, Coffey, Steven B.

“…Brain-penetrable proline amides were developed as 5HT2c agonists with more than 1000-fold binding selectivity against 5HT2b receptor. After medicinal chemistry…”
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Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors by Brown, Janice A., Marala, Ravi B.

“…Introduction: Poly(ADP-ribose) polymerase (PARP) plays a pivotal role in the repair of DNA strand breaks. However, excessive activation of PARP causes a rapid…”
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Discovery of zoniporide: A potent and selective sodium–hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility by Guzman-Perez, Angel, Wester, Ronald T., Allen, Mary C., Brown, Janice A., Buchholz, Allan R., Cook, Ewell R., Day, Wesley W., Hamanaka, Ernest S., Kennedy, Scott P., Knight, Delvin R., Kowalczyk, Paul J., Marala, Ravi B., Mularski, Christian J., Novomisle, William A., Ruggeri, Roger B., Tracey, W.Ross, Hill, Roger J.

“…Zoniporide (CP-597,396) is a potent and selective inhibitor of NHE-1, which exhibits high aqueous solubility and acceptable pharmacokinetics for intravenous…”
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Acyl Glucuronide Metabolites of 6‑Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]‑1H‑indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Ryder, Tim F., Calabrese, Matthew F., Walker, Gregory S., Cameron, Kimberly O., Reyes, Allan R., Borzilleri, Kris A., Delmore, Jake, Miller, Russell, Kurumbail, Ravi G., Ward, Jessica, Kung, Daniel W., Brown, Janice A., Edmonds, David J., Eng, Heather, Wolford, Angela C., Kalgutkar, Amit S.

“…Studies on indole-3-carboxylic acid derivatives as direct activators of human adenosine monophosphate-activated protein kinase (AMPK) α1β1γ1 isoform have…”
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Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Edmonds, David J, Kung, Daniel W, Kalgutkar, Amit S, Filipski, Kevin J, Ebner, David C, Cabral, Shawn, Smith, Aaron C, Aspnes, Gary E, Bhattacharya, Samit K, Borzilleri, Kris A, Brown, Janice A, Calabrese, Matthew F, Caspers, Nicole L, Cokorinos, Emily C, Conn, Edward L, Dowling, Matthew S, Eng, Heather, Feng, Bo, Fernando, Dilinie P, Genung, Nathan E, Herr, Michael, Kurumbail, Ravi G, Lavergne, Sophie Y, Lee, Esther C.-Y, Li, Qifang, Mathialagan, Sumathy, Miller, Russell A, Panteleev, Jane, Polivkova, Jana, Rajamohan, Francis, Reyes, Allan R, Salatto, Christopher T, Shavnya, Andre, Thuma, Benjamin A, Tu, Meihua, Ward, Jessica, Withka, Jane M, Xiao, Jun, Cameron, Kimberly O

“…Optimization of the pharmacokinetic (PK) properties of a series of activators of adenosine monophosphate-activated protein kinase (AMPK) is described…”
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Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H -indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy by Cameron, Kimberly O., Kung, Daniel W., Kalgutkar, Amit S., Kurumbail, Ravi G., Miller, Russell, Salatto, Christopher T., Ward, Jessica, Withka, Jane M., Bhattacharya, Samit K., Boehm, Markus, Borzilleri, Kris A., Brown, Janice A., Calabrese, Matthew, Caspers, Nicole L., Cokorinos, Emily, Conn, Edward L., Dowling, Matthew S., Edmonds, David J., Eng, Heather, Fernando, Dilinie P., Frisbie, Richard, Hepworth, David, Landro, James, Mao, Yuxia, Rajamohan, Francis, Reyes, Allan R., Rose, Colin R., Ryder, Tim, Shavnya, Andre, Smith, Aaron C., Tu, Meihua, Wolford, Angela C., Xiao, Jun

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Corrigendum to “Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors” [J. Pharm. Tox. Meth. 47 (2002) 137–141] by Brown, Janice A., Marala, Ravi B.

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Prevention of transmitted infections in a pet therapy program: An exemplar by Hardin, Pam, ME, BS, RPP, Brown, Janice, MA, CIC, Wright, Mary Ellen, PhD, APRN, CPNP

“…Highlights • Guidelines have been recently published by the Society for Healthcare Epidemiology of America on the safe oversite and management of animals in…”
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Sedimentation properties of mammalian-cell DNA: evidence that non-specific molecular aggregation does not occur during cell lysis by Belli, J A, Cooper, S, Brown, J A

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