Search Results - "Brown, Jack D."

Research and Development of a Second-Generation Process for Oseltamivir Phosphate, Prodrug for a Neuraminidase Inhibitor by Harrington, Peter J, Brown, Jack D, Foderaro, Tommaso, Hughes, Robert C

“…A second-generation manufacturing process from a shikimic acid-derived epoxide to oseltamivir phosphate features a magnesium chloride−amine complex-catalyzed…”
Get full text

Tamiflu: The Supply Problem by Farina, Vittorio, Brown, Jack D.

“…Taming of the flu: Shikimic and quinic acids are the established starting materials for Tamiflu, a viral neuraminidase inhibitor that is considered by many as…”
Get full text

Facile and Scalable Methodology for the Pyrrolo[2,1‑f][1,2,4]triazine of Remdesivir by Roy, Sarabindu, Yadaw, Ajay, Roy, Subho, Sirasani, Gopal, Gangu, Aravind, Brown, Jack D, Armstrong, Joseph D, Stringham, Rodger W, Gupton, B. Frank, Senanayake, Chris H, Snead, David R

“…Pyrrolo­[2,1-f]­[1,2,4]­triazine (1) is an important regulatory starting material in the production of the antiviral drug remdesivir. Compound 1 was produced…”
Get full text

Development of a Scalable, Chromatography-Free Synthesis of t‑Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3‑Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation by Sieber, Joshua D, Rodriguez, Sonia, Frutos, Rogelio, Buono, Frederic, Zhang, Yongda, Li, Ning, Qu, Bo, Premasiri, Ajith, Li, Zhibin, Han, Zhengxu S, Xu, Yibo, Byrne, Denis, Haddad, Nizar, Lorenz, Jon, Grinberg, Nelu, Kurouski, Dmitry, Lee, Heewon, Narayanan, Bikshandarkoil, Nummy, Laurence, Mulder, Jason, Brown, Jack D, Granger, Alice, Gao, Joe, Krawiec, Mariusz, Williams, Zeena, Pennino, Scott, Song, Jinhua J, Hossain, Azad, Yee, Nathan K, Busacca, Carl, Roschangar, Frank, Xin, Yanchao, Mao, Zhantong, Zhang, Xinzhu, Hong, Yaping, Senanayake, Chris H

“…A chromatography-free, asymmetric synthesis of the C2-symmetric P-chiral diphosphine t-Bu-SMS-Phos was developed using a chiral auxiliary-based approach in…”
Get full text

Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF 3 -Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation by Sieber, Joshua D, Rodriguez, Sonia, Frutos, Rogelio, Buono, Frederic, Zhang, Yongda, Li, Ning, Qu, Bo, Premasiri, Ajith, Li, Zhibin, Han, Zhengxu S, Xu, Yibo, Byrne, Denis, Haddad, Nizar, Lorenz, Jon, Grinberg, Nelu, Kurouski, Dmitry, Lee, Heewon, Narayanan, Bikshandarkoil, Nummy, Laurence, Mulder, Jason, Brown, Jack D, Granger, Alice, Gao, Joe, Krawiec, Mariusz, Williams, Zeena, Pennino, Scott, Song, Jinhua J, Hossain, Azad, Yee, Nathan K, Busacca, Carl, Roschangar, Frank, Xin, Yanchao, Mao, Zhantong, Zhang, Xinzhu, Hong, Yaping, Senanayake, Chris H

“…A chromatography-free, asymmetric synthesis of the C2-symmetric P-chiral diphosphine t-Bu-SMS-Phos was developed using a chiral auxiliary-based approach in…”
Get full text

A highly stereocontrolled, four-step synthesis of (.+-.)-lasubine II by Brown, Jack D, Foley, Michael A, Comins, Daniel L

Get full text

Ortho metalation directed by .alpha.-amino alkoxides by Comins, Daniel L, Brown, Jack D

Get full text

The first nonenzymic stereospecific intramolecular reduction by an NADH-mimic containing a covalently bound carbonyl moiety by Meyers, A. I, Brown, Jack D

Get full text

Directed lithiation of tertiary .beta.-amino benzamides by Comins, Daniel L, Brown, Jack D

Get full text

Development of a Safer Continuous Flow Process for B2(OH)4‑Mediated Chemoselective Reduction of Nitroarenes to Anilines by Revu, Omkar, Vasilev, Maksim, Gajula, Praveen, Kalikinidi, Nageswara Rao, Gadi, Madhusudhan Reddy, Zhao, Huiping, Gamage, Shanika M. P., Hibbert, Graham, Ravikumar, Ongolu, Gummidi, Lalitha, Nasipireddy, Venkatarathnam, Vinodini, Arun, Bietsch, Jonathan, Wang, Zhirui, Brown, Jack D., Sirasani, Gopal, Armstrong, Joseph D., Gangu, Aravind S., Qu, Bo, Senanayake, Chris H.

“…Tetrahydroxydiboron [B2(OH)4] is a chemoselective reducing reagent for nitro reductions in the presence of other labile functional groups. However, there are…”
Get full text

Development of a Safer Continuous Flow Process for B 2 (OH) 4 -Mediated Chemoselective Reduction of Nitroarenes to Anilines by Revu, Omkar, Vasilev, Maksim, Gajula, Praveen, Kalikinidi, Nageswara Rao, Gadi, Madhusudhan Reddy, Zhao, Huiping, Gamage, Shanika M. P., Hibbert, Graham, Ravikumar, Ongolu, Gummidi, Lalitha, Nasipireddy, Venkatarathnam, Vinodini, Arun, Bietsch, Jonathan, Wang, Zhirui, Brown, Jack D., Sirasani, Gopal, Armstrong, Joseph D., Gangu, Aravind S., Qu, Bo, Senanayake, Chris H.

Get full text

Ortho substitution of m-anisaldehyde via .alpha.-amino alkoxide directed lithiation by Comins, Daniel L, Brown, Jack D

Get full text

Tamiflu: Das Versorgungsproblem by Farina, Vittorio, Brown, Jack D.

“…Die Zähmung der Grippe? Shikimi‐ und Chinasäure sind die üblichen Ausgangsverbindungen für Tamiflu (siehe Schema), einen viralen Neuraminidase‐Inhibitor für…”
Get full text

Tamiflu: Das Versorgungsproblem by Farina, Vittorio, Brown, Jack D.

Get full text