Search Results - "Brown, J.P."

Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels by Brown, Alistair J.P, Brown, Gordon D, Netea, Mihai G, Gow, Neil A.R

“…Highlights • Metabolic adaptation impacts upon Candida albicans pathogenicity at multiple levels. • Carbon sources influence virulence factor expression and…”
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Denosumab compared with risedronate in postmenopausal women suboptimally adherent to alendronate therapy: Efficacy and safety results from a randomized open-label study by Roux, C, Hofbauer, L.C, Ho, P.R, Wark, J.D, Zillikens, M.C, Fahrleitner-Pammer, A, Hawkins, F, Micaelo, M, Minisola, S, Papaioannou, N, Stone, M, Ferreira, I, Siddhanti, S, Wagman, R.B, Brown, J.P

“…Abstract Denosumab has been shown to reduce new vertebral, nonvertebral, and hip fractures in postmenopausal women with osteoporosis. In subjects who were…”
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A Multifunctional Mannosyltransferase Family in Candida albicans Determines Cell Wall Mannan Structure and Host-Fungus Interactions by Mora-Montes, Héctor M., Bates, Steven, Netea, Mihai G., Castillo, Luis, Brand, Alexandra, Buurman, Ed T., Díaz-Jiménez, Diana F., Jan Kullberg, Bart, Brown, Alistair J.P., Odds, Frank C., Gow, Neil A.R.

“…The cell wall proteins of fungi are modified by N- and O-linked mannosylation and phosphomannosylation, resulting in changes to the physical and immunological…”
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Infection-related gene expression in Candida albicans by Brown, Alistair J.P, Odds, Frank C, Gow, Neil A.R

“…Research into the major fungal pathogen, Candida albicans has firmly entered the post-genomics era. The current challenge is to apply these technologies to the…”
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Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans by Nicholls, Susan, MacCallum, Donna M., Kaffarnik, Florian A.R., Selway, Laura, Peck, Scott C., Brown, Alistair J.P.

“…The evolutionarily conserved heat shock transcription factor Hsf1 plays a central role in thermal adaptation in the major fungal pathogen of humans, Candida…”
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Nitric oxide and nitrosative stress tolerance in yeast by Tillmann, Anna, Gow, Neil A R, Brown, Alistair J P

“…The opportunistic human fungal pathogen Candida albicans encounters diverse environmental stresses when it is in contact with its host. When colonizing and…”
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5613022 SOCIETAL BURDEN OF SICKLE CELL DISEASE IN THE UK: EMPIRICAL ESTIMATES OF PRODUCTIVITY LOSS AND LOSS OF FUTURE INCOME USING REAL‐WORLD EVIDENCE by Besser, M., Jarvis, S., Hamlyn, M., Brown, J.P., Barcelos, G., Beaubrun, A., Binns, M., Rice, C.T.

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Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans by Tripathi, Gyanendra, Wiltshire, Carolyn, Macaskill, Susan, Tournu, Helene, Budge, Susan, Brown, Alistair J.P.

“…Candida albicans is a major fungal pathogen of humans. It regulates its morphology in response to various environmental signals, but many of these signals are…”
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In-host microevolution of Aspergillus fumigatus: A phenotypic and genotypic analysis by Ballard, Eloise, Melchers, Willem J.G., Zoll, Jan, Brown, Alistair J.P., Verweij, Paul E., Warris, Adilia

“…•Description of in-host adaptation of A. fumigatus promoting fungal persistence.•Significant in-host microevolution was identified in 13 consecutive A…”
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Denosumab improves density and strength parameters as measured by QCT of the radius in postmenopausal women with low bone mineral density by Genant, H.K, Engelke, K, Hanley, D.A, Brown, J.P, Omizo, M, Bone, H.G, Kivitz, A.J, Fuerst, T, Wang, H, Austin, M, Libanati, C

“…Abstract Background Bone strength is determined by both cortical and trabecular bone compartments and can be evaluated radiologically through measurement of…”
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Clinical course of infection and viral tissue tropism of hepatitis C virus–like nonprimate hepaciviruses in horses by Pfaender, Stephanie, Cavalleri, Jessika M.V., Walter, Stephanie, Doerrbecker, Juliane, Campana, Benedetta, Brown, Richard J.P., Burbelo, Peter D., Postel, Alexander, Hahn, Kerstin, Anggakusuma, Riebesehl, Nina, Baumgärtner, Wolfgang, Becher, Paul, Heim, Markus H., Pietschmann, Thomas, Feige, Karsten, Steinmann, Eike

“…Hepatitis C virus (HCV) has a very narrow species and tissue tropism and efficiently replicates only in humans and the chimpanzee. Recently, several studies…”
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Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after TH2-biased immunization by Ebenig, Aileen, Muraleedharan, Samada, Kazmierski, Julia, Todt, Daniel, Auste, Arne, Anzaghe, Martina, Gömer, André, Postmus, Dylan, Gogesch, Patricia, Niles, Marc, Plesker, Roland, Miskey, Csaba, Gellhorn Serra, Michelle, Breithaupt, Angele, Hörner, Cindy, Kruip, Carina, Ehmann, Rosina, Ivics, Zoltan, Waibler, Zoe, Pfaender, Stephanie, Wyler, Emanuel, Landthaler, Markus, Kupke, Alexandra, Nouailles, Geraldine, Goffinet, Christine, Brown, Richard J.P., Mühlebach, Michael D.

“…Vaccine-associated enhanced respiratory disease (VAERD) is a severe complication for some respiratory infections. To investigate the potential for VAERD…”
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Physiologically Relevant Alternative Carbon Sources Modulate Biofilm Formation, Cell Wall Architecture, and the Stress and Antifungal Resistance of Candida glabrata by Chew, Shu Yih, Ho, Kok Lian, Cheah, Yoke Kqueen, Sandai, Doblin, Brown, Alistair J P, Than, Leslie Thian Lung

“…Flexibility in carbon metabolism is pivotal for the survival and propagation of many human fungal pathogens within host niches. Indeed, flexible carbon…”
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Scalar nanostructure of the Candida albicans cell wall; a molecular, cellular and ultrastructural analysis and interpretation by Lenardon, Megan D., Sood, Prashant, Dorfmueller, Helge C., Brown, Alistair J.P., Gow, Neil A.R.

“…•In wild type C. albicans yeast cells grown in standard lab conditions:•Chitin microfibrils are interspersed throughout the inner layer of the cell wall.•Cell…”
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Five-year incident fracture risk assessed by quantitative multisite ultrasound: The Canadian Multicentre Osteoporosis study by Olszynski, W, Brown, J.P, Adachi, J, Hanley, D.A, Davison, K.S

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Differences in fungal immune recognition by monocytes and macrophages: N-mannan can be a shield or activator of immune recognition by Yadav, Bhawna, Mora-Montes, Héctor M., Wagener, Jeanette, Cunningham, Iain, West, Lara, Haynes, Ken, Brown, Alistair J.P., Gow, Neil A.R.

“…[Display omitted] •Cytokine response to N-mannan mutants was dependent on the immune cell type used.•N-mannan mutants stimulated less cytokines from monocytes…”
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The efficacy and tolerability of risedronate once a week for the treatment of postmenopausal osteoporosis by Brown, J P, Kendler, D L, McClung, M R, Emkey, R D, Adachi, J D, Bolognese, M A, Li, Z, Balske, A, Lindsay, R

“…This study evaluated the efficacy and tolerability of risedronate once a week (35 mg and 50 mg) compared with risedronate 5 mg once daily in women with…”
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Pathological Controversies in Breast Cancer: Classification of Ductal Carcinoma In Situ , Sentinel Lymph Nodes and Low Volume Metastatic Disease and Reporting of Neoadjuvant Chemotherapy Specimens by Provenzano, E, Brown, J.P, Pinder, S.E

“…Abstract The pathological classification of breast cancer is constantly being updated to reflect the advances in our clinical and biological understanding of…”
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Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants by Khera, Tanvi, Behrendt, Patrick, Bankwitz, Dorothea, Brown, Richard J.P., Todt, Daniel, Doepke, Mandy, Khan, Abdul Ghafoor, Schulze, Kai, Law, John, Logan, Michael, Hockman, Darren, Wong, Jason Alexander Ji-Xhin, Dold, Leona, Gonzalez-Motos, Victor, Spengler, Ulrich, Viejo-Borbolla, Abel, Ströh, Luisa J, Krey, Thomas, Tarr, Alexander W., Steinmann, Eike, Manns, Michael P., Klein, Florian, Guzman, Carlos A., Marcotrigiano, Joseph, Houghton, Michael, Pietschmann, Thomas

“…[Display omitted] •High resolution mapping of HVR1 and glycosylation sites’ impact on CD81 binding, antibody binding and virus neutralization.•Viral mutants…”
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Evidence for diminished skeletal load response in women who fracture early vs. those who fracture late in life by Hamilton, C, Beck, T.J, Khaled, A, Jamal, S.A, Adachi, J.D, Brown, J.P, Davison, K.S

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