Search Results - "Brown, Eric"

Antibacterial drug discovery in the resistance era by Brown, Eric D., Wright, Gerard D.

“…The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians, researchers, policymakers, politicians and the public at large. The…”
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Artificial Intelligence in Medical Practice: The Question to the Answer? by Miller, D. Douglas, Brown, Eric W.

“…Computer science advances and ultra-fast computing speeds find artificial intelligence (AI) broadly benefitting modern society—forecasting weather, recognizing…”
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New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance by Klobucar, Kristina, Brown, Eric D.

“…Because of the rise in antibiotic resistance and the dwindling pipeline of effective antibiotics, it is imperative to explore avenues that breathe new life…”
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Individual determinants of COVID-19 vaccine hesitancy by Gerretsen, Philip, Kim, Julia, Caravaggio, Fernando, Quilty, Lena, Sanches, Marcos, Wells, Samantha, Brown, Eric E, Agic, Branka, Pollock, Bruce G, Graff-Guerrero, Ariel

“…Novel coronavirus disease 2019 (COVID-19) vaccine hesitancy is a barrier to achieving herd immunity, and thus, a prominent public health concern. This study…”
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Gut microbiome lipid metabolism and its impact on host physiology by Brown, Eric M., Clardy, Jon, Xavier, Ramnik J.

“…Metabolites produced by commensal gut microbes impact host health through their recognition by the immune system and their influence on numerous metabolic…”
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Anticipating and Mitigating the Impact of the COVID-19 Pandemic on Alzheimer's Disease and Related Dementias by Brown, Eric E., Kumar, Sanjeev, Rajji, Tarek K., Pollock, Bruce G., Mulsant, Benoit H.

“…•The COVID-19 pandemic is causing global morbidity and mortality, straining health systems, and disrupting society, putting individuals with Alzheimer's…”
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Gut Microbiota Regulation of T Cells During Inflammation and Autoimmunity by Brown, Eric M, Kenny, Douglas J, Xavier, Ramnik J

“…The intestinal microbiota plays a crucial role in influencing the development of host immunity, and in turn the immune system also acts to regulate the…”
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Drug repurposing for antimicrobial discovery by Farha, Maya A., Brown, Eric D.

“…Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need to develop new antimicrobial drugs that are effective against…”
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The intestinal microbiome in early life: health and disease by Arrieta, Marie-Claire, Stiemsma, Leah T, Amenyogbe, Nelly, Brown, Eric M, Finlay, Brett

“…Human microbial colonization begins at birth and continues to develop and modulate in species abundance for about 3 years, until the microbiota becomes…”
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Fatty liver? Microbiome sphingolipids to the rescue by Brown, Eric M

“…In this issue of Cell Host & Microbe, Le et al. discover that addition of exogenous Bacteroides sphingolipids can reverse lipid accumulation in the liver in a…”
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Nanopore sequencing for fast determination of plasmids, phages, virulence markers, and antimicrobial resistance genes in Shiga toxin-producing Escherichia coli by González-Escalona, Narjol, Allard, Marc A, Brown, Eric W, Sharma, Shashi, Hoffmann, Maria

“…Whole genome sequencing can provide essential public health information. However, it is now known that widely used short-read methods have the potential to…”
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NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion by Wlodarska, Marta, Thaiss, Christoph A., Nowarski, Roni, Henao-Mejia, Jorge, Zhang, Jian-Ping, Brown, Eric M., Frankel, Gad, Levy, Maayan, Katz, Meirav N., Philbrick, William M., Elinav, Eran, Finlay, B. Brett, Flavell, Richard A.

“…Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial protective mechanism at the interface between the eukaryotic and…”
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The role of the immune system in governing host-microbe interactions in the intestine by Brown, Eric M, Sadarangani, Manish, Finlay, B Brett

“…The mammalian intestinal tract harbors a diverse community of trillions of microorganisms, which have co-evolved with the host immune system for millions of…”
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Food for thought: Opportunities to target carbon metabolism in antibacterial drug discovery by Tong, Madeline, Brown, Eric D.

“…Antimicrobial resistance is at an all‐time high and new drugs are required to overcome this crisis. Traditional approaches to drug discovery have failed to…”
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Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA -Mutant Ovarian Cancer Models by Kim, Hyoung, George, Erin, Ragland, Ryan, Rafail, Stavros, Zhang, Rugang, Krepler, Clemens, Morgan, Mark, Herlyn, Meenhard, Brown, Eric, Simpkins, Fiona

“…PARP inhibition (PARPi) has modest clinical activity in recurrent -mutant ( ) high-grade serous ovarian cancers (HGSOC). We hypothesized that PARPi increases…”
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A Deep Learning Approach to Antibiotic Discovery by Stokes, Jonathan M., Yang, Kevin, Swanson, Kyle, Jin, Wengong, Cubillos-Ruiz, Andres, Donghia, Nina M., MacNair, Craig R., French, Shawn, Carfrae, Lindsey A., Bloom-Ackermann, Zohar, Tran, Victoria M., Chiappino-Pepe, Anush, Badran, Ahmed H., Andrews, Ian W., Chory, Emma J., Church, George M., Brown, Eric D., Jaakkola, Tommi S., Barzilay, Regina, Collins, James J.

“…Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep…”
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Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control by Ackerman, Margaret E, Mikhailova, Anastassia, Brown, Eric P, Dowell, Karen G, Walker, Bruce D, Bailey-Kellogg, Chris, Suscovich, Todd J, Alter, Galit

“…Elite controllers (ECs) represent a unique model of a functional cure for HIV-1 infection as these individuals develop HIV-specific immunity able to…”
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Outer Membrane Disruption Overcomes Intrinsic, Acquired, and Spontaneous Antibiotic Resistance by MacNair, Craig R., Brown, Eric D.

“…The spread of antibiotic resistance is an urgent threat to global health that necessitates new therapeutics. Treatments for Gram-negative pathogens are…”
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Passivity and practical work extraction using Gaussian operations by Brown, Eric G, Friis, Nicolai, Huber, Marcus

“…Quantum states that can yield work in a cyclical Hamiltonian process form one of the primary resources in the context of quantum thermodynamics. Conversely,…”
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Strategies for target identification of antimicrobial natural products by Farha, Maya A, Brown, Eric D

“…Covering: 2000 to 2015Despite a pervasive decline in natural product research at many pharmaceutical companies over the last two decades, natural products have…”
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