Search Results - "Brown, Derek B."

Process Safety in the Pharmaceutical IndustryPart I: Thermal and Reaction Hazard Evaluation Processes and Techniques by Allian, Ayman D, Shah, Nisha P, Ferretti, Antonio C, Brown, Derek B, Kolis, Stanley P, Sperry, Jeffrey B

“…Process safety groups in the pharmaceutical industry are important components of active pharmaceutical ingredient (API) development through its life cycle from…”
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Synthesis and Explosion Hazards of 4‑Azido‑l‑phenylalanine by Richardson, Mark B, Brown, Derek B, Vasquez, Carlos A, Ziller, Joseph W, Johnston, Kevin M, Weiss, Gregory A

“…A reliable, scalable, cost-effective, and chromatography-free synthesis of 4-azido-l-phenylalanine beginning from l-phenylalanine is described. Investigations…”
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Thermal Hazards of Using Propargyl Alcohol with Strong Bases by Brown, Derek B, Allian, Ayman D, Chen, Ying

“…Thermal hazard screening of a reaction mixture that involves the use of propargyl alcohol as the reactant/solvent along with potassium hydroxide as catalyst…”
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Ipso Nitration of Aryl Boronic Acids Using Fuming Nitric Acid by Murray, James I, Silva Elipe, Maria V, Baucom, Kyle D, Brown, Derek B, Quasdorf, Kyle, Caille, Seb

“…The ipso nitration of aryl boronic acid derivatives has been developed using fuming nitric acid as the nitrating agent. This facile procedure provides…”
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Hazard Evaluation and Safety Considerations for Scale-Up of a Fuming Nitric Acid Mediated Nitration of Aryl Boronic Acids by Murray, James I, Brown, Derek B, Silva Elipe, Maria V, Caille, Seb

“…Our laboratory has recently reported the highly efficient and chemoselective ipso nitration of aryl boronic acids using fuming nitric acid as the nitrating…”
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Evolution of Iridium-Based Molecular Catalysts during Water Oxidation with Ceric Ammonium Nitrate by Grotjahn, Douglas B, Brown, Derek B, Martin, Jessica K, Marelius, David C, Abadjian, Marie-Caline, Tran, Hai N, Kalyuzhny, Gregory, Vecchio, Kenneth S, Specht, Zephen G, Cortes-Llamas, Sara A, Miranda-Soto, Valentin, van Niekerk, Christoffel, Moore, Curtis E, Rheingold, Arnold L

“…Organometallic iridium complexes have been reported as water oxidation catalysts (WOCs) in the presence of ceric ammonium nitrate (CAN). One challenge for all…”
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Continuous Process Improvement in the Manufacture of Carfilzomib, Part 2: An Improved Process for Synthesis of the Epoxyketone Warhead by Beaver, Matthew G, Shi, Xianqing, Riedel, Jan, Patel, Parth, Zeng, Alicia, Corbett, Michael T, Robinson, Jo Anna, Parsons, Andrew T, Cui, Sheng, Baucom, Kyle, Lovette, Michael A, Içten, Elçin, Brown, Derek B, Allian, Ayman, Flick, Tawnya G, Chen, Wendy, Yang, Ning, Walker, Shawn D

“…The development and kilogram-scale demonstration of an improved process for the synthesis of the epoxyketone warhead of carfilzomib is described. Critical to…”
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Safety Notables: Information from the Literature by Brown, Derek B, Ironside, Michael D, Shaw, Stephen M

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Pilot-Plant Preparation of an αvβ3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling by Clark, Jerry D, Anderson, D. Keith, Banaszak, David V, Brown, Derek B, Czyzewski, Ann M, Edeny, Albert D, Forouzi, Puneh S, Gallagher, Donald J, Iskos, V. H, Kleine, H. Peter, Knable, Carl M, Lantz, Melissa K, Lapack, Mark A, Moore, Christine M. V, Muellner, Frank W, Murphy, James B, Orihuela, Carlos A, Pietz, Mark A, Rogers, Thomas E, Ruminski, Peter G, Santhanam, Harish K, Schilke, Tobin C, Shah, Ajit S, Sheikh, Ahmad Y, Weisenburger, Gerald A, Wise, Bruce E

“…Studies directed toward the process research, development, and scale-up preparation of the potential αvβ3 integrin antagonist 1 are described. A convergent…”
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Access to substituted trifluoromethyl ketones using the versatile synthetic intermediate (E)-1,1-dimethyl-2-(1,1,1-trifluoropropan-2-ylidene)hydrazine by Judd, Ted C., Brown, Derek B.

“…[Display omitted] •Alkyl substituted trifluoromethyl ketones are synthesized in high yield.•Unique β-hydroxy trifluoromethyl ketones can be prepared.•First…”
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A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 3: Manganese-Catalyzed Asymmetric Epoxidation, Crystallization, and Filtration by Maloney, Andrew J., Içten, Elçin, Capellades, Gerard, Beaver, Matthew G., Zhu, Xiaoxiang, Graham, Lauren R., Brown, Derek B., Griffin, Daniel J., Sangodkar, Rahul, Allian, Ayman, Huggins, Seth, Hart, Roger, Rolandi, Pablo, Walker, Shawn D., Braatz, Richard D.

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Axial Chirality in the Sotorasib Drug Substance, Part 2: Leveraging a High-Temperature Thermal Racemization to Recycle the Classical Resolution Waste Stream by Beaver, Matthew G., Brown, Derek B., Campbell, Kiersten, Fang, Yuan-Qing, Ford, David D., Mardirossian, Narbe, Nagy, Kevin D., Rötheli, Andreas R., Sheeran, Jillian W., Telmesani, Reem, Parsons, Andrew T.

“…The development and kilogram-scale demonstration of a high-temperature continuous-flow racemization process to recycle the off-enantiomer of an atropisomeric…”
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A Continuous Process for Manufacturing Apremilast. Part I: Process Development and Intensification by Utilizing Flow Chemistry Principles by Hsieh, Hsiao-Wu, Cohen, Carolyn M., Griffin, Daniel J., Ananthoji, Padmini, Avci, Nadide Hazal, Brown, Derek B., Ericson, Ari, Fostinis, James D., Irfan, Muhammad, Langille, Neil, Lovette, Michael A., Murray, James I., Spada, Simone, Thiel, Oliver R., Aiello, Frankie, Daou, Joseph, Goudas-Salomon, Nicole, Pan, Ende, Sarkar, Nandini, Wimalasinghe, Rasangi, Wu, Zufan Steven, Zeng, Alicia, Beaver, Matthew G.

“…Herein, we report the development of an integrated continuous manufacturing (CM) process for the penultimate step in the synthesis of apremilast, the drug…”
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Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor by Zhang, Liang, Griffin, Daniel J., Beaver, Matthew G., Blue, Laura E., Borths, Christopher J., Brown, Derek B., Caille, Seb, Chen, Ying, Cherney, Alan H., Cochran, Brian M., Colyer, John T., Corbett, Michael T., Correll, Tiffany L., Crockett, Richard D., Dai, Xi-Jie, Dornan, Peter K., Farrell, Robert P., Hedley, Simon J., Hsieh, Hsiao-Wu, Huang, Liang, Huggins, Seth, Liu, Min, Lovette, Michael A., Quasdorf, Kyle, Reifman, Jonathan, Robinson, Jo Anna, Sangodkar, Rahul P., Sharma, Sonika, Kumar, Srividya Sharvan, Smith, Austin G., St-Pierre, Gabrielle, Tedrow, Jason S., Thiel, Oliver R., Truong, Jonathan V., Walker, Shawn D., Wei, Carolyn S., Wilsily, Ashraf, Xie, Yong, Yang, Ning, Parsons, Andrew T.

“…A commercial process to manufacture sotorasib (AMG 510), a first-in-class KRASG12C inhibitor, is described. Development efforts focused on rendering a…”
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Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRAS G12C Inhibitor by Zhang, Liang, Griffin, Daniel J., Beaver, Matthew G., Blue, Laura E., Borths, Christopher J., Brown, Derek B., Caille, Seb, Chen, Ying, Cherney, Alan H., Cochran, Brian M., Colyer, John T., Corbett, Michael T., Correll, Tiffany L., Crockett, Richard D., Dai, Xi-Jie, Dornan, Peter K., Farrell, Robert P., Hedley, Simon J., Hsieh, Hsiao-Wu, Huang, Liang, Huggins, Seth, Liu, Min, Lovette, Michael A., Quasdorf, Kyle, Powazinik, William, Reifman, Jonathan, Robinson, Jo Anna, Sangodkar, Rahul P., Sharma, Sonika, Kumar, Srividya Sharvan, Smith, Austin G., St-Pierre, Gabrielle, Tedrow, Jason S., Thiel, Oliver R., Truong, Jonathan V., Walker, Shawn D., Wei, Carolyn S., Wilsily, Ashraf, Xie, Yong, Yang, Ning, Parsons, Andrew T.

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Pilot-Plant Preparation of an α v β 3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling by Clark, Jerry D., Anderson, D. Keith, Banaszak, David V., Brown, Derek B., Czyzewski, Ann M., Edeny, Albert D., Forouzi, Puneh S., Gallagher, Donald J., Iskos, V. H., Kleine, H. Peter, Knable, Carl M., Lantz, Melissa K., Lapack, Mark A., Moore, Christine M. V., Muellner, Frank W., Murphy, James B., Orihuela, Carlos A., Pietz, Mark A., Rogers, Thomas E., Ruminski, Peter G., Santhanam, Harish K., Schilke, Tobin C., Shah, Ajit S., Sheikh, Ahmad Y., Weisenburger, Gerald A., Wise, Bruce E.

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