Search Results - "Brown, C. S."

High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance by Wambaugh, Morgan A, Shakya, Viplendra P S, Lewis, Adam J, Mulvey, Matthew A, Brown, Jessica C S

“…Antibiotic-resistant infections kill approximately 23,000 people and cost $20,000,000,000 each year in the United States alone despite the widespread use of…”
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Soil net nitrogen mineralisation across global grasslands by Risch, A. C., Zimmermann, S., Ochoa-Hueso, R., Schütz, M., Frey, B., Firn, J. L., Fay, P. A., Hagedorn, F., Borer, E. T., Seabloom, E. W., Harpole, W. S., Knops, J. M. H., McCulley, R. L., Broadbent, A. A. D., Stevens, C. J., Silveira, M. L., Adler, P. B., Báez, S., Biederman, L. A., Blair, J. M., Brown, C. S., Caldeira, M. C., Collins, S. L., Daleo, P., di Virgilio, A., Ebeling, A., Eisenhauer, N., Esch, E., Eskelinen, A., Hagenah, N., Hautier, Y., Kirkman, K. P., MacDougall, A. S., Moore, J. L., Power, S. A., Prober, S. M., Roscher, C., Sankaran, M., Siebert, J., Speziale, K. L., Tognetti, P. M., Virtanen, R., Yahdjian, L., Moser, B.

“…Soil nitrogen mineralisation (N min ), the conversion of organic into inorganic N, is important for productivity and nutrient cycling. The balance between…”
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Isoscape Models of the Southern Ocean: Predicting Spatial and Temporal Variability in Carbon and Nitrogen Isotope Compositions of Particulate Organic Matter by St John Glew, Katie, Espinasse, Boris, Hunt, Brian P. V., Pakhomov, Evgeny A., Bury, Sarah J., Pinkerton, Matt, Nodder, Scott D., Gutiérrez‐Rodríguez, Andres, Safi, Karl, Brown, Julie C. S., Graham, Laura, Dunbar, Robert B., Mucciarone, David A., Magozzi, Sarah, Somes, Chris, Trueman, Clive N.

“…Polar marine ecosystems are particularly vulnerable to the effects of climate change. Warming temperatures, freshening seawater, and disruption to sea‐ice…”
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Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012 by Bermingham, A, Chand, M A, Brown, C S, Aarons, E, Tong, C, Langrish, C, Hoschler, K, Brown, K, Galiano, M, Myers, R, Pebody, R G, Green, H K, Boddington, N L, Gopal, R, Price, N, Newsholme, W, Drosten, C, Fouchier, R A, Zambon, M

“…Coronaviruses have the potential to cause severe transmissible human disease, as demonstrated by the severe acute respiratory syndrome (SARS) outbreak of 2003…”
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Expression of CD11c and EMR2 on neutrophils: potential diagnostic biomarkers for sepsis and systemic inflammation by Lewis, S. M., Treacher, D. F., Edgeworth, J., Mahalingam, G., Brown, C. S, Mare, T. A, Stacey, M., Beale, R., Brown, K.A.

“…Summary There is a need for cellular biomarkers to differentiate patients with sepsis from those with the non‐infectious systemic inflammatory response…”
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Dynamics of toxigenic Clostridium perfringens colonisation in a cohort of prematurely born neonatal infants by Shaw, Alexander G, Cornwell, Emma, Sim, Kathleen, Thrower, Hannah, Scott, Hannah, Brown, Joseph C S, Dixon, Ronald A, Kroll, J Simon

“…Clostridium perfringens forms part of the human gut microbiota and has been associated with life-threatening necrotising enterocolitis (NEC) in premature…”
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Assessing the added value of group B Streptococcus maternal immunisation in preventing maternal infection and fetal harm: population surveillance study by Lamagni, T, Wloch, C, Broughton, K, Collin, SM, Chalker, V, Coelho, J, Ladhani, SN, Brown, CS, Shetty, N, Johnson, AP

“…Objective To assess the incidence of maternal group B Streptococcus (GBS) infection in England. Design Population surveillance augmented through data linkage…”
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Radiation exposure protection: small things matter by Buys, D G, Brown, S C

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Reduced expression of fukutin related protein in mice results in a model for fukutin related protein associated muscular dystrophies by Ackroyd, M. R., Skordis, L., Kaluarachchi, M., Godwin, J., Prior, S., Fidanboylu, M., Piercy, R. J., Muntoni, F., Brown, S. C.

“…Mutations in fukutin related protein (FKRP) are responsible for a common group of muscular dystrophies ranging from adult onset limb girdle muscular…”
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Disease severity in dominant Emery Dreifuss is increased by mutations in both emerin and desmin proteins by Muntoni, F., Bonne, G., Goldfarb, L. G., Mercuri, E., Piercy, R. J., Burke, M., Yaou, R. Ben, Richard, P., Récan, D., Shatunov, A., Sewry, C. A., Brown, S. C.

“…Individuals with the same genetic disorder often show remarkable differences in clinical severity, a finding generally attributed to the genetic background. We…”
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Radiation safety: time to act by Brown, S C

“…[...]interventional cardiac procedures represent the largest contribution of ionising radiation source after computerised tomography and nuclear medicine…”
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Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window? by Hildyard, J C W, Lacey, E, Booler, H, Hopkinson, M, Wells, D J, Brown, S C

“…LARGE is a glycosyltransferase involved in glycosylation of α-dystroglycan (α-DG). Absence of this protein in the LARGEmyd mouse results in α-DG…”
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Immunohistological intensity measurements as a tool to assess sarcolemma-associated protein expression by Arechavala-Gomeza, V., Kinali, M., Feng, L., Brown, S. C., Sewry, C., Morgan, J. E., Muntoni, F.

“…V. Arechavala‐Gomeza, M. Kinali, L. Feng, S. C. Brown, C. Sewry, J. E. Morgan and F. Muntoni (2010) Neuropathology and Applied Neurobiology36, 265–274…”
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Evolution of genome size across some cultivated Allium species by Ricroch, A, Yockteng, R, Brown, S C, Nadot, S

“…Allium L. (Alliaceae), a genus of major economic importance, exhibits a great diversity in various morphological characters and particularly in life form, with…”
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FKRP gene mutations cause congenital muscular dystrophy, mental retardation, and cerebellar cysts by TOPALOGLU, H, BROCKINGTON, M, YUVA, Y, TALIM, B, HALILOGLU, G, BLAKE, D, TORELLI, S, BROWN, S. C, MUNTONI, F

“…Congenital muscular dystrophies (CMD) are autosomal recessive disorders that present within the first 6 months of life with hypotonia and a dystrophic muscle…”
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Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling by Brown, Jessica C S, Madhani, Hiten D

“…In many human fungal pathogens, genes required for disease remain largely unannotated, limiting the impact of virulence gene discovery efforts. We tested the…”
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The United Kingdom public health response to an imported laboratory confirmed case of a novel coronavirus in September 2012 by Pebody, R G, Chand, M A, Thomas, H L, Green, H K, Boddington, N L, Carvalho, C, Brown, C S, Anderson, S R, Rooney, C, Crawley-Boevey, E, Irwin, D J, Aarons, E, Tong, C, Newsholme, W, Price, N, Langrish, C, Tucker, D, Zhao, H, Phin, N, Crofts, J, Bermingham, A, Gilgunn-Jones, E, Brown, K E, Evans, B, Catchpole, M, Watson, J M

“…On 22 September 2012, a novel coronavirus, very closely related to that from a fatal case in Saudi Arabia three months previously, was detected in a previously…”
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Mechanisms of Pulmonary Escape and Dissemination by Cryptococcus neoformans by Denham, Steven T, Brown, Jessica C S

“…is a common environmental saprophyte and human fungal pathogen that primarily causes disease in immunocompromised individuals. Similar to many environmentally…”
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Synergistic and antagonistic drug interactions in the treatment of systemic fungal infections by Wambaugh, Morgan A, Denham, Steven T, Ayala, Magali, Brammer, Brianna, Stonhill, Miekan A, Brown, Jessica Cs

“…Invasive fungal infections cause 1.6 million deaths annually, primarily in immunocompromised individuals. Mortality rates are as high as 90% due to limited…”
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Nuclear DNA content, base composition, heterochromatin and rDNA in Picea omorika and Picea abies by SILJAK-YAKOVLEV, S, CERBAH, M, COULAUD, J, STOIAN, V, BROWN, S. C, ZOLDOS, V, JELENIC, S, PAPES, D

“…Two closely related spruces, Picea abies and Picea omorika, a Balkan paleoendemic species, often share habitats, yet never hybridize in nature. The present…”
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