Search Results - "Brown, C. Randell"

Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine by Hong-Brown, Ly Q, Brown, C Randell, Kazi, Abid A, Navaratnarajah, Maithili, Lang, Charles H

“…Leucine (Leu) and insulin both stimulate muscle protein synthesis, albeit at least in part via separate signaling pathways. While alcohol (EtOH) suppresses…”
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Alcohol-Induced Modulation of Rictor and mTORC2 Activity in C2C12 Myoblasts by Hong-Brown, Ly Q., Brown, C. Randell, Navaratnarajah, Maithili, Huber, Danuta S., Lang, Charles H.

“…Background:  The mammalian target of rapamycin (mTOR) kinase controls cell growth, proliferation, and metabolism through 2 distinct multiprotein complexes,…”
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The Vacuole Import and Degradation Pathway Utilizes Early Steps of Endocytosis and Actin Polymerization to Deliver Cargo Proteins to the Vacuole for Degradation by Brown, C. Randell, Dunton, Danielle, Chiang, Hui-Ling

“…When glucose is added to yeast cells that are starved for 3 days, fructose-1,6-bisphosphatase (FBPase) and malate dehydrogenase 2 are degraded in the vacuole…”
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The Vacuolar Import and Degradation Pathway Merges with the Endocytic Pathway to Deliver Fructose-1,6-bisphosphatase to the Vacuole for Degradation by Brown, C. Randell, Wolfe, Allison B., Cui, Dongying, Chiang, Hui-Ling

“…The gluconeogenic enzyme fructose-1,6-bisphosphatase (FBPase) is degraded in the vacuole when glucose is added to glucose-starved cells. Before it is delivered…”
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Alcohol Regulates Eukaryotic Elongation Factor 2 Phosphorylation via an AMP-activated Protein Kinase-dependent Mechanism in C2C12 Skeletal Myocytes by Hong-Brown, Ly Q., Brown, C.Randell, Huber, Danuta S., Lang, Charles H.

“…Ethanol decreases protein synthesis in cells, although the underlying regulatory mechanisms of this process are not fully established. In the present study…”
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Degradation of the Gluconeogenic Enzymes Fructose-1,6-bisphosphatase and Malate Dehydrogenase Is Mediated by Distinct Proteolytic Pathways and Signaling Events by Hung, Guo-Chiuan, Brown, C Randell, Wolfe, Allison B, Liu, Jingjing, Chiang, Hui-Ling

“…The key gluconeogenic enzyme fructose-1,6-bisphosphatase (FBPase) is subjected to catabolite inactivation and degradation when glucose-starved cells are…”
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Alcohol and Indinavir Adversely Affect Protein Synthesis and Phosphorylation of MAPK and mTOR Signaling Pathways in C2C12 Myocytes by Hong-Brown, Ly Q., Brown, C. Randell, Huber, Danuta S., Lang, Charles H.

“…Background: Alcohol and the antiretroviral drug indinavir (Ind) decrease protein synthesis in skeletal muscle under in vivo and in vitro conditions. The goal…”
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FoxO1‐AMPK‐ULK1 Regulates Ethanol‐Induced Autophagy in Muscle by Enhanced ATG14 Association with the BECN1‐PIK3C3 Complex by Hong‐Brown, Ly Q., Brown, C. Randell, Navaratnarajah, Maithili, Lang, Charles H.

“…Background Excessive alcohol (EtOH) consumption causes an imbalance in protein metabolism. EtOH impairs protein synthesis in C2C12 myoblasts via a…”
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Adamts1 Mediates Ethanol-Induced Alterations in Collagen and Elastin via a FoxO1-Sestrin3-AMPK Signaling Cascade in Myocytes by Hong-Brown, Ly Q, Brown, CRandell, Navaratnarajah, Maithili, Lang, Charles H

“…A variety of stressors including alcohol (EtOH) are known to induce collagen production and fibrotic diseases. Matrix metalloproteinases (MMP) play an…”
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The Type 1 Phosphatase Reg1p-Glc7p Is Required for the Glucose-induced Degradation of Fructose-1,6-bisphosphatase in the Vacuole by Cui, Dong-Ying, Brown, C. Randell, Chiang, Hui-Ling

“…Protein phosphatases play an important role in vesicular trafficking and membrane fusion processes. The type 1 phosphatase Glc7p and its regulatory subunit…”
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The Heat Shock Protein Ssa2p Is Required for Import of Fructose-1,6-Bisphosphatase into Vid Vesicles by Brown, C. Randell, McCann, Jameson A., Chiang, Hui-Ling

“…Fructose-1,6-bisphosphatase (FBPase) is targeted to the vacuole for degradation when Saccharomyces cerevisiae are shifted from low to high glucose. Before…”
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Vid22p, a novel plasma membrane protein, is required for the fructose-1,6-bisphosphatase degradation pathway by Brown, C Randell, McCann, Jameson A, Hung, Graham Guo-Chiuan, Elco, Christopher P, Chiang, Hui-Ling

“…Fructose-1,6-bisphosphatase (FBPase), an important enzyme in the gluconeogenic pathway in Saccharomyces cerevisiae, is expressed when cells are grown in media…”
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Degradation of the Gluconeogenic Enzyme Fructose-1,6-Bisphosphatase is Dependent on the Vacuolar ATPase by Liu, Jingjing, Brown, C. Randell, Chiang, Hui-Ling

“…The key gluconeogenic enzyme fructose-1,6-bisphosphatase (FBPase) is induced during glucose starvation. After the addition of glucose, inactivated FBPase is…”
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The Vid Vesicle to Vacuole Trafficking Event Requires Components of the SNARE Membrane Fusion Machinery by Brown, C.Randell, Liu, Jingjing, Hung, Guo-Chiuan, Carter, Donald, Cui, Dongying, Chiang, Hui-Ling

“…The key gluconeogenic enzyme fructose-1,6-bisphosphatase (FBPase) is targeted to Vid vesicles when glucose-starved cells are replenished with glucose. Vid…”
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Activation of AMPK/TSC2/PLD by Alcohol Regulates mTORC1 and mTORC2 Assembly in C2C12 Myocytes by Hong-Brown, Ly Q., Brown, C. Randell, Navaratnarajah, Maithili, Lang, Charles H.

“…Background Ethanol (EtOH) decreases muscle protein synthesis, and this is associated with reduced mammalian target of rapamycin complex (mTORC)1 and increased…”
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The TOR Complex 1 Is Distributed in Endosomes and in Retrograde Vesicles That Form from the Vacuole Membrane and Plays an Important Role in the Vacuole Import and Degradation Pathway by Brown, C. Randell, Hung, Guo-Chiuan, Dunton, Danielle, Chiang, Hui-Ling

“…The key gluconeogenic enzyme fructose-1,6-bisphosphatase (FBPase) is induced when Saccharomyces cerevisiae are starved of glucose. However, when glucose is…”
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Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction by Hong-Brown, Ly Q., Brown, C. Randell, Kazi, Abid A., Huber, Danuta S., Pruznak, Anne M., Lang, Charles H.

“…The mTORC1 protein kinase complex consists of mTOR, raptor, mLST8/GβL and PRAS40. Previously, we reported that mTOR plays an important role in regulating…”
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The Constitutive and Stress Inducible Forms of hsp 70 Exhibit Functional Similarities and Interact with One Another in an ATP-Dependent Fashion by Brown, C. Randell, Martin, Robert L., Hansen, William J., Beckmann, Richard P., Welch, William J.

“…Mammalian cells constitutively express a cytosolic and nuclear form of heat shock protein (hsp) 70, referred to here as hsp 73. In response to heat shock or…”
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Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase by Hong-Brown, Ly Q., Brown, C. Randell, Huber, Danuta S., Lang, Charles H.

“…HIV anti‐retroviral drugs decrease protein synthesis, although the underlying regulatory mechanisms of this process are not fully established. Therefore, we…”
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A selective autophagy pathway that degrades gluconeogenic enzymes during catabolite inactivation by Brown, C.R., Chiang, Hui-Ling

“…In Saccharomyces cerevisiae, glucose starvation induces key gluconeogenic enzymes such as fructose-1,6-bisphosphatase (FBPase), malate dehydrogenase (MDH2) and…”
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