Search Results - "Brown, Brian D"

Expansion and Activation of CD103+ Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition by Salmon, Hélène, Idoyaga, Juliana, Rahman, Adeeb, Leboeuf, Marylène, Remark, Romain, Jordan, Stefan, Casanova-Acebes, Maria, Khudoynazarova, Makhzuna, Agudo, Judith, Tung, Navpreet, Chakarov, Svetoslav, Rivera, Christina, Hogstad, Brandon, Bosenberg, Marcus, Hashimoto, Daigo, Gnjatic, Sacha, Bhardwaj, Nina, Palucka, Anna Karolina, Brown, Brian D., Brody, Joshua, Ginhoux, Florent, Merad, Miriam

“…Large numbers of melanoma lesions develop resistance to targeted inhibition of mutant BRAF or fail to respond to checkpoint blockade. We explored whether…”
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Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications by Brown, Brian D, Naldini, Luigi

“…Constructs containing artificial microRNA target sites have the potential to improve a range of therapeutic strategies that are based on gene delivery or…”
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Studying the mononuclear phagocyte system in the molecular age by Merad, Miriam, Chow, Andrew, Brown, Brian D

“…Key Points The study of animals with global knockouts of genes encoding various cytokines, cytokine receptors and transcription factors has been crucial for…”
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Cancer vaccines: the next immunotherapy frontier by Lin, Matthew J, Svensson-Arvelund, Judit, Lubitz, Gabrielle S, Marabelle, Aurélien, Melero, Ignacio, Brown, Brian D, Brody, Joshua D

“…After several decades, therapeutic cancer vaccines now show signs of efficacy and potential to help patients resistant to other standard-of-care…”
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Kinetic Analysis Reveals the Fate of a MicroRNA following Target Regulation in Mammalian Cells by Baccarini, Alessia, Chauhan, Hemangini, Gardner, Thomas J., Jayaprakash, Anitha D., Sachidanandam, Ravi, Brown, Brian D.

“…Considerable details about microRNA (miRNA) biogenesis and regulation have been uncovered, but little is known about the fate of the miRNA subsequent to target…”
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TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation by Nair-Gupta, Priyanka, Baccarini, Alessia, Tung, Navpreet, Seyffer, Fabian, Florey, Oliver, Huang, Yunjie, Banerjee, Meenakshi, Overholtzer, Michael, Roche, Paul A., Tampé, Robert, Brown, Brian D., Amsen, Derk, Whiteheart, Sidney W., Blander, J. Magarian

“…Adaptation of the endoplasmic reticulum (ER) pathway for MHC class I (MHC-I) presentation in dendritic cells enables cross-presentation of peptides derived…”
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GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells by Greter, Melanie, Helft, Julie, Chow, Andrew, Hashimoto, Daigo, Mortha, Arthur, Agudo-Cantero, Judith, Bogunovic, Milena, Gautier, Emmanuel L., Miller, Jennifer, Leboeuf, Marylene, Lu, Geming, Aloman, Costica, Brown, Brian D., Pollard, Jeffrey W., Xiong, Huabao, Randolph, Gwendalyn J., Chipuk, Jerry E., Frenette, Paul S., Merad, Miriam

“…GM-CSF (Csf-2) is a critical cytokine for the in vitro generation of dendritic cells (DCs) and is thought to control the development of inflammatory DCs and…”
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The cis-Regulatory Atlas of the Mouse Immune System by Yoshida, Hideyuki, Lareau, Caleb A., Ramirez, Ricardo N., Rose, Samuel A., Maier, Barbara, Wroblewska, Aleksandra, Desland, Fiona, Chudnovskiy, Aleksey, Mortha, Arthur, Dominguez, Claudia, Tellier, Julie, Kim, Edy, Dwyer, Dan, Shinton, Susan, Nabekura, Tsukasa, Qi, YiLin, Yu, Bingfei, Robinette, Michelle, Kim, Ki-Wook, Wagers, Amy, Rhoads, Andrew, Nutt, Stephen L., Brown, Brian D., Mostafavi, Sara, Buenrostro, Jason D., Benoist, Christophe

“…A complete chart of cis-regulatory elements and their dynamic activity is necessary to understand the transcriptional basis of differentiation and function of…”
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Identification and remediation of biases in the activity of RNA ligases in small-RNA deep sequencing by Jayaprakash, Anitha D., Jabado, Omar, Brown, Brian D., Sachidanandam, Ravi

“…Deep sequencing of small RNAs (sRNA-seq) is now the gold standard for small RNA profiling and discovery. Biases in sRNA-seq have been reported, but their…”
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High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries by Mullokandov, Gavriel, Baccarini, Alessia, Ruzo, Albert, Jayaprakash, Anitha D, Tung, Navpreet, Israelow, Benjamin, Evans, Matthew J, Sachidanandam, Ravi, Brown, Brian D

“…Two large-scale resources for studying microRNA function are presented: one is a library of fluorescent sensors with a corresponding assay for global profiling…”
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CSF-1 controls cerebellar microglia and is required for motor function and social interaction by Kana, Veronika, Desland, Fiona A, Casanova-Acebes, Maria, Ayata, Pinar, Badimon, Ana, Nabel, Elisa, Yamamuro, Kazuhiko, Sneeboer, Marjolein, Tan, I-Li, Flanigan, Meghan E, Rose, Samuel A, Chang, Christie, Leader, Andrew, Le Bourhis, Hortense, Sweet, Eric S, Tung, Navpreet, Wroblewska, Aleksandra, Lavin, Yonit, See, Peter, Baccarini, Alessia, Ginhoux, Florent, Chitu, Violeta, Stanley, E Richard, Russo, Scott J, Yue, Zhenyu, Brown, Brian D, Joyner, Alexandra L, De Witte, Lotje D, Morishita, Hirofumi, Schaefer, Anne, Merad, Miriam

“…Microglia, the brain resident macrophages, critically shape forebrain neuronal circuits. However, their precise function in the cerebellum is unknown. Here we…”
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miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy by Oh, Jae Gyun, Watanabe, Shin, Lee, Ahyoung, Gorski, Przemek A, Lee, Philyoung, Jeong, Dongtak, Liang, Lifan, Liang, Yaxuan, Baccarini, Alessia, Sahoo, Susmita, Brown, Brian D, Hajjar, Roger J, Kho, Changwon

“…RATIONALE:Abnormal SUMOylation has emerged as a characteristic of heart failure (HF) pathology. Previously, we found reduced SUMO1 (small ubiquitin-like…”
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microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial–mesenchymal transition by Parikh, Aditya, Lee, Christine, Joseph, Peronne, Marchini, Sergio, Baccarini, Alessia, Kolev, Valentin, Romualdi, Chiara, Fruscio, Robert, Shah, Hardik, Wang, Feng, Mullokandov, Gavriel, Fishman, David, D’Incalci, Maurizio, Rahaman, Jamal, Kalir, Tamara, Redline, Raymond W., Brown, Brian D., Narla, Goutham, DiFeo, Analisa

“…Ovarian cancer is a leading cause of cancer deaths among women. Effective targets to treat advanced epithelial ovarian cancer (EOC) and biomarkers to predict…”
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Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity by Svensson-Arvelund, Judit, Cuadrado-Castano, Sara, Pantsulaia, Gvantsa, Kim, Kristy, Aleynick, Mark, Hammerich, Linda, Upadhyay, Ranjan, Yellin, Michael, Marsh, Henry, Oreper, Daniel, Jhunjhunwala, Suchit, Moussion, Christine, Merad, Miriam, Brown, Brian D., García-Sastre, Adolfo, Brody, Joshua D.

“…Immunotherapies directly enhancing anti-tumor CD8 + T cell responses have yielded measurable but limited success, highlighting the need for alternatives…”
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The miR-126–VEGFR2 axis controls the innate response to pathogen-associated nucleic acids by Agudo, Judith, Ruzo, Albert, Tung, Navpreet, Salmon, Hélène, Leboeuf, Marylène, Hashimoto, Daigo, Becker, Christian, Garrett-Sinha, Lee-Ann, Baccarini, Alessia, Merad, Miriam, Brown, Brian D

“…Plasmacytoid dendritic cells produce copious amounts of type I interferon in response to viral infection. Brown and colleagues show that the homeostasis and…”
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Mapping the effects of drugs on the immune system by Kidd, Brian A, Wroblewska, Aleksandra, Boland, Mary R, Agudo, Judith, Merad, Miriam, Tatonetti, Nicholas P, Brown, Brian D, Dudley, Joel T

“…The effects of drugs on the immune system is predicted by a data integration method. Understanding how drugs affect the immune system has consequences for…”
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A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice by Brown, Brian D., Cantore, Alessio, Annoni, Andrea, Sergi, Lucia Sergi, Lombardo, Angelo, Della Valle, Patrizia, D'Angelo, Armando, Naldini, Luigi

“…A longstanding goal for the treatment of hemophilia B is the development of a gene transfer strategy that can maintain sustained production of clotting factor…”
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Cbx8 Acts Non-canonically with Wdr5 to Promote Mammary Tumorigenesis by Chung, Chi-Yeh, Sun, Zhen, Mullokandov, Gavriel, Bosch, Almudena, Qadeer, Zulekha A., Cihan, Esma, Rapp, Zachary, Parsons, Ramon, Aguirre-Ghiso, Julio A., Farias, Eduardo F., Brown, Brian D., Gaspar-Maia, Alexandre, Bernstein, Emily

“…Chromatin-mediated processes influence the development and progression of breast cancer. Using murine mammary carcinoma-derived tumorspheres as a functional…”
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Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors by Israelow, Benjamin, Mullokandov, Gavriel, Agudo, Judith, Sourisseau, Marion, Bashir, Ali, Maldonado, Andres Y., Dar, Arvin C., Brown, Brian D., Evans, Matthew J.

“…Hepatitis C virus (HCV) replication is dependent on a liver-specific microRNA (miRNA), miR-122. A recent clinical trial reported that transient inhibition of…”
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Genomic instability during reprogramming by nuclear transfer is DNA replication dependent by Chia, Gloryn, Agudo, Judith, Treff, Nathan, Sauer, Mark V., Billing, David, Brown, Brian D., Baer, Richard, Egli, Dieter

“…Somatic cells can be reprogrammed to a pluripotent state by nuclear transfer into oocytes, yet developmental arrest often occurs. While incomplete…”
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