Search Results - "Brown, Abraham M"

Zinc Irreversibly Damages Major Enzymes of Energy Production and Antioxidant Defense Prior to Mitochondrial Permeability Transition by Gazaryan, Irina G., Krasinskaya, Inna P., Kristal, Bruce S., Brown, Abraham M.

“…Recent observations point to the role played by Zn2+ as an inducer of neuronal death. Two Zn2+ targets have been identified that result in inhibition of…”
Get full text

Role of the Polyol Pathway in Locomotor Recovery and Wallerian Degeneration after Spinal Cord Contusion Injury by Zeman, Richard J., Wen, Xialing, Ouyang, Nengtai, Brown, Abraham M., Etlinger, Joseph D.

“…Spinal cord contusion injury leads to Wallerian degeneration of axonal tracts, resulting in irreversible paralysis. Contusion injury causes perfusion loss by…”
Get full text

Zinc Is a Potent Inhibitor of Thiol Oxidoreductase Activity and Stimulates Reactive Oxygen Species Production by Lipoamide Dehydrogenase by Gazaryan, Irina G., Krasnikov, Boris F., Ashby, Gillian A., Thorneley, Roger N.F., Kristal, Bruce S., Brown, Abraham M.

“…Submicromolar zinc inhibits α-ketoglutarate-dependent mitochondrial respiration. This was attributed to inhibition of the α-ketoglutarate dehydrogenase complex…”
Get full text

Kinetic Model for Ca2+-induced Permeability Transition in Energized Liver Mitochondria Discriminates between Inhibitor Mechanisms by Baranov, Sergei V., Stavrovskaya, Irina G., Brown, Abraham M., Tyryshkin, Alexei M., Kristal, Bruce S.

“…Cytotoxicity associated with pathophysiological Ca2+ overload (e.g. in stroke) appears mediated by an event termed the mitochondrial permeability transition…”
Get full text

Tempol, a Superoxide Dismutase Mimetic, Inhibits Wallerian Degeneration Following Spinal Cord Injury by Preventing Glutathione Depletion and Aldose Reductase Activation by Zeman, Richard J, Brown, Abraham M, Wen, Xialing, Ouyang, Nengtai, Etlinger, Joseph D

“…Spinal cord contusion injury results in Wallerian degeneration of spinal cord axonal tracts, which are necessary for locomotor function. Axonal swelling and…”
Get more information

Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology by Stavrovskaya, Irina G, Narayanan, Malini V, Zhang, Wenhua, Krasnikov, Boris F, Heemskerk, Jill, Young, S Stanley, Blass, John P, Brown, Abraham M, Beal, M Flint, Friedlander, Robert M, Kristal, Bruce S

“…Substantial evidence indicates that mitochondria are a major checkpoint in several pathways leading to neuronal cell death, but discerning critical propagation…”
Get full text

The mitochondrial permeability transition as a target for neuroprotection by Kristal, Bruce S, Stavrovskaya, Irina G, Narayanan, Malini V, Krasnikov, Boris F, Brown, Abraham M, Beal, M Flint, Friedlander, Robert M

“…Mitochondria serve as checkpoints and amplifiers on cell death pathways. In the central nervous system, mitochondrial involvement seems essential for normal…”
Get full text

Genome-wide Association Study of Genetic Loci and Alzheimer Disease by Brown, Abraham M, Finch, Stephen J, Gordon, Derek

Get full text

Intersection between mitochondrial permeability pores and mitochondrial fusion/fission by Gazaryan, Irina G, Brown, Abraham M

“…The goal of this review is to highlight recent developments in the field of mitochondrial membrane processes, which provide new insights into the relation…”
Get full text

Apoptogenic Ganglioside GD3 Directly Induces the Mitochondrial Permeability Transition by Kristal, Bruce S., Brown, Abraham M.

“…Early events in apoptotic cascades initiated by ceramides or by activation of the surface receptor CD95 (Fas/APO-1) include the formation of ganglioside GD3…”
Get full text

pH-dependent substrate preference of pig heart lipoamide dehydrogenase varies with oligomeric state: response to mitochondrial matrix acidification by Klyachko, Natalia L, Shchedrina, Valentina A, Efimov, Alexander V, Kazakov, Sergey V, Gazaryan, Irina G, Kristal, Bruce S, Brown, Abraham M

“…Cycling of intracellular pH has recently been shown to play a critical role in ischemia-reperfusion injury. Ischemia-reperfusion also leads to mitochondrial…”
Get full text

Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria by Kristal, Bruce S, Conway, Ann D, Brown, Abraham M, Jain, Jinesh C, Ulluci, Paul A, Li, Shu Wen, Burke, William J

“…Parkinson’s disease (PD) is a major cause of age-related morbidity and mortality, present in nearly 1% of individuals at ages 70–79 and ∼2.5% of individuals at…”
Get full text

Comparative kinetic analysis reveals that inducer-specific ion release precedes the mitochondrial permeability transition by Krasnikov, Boris F., Zorov, Dmitry B., Antonenko, Yuri N., Zaspa, Andrey A., Kulikov, Igor V., Kristal, Bruce S., Cooper, Arthur J.L., Brown, Abraham M.

“…Relationships among the multiple events that precede the mitochondrial membrane permeability transition (MPT) are not yet clearly understood. A combination of…”
Get full text

Testing for linkage and association across the dihydrolipoyl dehydrogenase gene region with Alzheimer's disease in three sample populations by Brown, Abraham M, Gordon, Derek, Lee, Hsinhwa, Wavrant-De Vrièze, Fabienne, Cellini, Elena, Bagnoli, Silvia, Nacmias, Benedetta, Sorbi, Sandro, Hardy, John, Blass, John P

“…Prior case-control studies from our laboratory of a population enriched with individuals of Ashkenazi Jewish descent suggested that association exists between…”
Get full text

Increase in linkage information by stratification of pedigree data into gold-standard and standard diagnoses: application to the NIMH Alzheimer Disease Genetics Initiative Dataset by Gordon, Derek, Haynes, Chad, Finch, Stephen J, Brown, Abraham M

“…Patients diagnosed with a standard clinical method (subject to misclassification error) are often combined with patients diagnosed with a gold-standard method…”
Get more information

Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population by Brown, Abraham M., Gordon, Derek, Lee, Hsinhwa, Caudy, Michael, Hardy, John, Haroutunian, Vahram, Blass, John P.

“…Abundant biochemical evidence links deficient activity of mitochondrial α‐ketoglutarate dehydrogenase with neuropathologically confirmed Alzheimer's disease…”
Get full text

pH-dependent Substrate Preference of Pig Heart Lipoamide Dehydrogenase Varies with Oligomeric State by Klyachko, Natalia L., Shchedrina, Valentina A., Efimov, Alexander V., Kazakov, Sergey V., Gazaryan, Irina G., Kristal, Bruce S., Brown, Abraham M.

“…Cycling of intracellular pH has recently been shown to play a critical role in ischemia-reperfusion injury. Ischemia-reperfusion also leads to mitochondrial…”
Get full text

Neuronal Subclass-Selective Loss of Pyruvate Dehydrogenase Immunoreactivity Following Canine Cardiac Arrest and Resuscitation by Bogaert, Yolanda E., Sheu, Kwan-Fu Rex, Hof, Patrick R., Brown, Abraham M., Blass, John P., Rosenthal, Robert E., Fiskum, Gary

“…Chronic impairment of aerobic energy metabolism accompanies global cerebral ischemia and reperfusion and likely contributes to delayed neuronal cell death…”
Get full text

Substantial linkage disequilibrium across the dihydrolipoyl succinyltransferase gene region without Alzheimer's disease association by Brown, Abraham M, Gordon, Derek, Lee, Hsinhwa, Caudy, Michael, Haroutunian, Vahram, Blass, John P

“…Association of the candidate gene DLST with late-onset Alzheimer's disease (LOAD) risk has been suggested on the basis of case-control studies. This gene,…”
Get full text

Correlation of the clinical severity of Alzheimer's disease with an aberration in mitochondrial DNA (mtDNA) by Brown, A M, Sheu, R K, Mohs, R, Haroutunian, V, Blass, J P

“…Controversy exists about which of the well-established neurobiological abnormalities in Alzheimer's disease (AD) relate directly to the clinical disabilities…”
Get full text