Search Results - "Brouwers, Martijn C"

Non-alcoholic fatty liver disease and cardiovascular disease: assessing the evidence for causality by Brouwers, Martijn C. G. J., Simons, Nynke, Stehouwer, Coen D. A., Isaacs, Aaron

“…Non-alcoholic fatty liver disease (NAFLD) is highly prevalent among individuals with type 2 diabetes. Although epidemiological studies have shown that NAFLD is…”
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Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial by Petrie, John R, Prof, Chaturvedi, Nishi, Prof, Ford, Ian, Prof, Brouwers, Martijn C G J, MD, Greenlaw, Nicola, MSc, Tillin, Therese, MBBS, Hramiak, Irene, Prof, Hughes, Alun D, Prof, Jenkins, Alicia J, Prof, Klein, Barbara E K, Prof, Klein, Ronald, Prof, Ooi, Teik C, Dr, Rossing, Peter, Prof, Stehouwer, Coen D A, Prof, Sattar, Naveed, Prof, Colhoun, Helen M, Prof

“…Summary Background Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 diabetes, but whether it has cardiovascular…”
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Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: A systematic review and meta-analysis by Simons, Pomme I H G, Simons, Nynke, Stehouwer, Coen D A, Schalkwijk, Casper G, Schaper, Nicolaas C, Brouwers, Martijn C G J

“…Small-molecules that disrupt the binding between glucokinase and glucokinase regulatory protein (GKRP) in the liver represent a potential new class of…”
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Serum sex hormone-binding globulin is a mediator of the association between intrahepatic lipid content and type 2 diabetes: the Maastricht Study by Simons, Pomme I. H. G., Valkenburg, Olivier, van de Waarenburg, Marjo P. H., van Greevenbroek, Marleen M. J., Kooi, M. Eline, Jansen, Jacobus F. A., Schalkwijk, Casper G., Stehouwer, Coen D. A., Brouwers, Martijn C. G. J.

“…Aims/hypothesis Serum sex hormone-binding globulin (SHBG) has been proposed to act as a hepatokine that contributes to the extrahepatic complications observed…”
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Towards precision medicine in diabetes? A critical review of glucotypes by Hulman, Adam, Foreman, Yuri D, Brouwers, Martijn C G J, Kroon, Abraham A, Reesink, Koen D, Dagnelie, Pieter C, van der Kallen, Carla J H, Greevenbroek, Marleen M J van, Færch, Kristine, Vistisen, Dorte, Jørgensen, Marit E, Stehouwer, Coen D A, Witte, Daniel R

“…In response to a study previously published in PLOS Biology, this Formal Comment thoroughly examines the concept of 'glucotypes' with regard to its…”
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Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study by Foreman, Yuri D., van Doorn, William P. T. M., Schaper, Nicolaas C., van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Henry, Ronald M. A., Koster, Annemarie, Eussen, Simone J. P. M., Wesselius, Anke, Reesink, Koen D., Schram, Miranda T., Dagnelie, Pieter C., Kroon, Abraham A., Brouwers, Martijn C. G. J., Stehouwer, Coen D. A.

“…Aims CVD is the main cause of morbidity and mortality in individuals with diabetes. It is currently unclear whether daily glucose variability contributes to…”
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Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study by de Ritter, Rianneke, Sep, Simone J. S., van Greevenbroek, Marleen M. J., Kusters, Yvo H. A. M., Vos, Rimke C., Bots, Michiel L., Kooi, M. Eline, Dagnelie, Pieter C., Eussen, Simone J. P. M., Schram, Miranda T., Koster, Annemarie, Brouwers, Martijn C. G., van der Sangen, Niels M. R., Peters, Sanne A. E., van der Kallen, Carla J. H., Stehouwer, Coen D. A.

“…Aims/hypothesis Obesity is a major risk factor for type 2 diabetes. However, body composition differs between women and men. In this study we investigate the…”
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Cognitive Profile and Mental Health in Adult Phenylketonuria: A PKU-COBESO Study by Jahja, Rianne, Huijbregts, Stephan C. J., de Sonneville, Leo M. J., van der Meere, Jaap J., Legemaat, Amanda M., Bosch, Annet M., Hollak, Carla E. M., Rubio-Gozalbo, M. Estela, Brouwers, Martijn C. G. J., Hofstede, Floris C., de Vries, Maaike C., Janssen, Mirian C. H., van der Ploeg, Ans T., Langendonk, Janneke G., van Spronsen, Francjan J.

“…Objective: Despite early dietary treatment phenylketonuria patients have lower IQ and poorer executive functions compared to healthy controls. Cognitive…”
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Social-cognitive functioning and social skills in patients with early treated phenylketonuria: a PKU-COBESO study by Jahja, Rianne, van Spronsen, Francjan J., de Sonneville, Leo M. J., van der Meere, Jaap J., Bosch, Annet M., Hollak, Carla E. M., Rubio-Gozalbo, M. Estela, Brouwers, Martijn C. G. J., Hofstede, Floris C., de Vries, Maaike C., Janssen, Mirian C. H., van der Ploeg, Ans T., Langendonk, Janneke G., Huijbregts, Stephan C. J.

“…Objective Early treatment of phenylketonuria (ET-PKU) prevents mental retardation, but many patients still show cognitive and mood problems. In this study, it…”
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Long-Term Follow-Up of Cognition and Mental Health in Adult Phenylketonuria: A PKU-COBESO Study by Jahja, Rianne, van Spronsen, Francjan J., de Sonneville, Leo M. J., van der Meere, Jaap J., Bosch, Annet M., Hollak, Carla E. M., Rubio-Gozalbo, M. Estela, Brouwers, Martijn C. G. J., Hofstede, Floris C., de Vries, Maaike C., Janssen, Mirian C. H., van der Ploeg, Ans T., Langendonk, Janneke G., Huijbregts, Stephan C. J.

“…Cognitive and mental health problems in individuals with the inherited metabolic disorder phenylketonuria (PKU) have often been associated with metabolic…”
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Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance by Roumans, Kay H. M., Lindeboom, Lucas, Veeraiah, Pandichelvam, Remie, Carlijn M. E., Phielix, Esther, Havekes, Bas, Bruls, Yvonne M. H., Brouwers, Martijn C. G. J., Ståhlman, Marcus, Alssema, Marjan, Peters, Harry P. F., de Mutsert, Renée, Staels, Bart, Taskinen, Marja-Riitta, Borén, Jan, Schrauwen, Patrick, Schrauwen-Hinderling, Vera B.

“…Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin…”
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Thiazolidinediones and Glucagon‐Like Peptide‐1 Receptor Agonists and the Risk of Nonalcoholic Fatty Liver Disease: A Cohort Study by Dalem, Judith, Driessen, Johanna H. M., Burden, Andrea M., Stehouwer, Coen D. A., Klungel, Olaf H., Vries, Frank, Brouwers, Martijn C. G. J.

“…Background and Aims Thiazolidinediones (TZDs) and glucagon‐like peptide‐1 (GLP‐1) receptor agonists are potential pharmacological treatment options for…”
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Relevant patient characteristics for estimating healthcare needs according to healthcare providers and people with type 2 diabetes: a Delphi survey by Hertroijs, Dorijn F L, Brouwers, Martijn C G J, Elissen, Arianne M J, Schaper, Nicolaas C, Ruwaard, Dirk

“…Recently, there has been growing interest in providing more tailored, patient-centered care for the treatment of type 2 diabetes mellitus (T2DM). Yet it…”
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The association of type 2 diabetes‐related characteristics with fracture risk at different sites by Hulten, Veerle, Souverein, Patrick C., Starup‐Linde, Jakob, Viggers, Rikke, Klungel, Olaf H., Vestergaard, Peter, Brouwers, Martijn C. J. G., Bergh, Joop P., Driessen, Johanna H. M.

“…Aim To determine the association of diabetes‐related characteristics with fractures at different sites in individuals with type 2 diabetes (T2D). Materials and…”
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Machine learning-based glucose prediction with use of continuous glucose and physical activity monitoring data: The Maastricht Study by van Doorn, William P T M, Foreman, Yuri D, Schaper, Nicolaas C, Savelberg, Hans H C M, Koster, Annemarie, van der Kallen, Carla J H, Wesselius, Anke, Schram, Miranda T, Henry, Ronald M A, Dagnelie, Pieter C, de Galan, Bastiaan E, Bekers, Otto, Stehouwer, Coen D A, Meex, Steven J R, Brouwers, Martijn C G J

“…Closed-loop insulin delivery systems, which integrate continuous glucose monitoring (CGM) and algorithms that continuously guide insulin dosing, have been…”
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Patients With Aldolase B Deficiency Are Characterized by Increased Intrahepatic Triglyceride Content by Simons, Nynke, Debray, François-Guillaume, Schaper, Nicolaas C, Kooi, M Eline, Feskens, Edith J M, Hollak, Carla E M, Lindeboom, Lucas, Koek, Ger H, Bons, Judith A P, Lefeber, Dirk J, Hodson, Leanne, Schalkwijk, Casper G, Stehouwer, Coen D A, Cassiman, David, Brouwers, Martijn C G J

“…Abstract Context There is an ongoing debate about whether and how fructose is involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). A…”
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A risk score including body mass index, glycated haemoglobin and triglycerides predicts future glycaemic control in people with type 2 diabetes by Hertroijs, Dorijn F. L., Elissen, Arianne M. J., Brouwers, Martijn C. G. J., Schaper, Nicolaas C., Köhler, Sebastian, Popa, Mirela C., Asteriadis, Stylianos, Hendriks, Steven H., Bilo, Henk J., Ruwaard, Dirk

“…Aim To identify, predict and validate distinct glycaemic trajectories among patients with newly diagnosed type 2 diabetes treated in primary care, as a first…”
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Causal relationship between polycystic ovary syndrome and coronary artery disease: A Mendelian randomisation study by Simons, Pomme I. H. G., Cornelissen, Merel E. B., Valkenburg, Olivier, Onland‐Moret, N. Charlotte, Schouw, Yvonne T., Stehouwer, Coen D.A., Burgess, Stephen, Brouwers, Martijn C. G. J.

“…Objective Polycystic ovary syndrome (PCOS) has been associated with an increased risk of coronary artery disease (CAD). However, it remains uncertain whether…”
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Metformin and carotid intima‐media thickness in never‐smokers with type 1 diabetes: The REMOVAL trial by Timmons, Joseph G., Greenlaw, Nicola, Boyle, James G., Chaturvedi, Nish, Ford, Ian, Brouwers, Martijn C. G. J., Tillin, Therese, Hramiak, Irene, Hughes, Alun D., Jenkins, Alicia J., Klein, Barbara E. K., Klein, Ron, Ooi, Teik C., Rossing, Peter, Stehouwer, Coen D. A., Sattar, Naveed, Colhoun, Helen M., Petrie, John R.

“…Aim To determine whether metformin's effects on carotid artery intima‐media thickness (cIMT) in type 1 diabetes differ according to smoking status. Methods…”
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Movement disorders and nonmotor neuropsychological symptoms in children and adults with classical galactosemia by Kuiper, Anouk, Grünewald, Stephanie, Murphy, Elaine, Coenen, Maraike A., Eggink, Hendriekje, Zutt, Rodi, Rubio‐Gozalbo, Maria E., Bosch, Annet M., Williams, Monique, Derks, Terry G. J., Lachmann, Robin H. L., Brouwers, Martijn C. G. J., Janssen, Mirian C. H., Tijssen, Marina A., de Koning, Tom J.

“…Although movement disorders (MDs) are known complications, the exact frequency and severity remains uncertain in patients with classical galactosemia,…”
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