Hypospadias: a transgenerational effect of diethylstilbestrol?

Hypospadias: a transgenerational effect of diethylstilbestrol?

BACKGROUND: In 2002, an increased risk of hypospadias was reported for sons of women exposed to diethylstilbestrol (DES) in utero, suggesting transgenerational effects of DES. The aim of this study was to further assess the association between parental DES exposure and hypospadias in a case–referent...

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Bibliographic Details
Published in:Human reproduction (Oxford) Vol. 21; no. 3; pp. 666 - 669
Main Authors: Brouwers, M.M., Feitz, W.F.J., Roelofs, L.A.J., Kiemeney, L.A.L.M., de Gier, R.P.E., Roeleveld, N.
Format: Journal Article
Language:English
Published: Oxford Oxford University Press 01-03-2006
Oxford Publishing Limited (England)
Subjects:
Biological and medical sciences
diethylstilbestrol
Diethylstilbestrol - toxicity
Female
Gynecology. Andrology. Obstetrics
Humans
hypospadias
Hypospadias - chemically induced
Hypospadias - epidemiology
Male
Medical sciences
Netherlands
offspring
Pregnancy
Prenatal Exposure Delayed Effects
Risk Factors
transgenerational effects
Netherlands
offspring
hypospadias
transgenerational effects
diethylstilbestrol
Antineoplastic agent
Agonist
Urinary system disease
Urethral disease
Hypospadias
Estrogen
diethylstilbestrol/hypospadias/offspring/transgenerational effects
Urinary tract disease
Ovarian hormone
Vertebrata
Mammalia
Malformation
Diethylstilbestrol
Sex steroid hormone
Hormonal receptor
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Summary:BACKGROUND: In 2002, an increased risk of hypospadias was reported for sons of women exposed to diethylstilbestrol (DES) in utero, suggesting transgenerational effects of DES. The aim of this study was to further assess the association between parental DES exposure and hypospadias in a case–referent study. METHODS: Cases with hypospadias were retrieved from the hospital information system. Referents were recruited via the parents of cases. Both parents completed postal questionnaires. Associations were estimated by odds ratios (OR) with 95% confidence intervals (CI). Additionally, conditional logistic regression analyses were performed for a matched subset of parents. RESULTS: The final database included 583 cases and 251 referents. In the initial analyses, an indication was found for an increased risk of hypospadias when mothers were exposed to DES in utero: OR = 2.3 (95% CI 0.7–7.9). Conditional logistic regression resulted in a stronger risk estimate: OR = 4.9 (95% CI 1.1–22.3). Paternal exposure to DES did not increase the risk. CONCLUSIONS: The results confirm an increased risk of hypospadias when mothers were exposed to DES in utero. However, the excess risk appears to be of much smaller magnitude than in the 2002 study. Further research on the potential health risks for the third generation is of great importance.
Bibliography:3To whom correspondence should be addressed. E-mail: M.Brouwers@epib.umcn.nl
local:398
ark:/67375/HXZ-XTMJHZCG-3
istex:C8A2C02975E9B75E3FCC4FE79826F7BF60FA4687
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/dei398