Search Results - "Brouwer, Kim L.R"

Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids by Lan, Ke, Su, Mingming, Xie, Guoxiang, Ferslew, Brian C, Brouwer, Kim L.R, Rajani, Cynthia, Liu, Changxiao, Jia, Wei

“…Host-gut microbial interactions contribute to human health and disease states and an important manifestation resulting from this cometabolism is a vast…”
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Effect of Liver Disease on Hepatic Transporter Expression and Function by Thakkar, Nilay, Slizgi, Jason R, Brouwer, Kim L R

“…Liver disease can alter the disposition of xenobiotics and endogenous substances. Regulatory agencies such as the Food and Drug Administration and the European…”
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Disease‐Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium by Evers, Raymond, Piquette‐Miller, Micheline, Polli, Joseph W., Russel, Frans G.M., Sprowl, Jason A., Tohyama, Kimio, Ware, Joseph A., Wildt, Saskia N., Xie, Wen, Brouwer, Kim L.R.

“…Drug transporters are critically important for the absorption, distribution, metabolism, and excretion (ADME) of many drugs and endogenous compounds…”
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Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches by Guo, Yingying, Chu, Xiaoyan, Parrott, Neil J., Brouwer, Kim L.R., Hsu, Vicky, Nagar, Swati, Matsson, Pär, Sharma, Pradeep, Snoeys, Jan, Sugiyama, Yuichi, Tatosian, Daniel, Unadkat, Jashvant D., Huang, Shiew‐Mei, Galetin, Aleksandra, Hoeben, Eef, Chen, Dapeng, Hartmann, Georgy, Menzel, Karsten

“…This white paper examines recent progress, applications, and challenges in predicting unbound and total tissue and intra/subcellular drug concentrations using…”
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The role of hepatic transporters in drug disposition and elimination by Brouwer, Kim L.R.

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In vitro to in vivo extrapolation for high throughput prioritization and decision making by Bell, Shannon M., Chang, Xiaoqing, Wambaugh, John F., Allen, David G., Bartels, Mike, Brouwer, Kim L.R., Casey, Warren M., Choksi, Neepa, Ferguson, Stephen S., Fraczkiewicz, Grazyna, Jarabek, Annie M., Ke, Alice, Lumen, Annie, Lynn, Scott G., Paini, Alicia, Price, Paul S., Ring, Caroline, Simon, Ted W., Sipes, Nisha S., Sprankle, Catherine S., Strickland, Judy, Troutman, John, Wetmore, Barbara A., Kleinstreuer, Nicole C.

“…In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To…”
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An updated review on drug-induced cholestasis: mechanisms and investigation of physicochemical properties and pharmacokinetic parameters by Yang, Kyunghee, Köck, Kathleen, Sedykh, Alexander, Tropsha, Alexander, Brouwer, Kim L R

“…Drug-induced cholestasis is an important form of acquired liver disease and is associated with significant morbidity and mortality. Bile acids are key…”
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Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids by Zhu, Pingping, Zhang, Jian, Chen, Yujie, Yin, Shanshan, Su, Mingming, Xie, Guoxiang, Brouwer, Kim L. R., Liu, Changxiao, Lan, Ke, Jia, Wei

“…Host-gut microbiota metabolic interactions are closely associated with health and disease. A manifestation of such co-metabolism is the vast structural…”
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Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective by Kenna, J. Gerry, Taskar, Kunal S., Battista, Christina, Bourdet, David L., Brouwer, Kim L.R., Brouwer, Kenneth R., Dai, David, Funk, Christoph, Hafey, Michael J., Lai, Yurong, Maher, Jonathan, Pak, Y. Anne, Pedersen, Jenny M., Polli, Joseph W., Rodrigues, A. David, Watkins, Paul B., Yang, Kyunghee, Yucha, Robert W.

“…Bile salt export pump (BSEP) inhibition has emerged as an important mechanism that may contribute to the initiation of human drug‐induced liver injury (DILI)…”
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Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors by Woodhead, Jeffrey L, Brock, William J, Roth, Sharin E, Shoaf, Susan E, Brouwer, Kim L R, Church, Rachel, Grammatopoulos, Tom N, Stiles, Linsey, Siler, Scott Q, Howell, Brett A, Mosedale, Merrie, Watkins, Paul B, Shoda, Lisl K M

“…Tolvaptan is a selective vasopressin V2 receptor antagonist, approved in several countries for the treatment of hyponatremia and autosomal dominant polycystic…”
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Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics by Pfeifer, Nathan D, Hardwick, Rhiannon N, Brouwer, Kim L R

“…Hepatic efflux transporters include numerous well-known and emerging proteins localized to the canalicular or basolateral membrane of the hepatocyte that are…”
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Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury by Yang, Kyunghee, Guo, Cen, Woodhead, Jeffrey L, St Claire, 3rd, Robert L, Watkins, Paul B, Siler, Scott Q, Howell, Brett A, Brouwer, Kim L R

“…Sandwich-cultured hepatocytes (SCH) are metabolically competent and have proper localization of basolateral and canalicular transporters with functional bile…”
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Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells by Malinen, Melina M., Ito, Katsuaki, Kang, Hee Eun, Honkakoski, Paavo, Brouwer, Kim L.R.

“…Human-derived hepatic cell lines are a valuable alternative to primary hepatocytes for drug metabolism, transport and toxicity studies. However, their…”
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Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease by Bezençon, Jacqueline, Beaudoin, James J, Ito, Katsuaki, Fu, Dong, Roth, Sharin E, Brock, William J, Brouwer, Kim L R

“…Autosomal dominant polycystic kidney disease (ADPKD) is a common form of inherited polycystic kidney disease (PKD) and is a leading cause of kidney failure…”
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Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors by Griffin, Latoya, Annaert, Pieter, Brouwer, Kim L R

“…Protease inhibitors, a class of antiretroviral agents frequently used in the treatment of HIV infection, interact with numerous transport proteins resulting in…”
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Precision Dosing: Public Health Need, Proposed Framework, and Anticipated Impact by Gonzalez, Daniel, Rao, Gauri G., Bailey, Stacy C., Brouwer, Kim L.R., Cao, Yanguang, Crona, Daniel J., Kashuba, Angela D.M., Lee, Craig R., Morbitzer, Kathryn, Patterson, J. Herbert, Wiltshire, Tim, Easter, Jon, Savage, Scott W., Powell, J. Robert

“…Alternatively, unintentional over dosage due to small body size, impaired renal function, or a loss‐of‐function polymorphism in a metabolizing enzyme may…”
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Medication use and medical comorbidity in patients with chronic hepatitis C from a US commercial claims database: high utilization of drugs with interaction potential by Lauffenburger, Julie C, Mayer, Christina L, Hawke, Roy L, Brouwer, Kim L.R, Fried, Michael W, Farley, Joel F

“…BACKGROUNDWith the advent of the direct-acting antiviral agents, significant drug–drug interaction (DDI) potential now exists for patients treated for chronic…”
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Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury by Woodhead, Jeffrey L, Yang, Kyunghee, Siler, Scott Q, Watkins, Paul B, Brouwer, Kim L R, Barton, Hugh A, Howell, Brett A

“…Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile…”
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Integration of hepatic drug transporters and phase II metabolizing enzymes: Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites by Zamek-Gliszczynski, Maciej J., Hoffmaster, Keith A., Nezasa, Ken-ichi, Tallman, Melanie N., Brouwer, Kim L.R.

“…The liver is the primary site of drug metabolism in the body. Typically, metabolic conversion of a drug results in inactivation, detoxification, and enhanced…”
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Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO by Watt, Kevin M., Cohen‐Wolkowiez, Michael, Barrett, Jeffrey S., Sevestre, Michael, Zhao, Ping, Brouwer, Kim L.R., Edginton, Andrea N.

“…Extracorporeal life support (e.g., dialysis, extracorporeal membrane oxygenation (ECMO)) can affect drug disposition, placing patients at risk for therapeutic…”
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