Search Results - "Brouwer, Arwin J"

Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay by Vosyka, Oliver, Vinothkumar, Kutti R., Wolf, Eliane V., Brouwer, Arwin J., Liskamp, Rob M. J., Verhelst, Steven H. L.

“…Rhomboid proteases are evolutionary conserved intramembrane serine proteases. Because of their emerging role in many important biological pathways, rhomboids…”
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Broad-Spectrum Antimalarial Activity of Peptido Sulfonyl Fluorides, a New Class of Proteasome Inhibitors by TSCHAN, Serena, BROUWER, Arwin J, MORDMÜLLER, Benjamin, WERKHOVEN, Paul R, JONKER, Anika M, WAGNER, Lena, KNITTEL, Sarah, AMINAKE, Makoah Nigel, PRADEL, Gabriele, JOANNY, Fanny, LISKAMP, Rob M. J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry by Rijkers, Dirk T S, van Esse, G Wilma, Merkx, Remco, Brouwer, Arwin J, Jacobs, Hans J F, Pieters, Roland J, Liskamp, Rob M J

“…Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in…”
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Hydrolytic (In)stability of Methacrylate Esters in Covalently Cross-Linked Hydrogels Based on Chondroitin Sulfate and Hyaluronic Acid Methacrylate by Schuurmans, Carl C. L, Brouwer, Arwin J, Jong, Jacobus A. W, Boons, Geert-Jan P. H, Hennink, Wim E, Vermonden, Tina

“…Chondroitin sulfate (CS) and hyaluronic acid (HA) methacrylate (MA) hydrogels are under investigation for biomedical applications. Here, the hydrolytic…”
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Potent and Highly Selective Inhibitors of the Proteasome Trypsin-like Site by Incorporation of Basic Side Chain Containing Amino Acid Derived Sulfonyl Fluorides by Artschwager, Raik, Ward, David J, Gannon, Susan, Brouwer, Arwin J, van de Langemheen, Helmus, Kowalski, Hubert, Liskamp, Rob M. J

“…A unique category of basic side chain containing amino acid derived sulfonyl fluorides (SFs) has been synthesized for incorporation into new proteasome…”
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Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics by Guardiola, Salvador, Prades, Roger, Mendieta, Laura, Brouwer, Arwin J, Streefkerk, Jelle, Nevola, Laura, Tarragó, Teresa, Liskamp, Rob M J, Giralt, Ernest

“…Prolyl oligopeptidase (POP), a serine protease highly expressed in the brain, has recently emerged as an enticing therapeutic target for the treatment of…”
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Structure‐Based Design and Synthesis of Lipid A Derivatives to Modulate Cytokine Responses by Verpalen, Enrico C. J. M., Brouwer, Arwin J., Wolfert, Margreet A., Boons, Geert‐Jan

“…Agonists of Toll like receptors (TLRs) have attracted interest as adjuvants and immune modulators. A crystal structure of TLR4/MD2 with E. coli LPS indicates…”
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Peptide microarray analysis of the cross‐talk between O‐GlcNAcylation and tyrosine phosphorylation by Shi, Jie, Tomašič, Tihomir, Sharif, Suhela, Brouwer, Arwin J., Anderluh, Marko, Ruijtenbeek, Rob, Pieters, Roland J.

“…O‐GlcNAcylation of proteins regulates important cellular processes. A few reports noted that O‐GlcNAcylation exhibits cross‐talk with tyrosine phosphorylation…”
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Synthesis of monophosphoryl lipid A using 2-naphtylmethyl ethers as permanent protecting groups by Verpalen, Enrico C.J.M., Brouwer, Arwin J., Boons, Geert-Jan

“…Lipid A, which is a conserved component of lipopolysaccharides of gram-negative bacteria, has attracted considerable interest for the development of…”
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Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides by Brouwer, Arwin J., Herrero Álvarez, Natalia, Ciaffoni, Adriano, van de Langemheen, Helmus, Liskamp, Rob M.J.

“…[Display omitted] The success of inhibition of the proteasome by formation of covalent bonds is a major victory over the long held-view that this would lead to…”
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Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site by Dubiella, Christian, Cui, Haissi, Gersch, Malte, Brouwer, Arwin J., Sieber, Stephan A., Krüger, Achim, Liskamp, Rob M. J., Groll, Michael

“…The concept of proteasome inhibition ranks among the latest achievements in the treatment of blood cancer and represents a promising strategy for modulating…”
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Delayed fibril formation of amylin(20–29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis by Brouwer, Arwin J., Elgersma, Ronald C., Jagodzinska, Monika, Rijkers, Dirk T.S., Liskamp, Rob M.J.

“…The synthesis of a new peptidomimetic structure, the alkene dipeptidosulfonamide isostere, is described. The synthesis is based on a cross metathesis reaction…”
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Potential peptidic proteasome inhibitors by incorporation of an electrophilic trap based on amino acid derived α-substituted sulfonyl fluorides by Herrero Alvarez, Natalia, van de Langemheen, Helmus, Brouwer, Arwin J., Liskamp, Rob M.J.

“…[Display omitted] Peptido sulfonyl fluoride derivatives were designed and synthesized containing a substituent on the alpha position (αPSFs) with respect to…”
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Peptido Sulfonyl Fluorides as New Powerful Proteasome Inhibitors by Brouwer, Arwin J, Jonker, Anika, Werkhoven, Paul, Kuo, Ethan, Li, Nan, Gallastegui, Nerea, Kemmink, Johan, Florea, Bogdan I, Groll, Michael, Overkleeft, Herman S, Liskamp, Rob M. J

“…A new class of potent proteasome inhibitors is described, of which the members contain an amino acid inspired sulfonyl fluoride as the electrophilic trap. In…”
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Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes by Dijkgraaf, Ingrid, Rijnders, Anneloes Y, Soede, Annemieke, Dechesne, Annemarie C, van Esse, G Wilma, Brouwer, Arwin J, Corstens, Frans H M, Boerman, Otto C, Rijkers, Dirk T S, Liskamp, Rob M J

“…This report describes the design and synthesis of a series of alpha(V)beta(3) integrin-directed monomeric, dimeric and tetrameric cyclo[Arg-Gly-Asp-d-Phe-Lys]…”
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Expedient synthesis of a novel asymmetric selectively deprotectable derivative of the ATAC scaffold by Brouwer, Arwin J., van de Langemheen, Helmus, Liskamp, Rob M.J.

“…An efficient multigram scale synthesis of a new asymmetric triazacyclophane scaffold, the ATAC (Asymmetric-TAC) scaffold, bearing three selectively removable…”
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Thiourea-based spacers in potent divalent inhibitors of Pseudomonas aeruginosa virulence lectin LecA by Pukin, Aliaksei V, Brouwer, Arwin J, Koomen, Leonie, Quarles van Ufford, H C, Kemmink, Johan, de Mol, Nico J, Pieters, Roland J

“…A new divalent highly potent inhibitor of the Pseudomonas aeruginosa lectin and virulence factor LecA was prepared. It contains two thiourea linkages which…”
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Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap by Brouwer, Arwin J., Ceylan, Tarik, Jonker, Anika M., Linden, Tima van der, Liskamp, Rob M.J.

“…We have designed and synthesized novel irreversible serine protease inhibitors containing aliphatic sulfonyl fluorides as an electrophilic trap. These…”
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Synthesis of the TACO Scaffold as a New Selectively Deprotectable Conformationally Restricted Triazacyclophane Based Scaffold by Brouwer, Arwin J, van de Langemheen, Helmus, Ciaffoni, Adriano, Schilder, Kitty E, Liskamp, Rob M. J

“…The synthesis of a new triazacyclophane scaffold (TACO scaffold) containing three selectively deprotectable amines is described. The TACO scaffold is…”
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Scaffold optimization in discontinuous epitope containing protein mimics of gp120 using smart libraries by Mulder, Gwenn E, Quarles van Ufford, H Linda C, van Ameijde, Jeroen, Brouwer, Arwin J, Kruijtzer, John A W, Liskamp, Rob M J

“…A diversity of protein surface discontinuous epitope mimics is now rapidly and efficiently accessible. Despite the important role of protein-protein…”
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