Search Results - "Broughton, Brad Rs"

Post-stroke inflammation and the potential efficacy of novel stem cell therapies: focus on amnion epithelial cells by Broughton, Brad R S, Lim, Rebecca, Arumugam, Thiruma V, Drummond, Grant R, Wallace, Euan M, Sobey, Christopher G

“…Ischemic stroke is a debilitating disease for which there are currently no effective treatments besides the clot-buster, tissue plasminogen activator (t-PA),…”
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S-44-4: POST-STROKE SUPPLEMENTATION WITH SHORT-CHAIN FATTY ACIDS ACCELERATES RECOVERY IN MICE VIA THE G-PROTEIN COUPLED RECEPTORS by Peh, Alex, Dinakis, Evany, Mackay, Charles R, Broughton, Brad RS, Marques, Francine Z

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Immune Cell Infiltration in Malignant Middle Cerebral Artery Infarction: Comparison with Transient Cerebral Ischemia by Chu, Hannah X, Kim, Hyun Ah, Lee, Seyoung, Moore, Jeffrey P, Chan, Christopher T, Vinh, Antony, Gelderblom, Mathias, Arumugam, Thiruma V, Broughton, Brad RS, Drummond, Grant R, Sobey, Christopher G

“…We tested whether significant leukocyte infiltration occurs in a mouse model of permanent cerebral ischemia. C57BL6/J male mice underwent either permanent (3…”
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Inhibition of Nox2 oxidase activity ameliorates influenza A virus-induced lung inflammation by Vlahos, Ross, Stambas, John, Bozinovski, Steven, Broughton, Brad R S, Drummond, Grant R, Selemidis, Stavros

“…Influenza A virus pandemics and emerging anti-viral resistance highlight the urgent need for novel generic pharmacological strategies that reduce both viral…”
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Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt‐induced hypertension by Li, Yifang, Shen, Matthew, Ferens, Dorota, Broughton, Brad R.S., Murthi, Padma, Saini, Sheetal, Widdop, Robert E., Ricardo, Sharon D., Pinar, Anita A., Samuel, Chrishan S.

“…Background and Purpose Fibrosis is a hallmark of chronic kidney disease (CKD) that significantly contributes to renal dysfunction, and impairs the efficacy of…”
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A switch in N-terminal capping of β-peptides creates novel self-assembled nanoparticles by Chen, Yi-Kai, Simon, Isabella A, Maslov, Ivan, Oyarce-Pino, Ivan E, Kulkarni, Ketav, Hopper, Denham, Aguilar, Marie-Isabel, Vankadari, Naveen, Broughton, Brad RS, Del Borgo, Mark P

“…Small tripeptides composed entirely of β 3 -amino acids have been shown to self-assemble into fibres following acylation of the N-terminus. Given the use of…”
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Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide by Brait, Vanessa H, Jackman, Katherine A, Walduck, Anna K, Selemidis, Stavros, Diep, Henry, Mast, Anja E, Guida, Elizabeth, Broughton, Brad RS, Drummond, Grant R, Sobey, Christopher G

“…Cerebral infarct volume is typically smaller in premenopausal females than in age-matched males after ischemic stroke, but the underlying mechanisms are poorly…”
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Evidence of CCR2-Independent Transmigration of Ly6Chi Monocytes into the Brain after Permanent Cerebral Ischemia in Mice by Chu, Hannah X, Kim, Hyun Ah, Lee, Seyoung, Broughton, Brad R.S, Drummond, Grant R, Sobey, Christopher G

“…Abstract Previously we showed that INCB3344, a CCR2 antagonist, inhibits transmigration of Ly6Chi monocytes into the brain after ischemia-reperfusion. Here we…”
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Diet-induced vitamin D deficiency has no effect on acute post-stroke outcomes in young male mice by Evans, Megan A, Kim, Hyun Ah, De Silva, T Michael, Arumugam, Thiruma V, Clarkson, Andrew N, Drummond, Grant R, Zosky, Graeme R, Broughton, Brad RS, Sobey, Christopher G

“…Recent observational studies have reported that patients with low circulating levels of vitamin D experience larger infarct volumes and worse functional…”
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IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke by Zhang, Shenpeng R, Piepke, Marius, Chu, Hannah X, Broughton, Brad Rs, Shim, Raymond, Wong, Connie Hy, Lee, Seyoung, Evans, Megan A, Vinh, Antony, Sakkal, Samy, Arumugam, Thiruma V, Magnus, Tim, Huber, Samuel, Gelderblom, Mathias, Drummond, Grant R, Sobey, Christopher G, Kim, Hyun Ah

“…Stroke triggers a complex inflammatory process in which the balance between pro- and antiinflammatory mediators is critical for the development of the brain…”
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Chemokine-related gene expression in the brain following ischemic stroke: No role for CXCR2 in outcome by Brait, Vanessa H, Rivera, Jennifer, Broughton, Brad R.S, Lee, Seyoung, Drummond, Grant R, Sobey, Christopher G

“…Abstract This study sought to identify potential targets for acute stroke therapy that can be exploited pharmacologically beyond the current 4.5 h time limit…”
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Diffusive oxygen shunting between vessels in the preglomerular renal vasculature: anatomic observations and computational modeling by Gardiner, Bruce S, Thompson, Sarah L, Ngo, Jennifer P, Smith, David W, Abdelkader, Amany, Broughton, Brad R S, Bertram, John F, Evans, Roger G

“…To understand how geometric factors affect arterial-to-venous (AV) oxygen shunting, a mathematical model of diffusive oxygen transport in the renal cortex was…”
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Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease by Ding, Alice, Kalaignanasundaram, Priyadharshani, Ricardo, Sharon D, Abdelkader, Amany, Witting, Paul K, Broughton, Brad RS, Kim, Hyun B, Wyse, Benjamin F, Phillips, Jacqueline K, Evans, Roger G

“…Summary In the present study, we tested whether polycystic kidney disease (PKD) is associated with renal tissue hypoxia and oxidative stress, which, in turn,…”
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38 IS THE NOVEL G PROTEIN-COUPLED ESTROGEN RECEPTOR A SEX SPECIFIC TARGET FOLLOWING STROKE? by Broughton, Brad RS, Brait, Vanessa H, Lee, Seyoung, Guida, Elizabeth, Gardiner-Mann, Chantelle V, Miller, Alyson A, Arumugam, Thiruma V, Drummond, Grant R, Sobey, Christopher G

“…BACKGROUND:Experimental studies indicate that estrogen typically, but not universally, has a neuroprotective effect in stroke. Recent work from our laboratory…”
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Impaired NO-dependent inhibition of store- and receptor-operated calcium entry in pulmonary vascular smooth muscle after chronic hypoxia by Jernigan, Nikki L, Broughton, Brad R S, Walker, Benjimen R, Resta, Thomas C

“…We have recently demonstrated that chronic hypoxia (CH) attenuates nitric oxide (NO)-mediated decreases in pulmonary vascular smooth muscle (VSM) intracellular…”
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Dual mechanisms for nitric oxide control of large arteries in the estuarine crocodile Crocodylus porosus by Broughton, Brad R S, Donald, John A

“…In reptiles, accumulating evidence suggests that nitric oxide (NO) induces a potent relaxation in the systemic vasculature. However, very few studies have…”
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Nox1 Oxidase Suppresses Influenza A Virus-Induced Lung Inflammation and Oxidative Stress. e60792 by Selemidis, Stavros, Seow, Huei Jiunn, Broughton, Brad RS, Vinh, Antony, Bozinovski, Steven, Sobey, Christopher G, Drummond, Grant R, Vlahos, Ross

“…Influenza A virus infection is an ongoing clinical problem and thus, there is an urgent need to understand the mechanisms that regulate the lung inflammation…”
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Nitric oxide control of large veins in the toad Bufo marinus by Broughton, Brad R S, Donald, John A

“…This study examined the nitric oxide (NO) control of the vascular smooth muscle of the ventral abdominal vein and vena cava of the toad, Bufo marinus, by using…”
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