Search Results - "Brott, D"

Biomarkers of drug-induced vascular injury by Brott, D., Gould, S., Jones, H., Schofield, J., Prior, H., Valentin, J.P, Bjurstrom, S., Kenne, K., Schuppe-Koistinen, I., Katein, A., Foster-Brown, L., Betton, G., Richardson, R., Evans, G., Louden, C.

“…In pre-clinical safety studies, drug-induced vascular injury is an issue of concern because there are no obvious diagnostic markers for pre-clinical or…”
Get full text

Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours by Andreadis, S T, Brott, D, Fuller, A O, Palsson, B O

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Donor-to-donor variability in the expansion potential of human bone marrow cells is reduced by accessory cells but not by soluble growth factors by Koller, M R, Manchel, I, Brott, D A, Palsson Bø

“…Clinical trials assessing the utility of cultured hematopoietic cells for the support of patients receiving high-dose chemotherapy are beginning. Although many…”
Get more information

Current status and future directions for diagnostic markers of drug-induced vascular injury by Brott, D A, Jones, H B, Gould, S, Valentin, J P, Evans, G, Richardson, R J, Louden, C

“…Recently, there has been an increased incidence of vascular toxicity in pre-clinical toxicology studies. This is of concern because of the uncertain relevance…”
Get more information

Flow cytometric characterization of perfused human bone marrow cultures: Identification of the major cell lineages and correlation with the CFU‐GM assay by Brott, D. A., Maher, R. J., Parrish, C. R., Richardson, R. J., Smith, A. K.

“…Background Prolific cultures of human bone marrow mononuclear cells (BM MNCs) were recently developed that include a full spectrum of hematopoietic and…”
Get full text

Bacterial lipopolysaccharide, phorbol myristate acetate, and muramyl dipeptide stimulate the expression of a human monocyte surface antigen, Mo3e by Todd, RF, 3d, Alvarez, PA, Brott, DA, Liu, DY

“…Exposure of mononuclear phagocytes to bacterial lipopolysaccharide (LPS), phorbol myristate acetate (PMA), or muramyl dipeptide (MDP) is known to stimulate a…”
Get full text

Confocal laser scanning immunofluorescence imaging for quantitation of stromelysin in human synovial fibroblasts by Baragi, V M, Brott, D A, Qiu, L, Conroy, M C, Lalwani, N D

Get more information

Cell cycle dependent distribution of proliferating cell nuclear antigen/cyclin and cdc2-kinase in mouse T-lymphoma cells by Brott, D A, Alvey, J D, Bleavins, M R, de la Iglesia, F A, Lalwani, N D

“…The aim of the present study was to investigate bromodeoxyuridine (BrdU) uptake and coordinated distribution of proliferating cell nuclear antigen (PCNA) and…”
Get more information

Flow cytometric characterization of lymphocyte subpopulations in the cynomolgus monkey (Macaca fascicularis) by Bleavins, M R, Brott, D A, Alvey, J D, de la Iglesia, F A

“…Characterization of immune cell subpopulations in the cynomolgus monkey was performed using a direct immunofluorescence technique adaptable for routine and…”
Get more information

A systems biology approach for detecting toxicity-related hotspots inside protein interaction networks by Desai, Kaushal, Brott, David, Hu, Xiaohua, Christianson, Anastasia

“…Drug-induced neutropenia can be fatal when severe and therefore requires an improved understanding of its mechanism(s) of toxicity. Systems biology provides an…”
Get more information

Biomarkers and Mechanisms of Drug-Induced Vascular Injury in Non-Rodents by Louden, Calvert, Brott, David, Katein, Anne, Kelly, Thomas, Gould, Sarah, Jones, Huw, Betton, Graham, Valetin, Jean-Pierre, Richardson, Rudy J.

“…In preclinical safety studies, drug-induced vascular injury can negatively impact candidate-drug selection because there are no obvious diagnostic markers for…”
Get full text

Regulation of Human Monocyte Surface Antigen Expression. I. Up-Modulation of Mo3e Antigen Expression on U-937 and HL-60 Cells Stimulated by Pharmacologic Activators of Protein Kinase C by Todd, Robert F., Bury, Martin J., Alvarez, Patti A., Brott, David A., Liu, David Y.

“…Mo3e is a protein (p 50,80) that is expressed on the surface of human monocytic cells after exposure in vitro to soluble activating factors that include…”
Get full text

Are Laboratory Parameter (Biomarker) Values Similar to the Healthy Volunteer Reference Range in Individuals with Diabetes by Brott, David A, Goodman, Michael J, Hermann, Richard P, Anderson, Isobel, Kiazand, Alexandre

“…Identification of laboratory parameter clinical safety signals depends on the terminology and scoring criteria. Grade 1 scoring criteria in the Common…”
Get full text

Differential analysis of animal bone marrow by flow cytometry by Martin, Ronald A., Brott, David A., Zandee, Joyce C., McKeel, Mildred J.

“…A simple procedure was developed for rapid analysis of animal bone marrow by flow cytometry using the lipophilic cationic dye 3,3′‐dihexyloxacarbocyanine…”
Get full text

Characterization of renal biomarkers for use in clinical trials: biomarker evaluation in healthy volunteers by Brott, David A, Adler, Scott H, Arani, Ramin, Lovick, Susan C, Pinches, Mark, Furlong, Stephen T

“…Several preclinical urinary biomarkers have been qualified and accepted by the health authorities (US Food and Drug Administration, European Medicines Agency,…”
Get full text

Are laboratory parameter (biomarker) values similar to the healthy volunteer reference range in all patient populations? by Brott, David A, Goodman, Michael J, Hermann, Richard P, Merz, Michael, Calvo, Roser, Poorkhalkali, Nadereh, Kiazand, Alexandre

“…Liver biomarkers alanine aminotransferase (ALT) and bilirubin in patients with hepatitis are above the healthy volunteer reference range (HVRR) at baseline…”
Get full text

Characterization of renal biomarkers for use in clinical trials: effect of preanalytical processing and qualification using samples from subjects with diabetes by Brott, David A, Furlong, Stephen T, Adler, Scott H, Hainer, James W, Arani, Ramin B, Pinches, Mark, Rossing, Peter, Chaturvedi, Nish

“…Identifying the potential for drug-induced kidney injury is essential for the successful research and development of new drugs. Newer and more sensitive…”
Get full text

A Systems Biology Approach for Detecting Toxicity-Related Hotspots inside Protein Interaction Networks by Desai, K., Brott, D., Xiaohua Hu, Christianson, A.

“…Drug-induced Neutropenia can be fatal when severe and therefore requires an improved understanding of its mechanism(s) of toxicity. Systems biology provides an…”
Get full text

Immunofluorescence quantitation of stromelysin in human synovial fibroblasts by confocal laser scanning microscopy by Baragi, V M, Brott, D A, Qiu, L, Conroy, M C, Lalwani, N D

“…Elevated levels of stromelysin have been reported in humans with osteoarthritis and rheumatoid arthritis, as well as in animal models of arthritis. However, a…”
Get more information

Stress-Induced Cardiomyopathy Precipitated by COVID-19 and Influenza A Coinfection by Sang, Charlie Joseph, Heindl, Brittain, Von Mering, Gregory, Brott, Brigitta, Kopf, Robert S., Benson, Paul V., Rajapreyar, Indranee

“…Myocardial injury is associated with excess mortality in severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infections, but the mechanisms of injury…”
Get full text