Search Results - "Brost, Renee L."

The interaction network of the chaperonin CCT by Dekker, Carien, Stirling, Peter C, McCormack, Elizabeth A, Filmore, Heather, Paul, Angela, Brost, Renee L, Costanzo, Michael, Boone, Charles, Leroux, Michel R, Willison, Keith R

“…The eukaryotic cytosolic chaperonin containing TCP‐1 (CCT) has an important function in maintaining cellular homoeostasis by assisting the folding of many…”
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The DNA damage response pathway contributes to the stability of chromosome III derivatives lacking efficient replicators by Theis, James F, Irene, Carmela, Dershowitz, Ann, Brost, Renee L, Tobin, Michael L, di Sanzo, Fabiana M, Wang, Jian-Ying, Boone, Charles, Newlon, Carol S

“…In eukaryotic chromosomes, DNA replication initiates at multiple origins. Large inter-origin gaps arise when several adjacent origins fail to fire. Little is…”
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The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast by Tonkin, Louise M, Brost, Renée L, Menne, Tobias F, Warren, Alan J, Ancliff, Philip J, Costanzo, Michael, Sánchez-Puig, Nuria, Goyenechea, Beatriz, Boone, Charles, Wong, Chi C

“…The autosomal recessive disorder Shwachman-Diamond syndrome, characterized by bone marrow failure and leukemia predisposition, is caused by deficiency of the…”
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Genetic interactions of MAF1 identify a role for Med20 in transcriptional repression of ribosomal protein genes by Willis, Ian M, Chua, Gordon, Tong, Amy H, Brost, Renee L, Hughes, Timothy R, Boone, Charles, Moir, Robyn D

“…Transcriptional repression of ribosomal components and tRNAs is coordinately regulated in response to a wide variety of environmental stresses. Part of this…”
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Molecular Chaperone Hsp90 Stabilizes Pih1/Nop17 to Maintain R2TP Complex Activity That Regulates snoRNA Accumulation by Zhao, Rongmin, Kakihara, Yoshito, Gribun, Anna, Huen, Jennifer, Yang, Guocheng, Khanna, May, Costanzo, Michael, Brost, Renée L., Boone, Charles, Hughes, Timothy R., Yip, Christopher M., Houry, Walid A.

“…Hsp90 is a highly conserved molecular chaperone that is involved in modulating a multitude of cellular processes. In this study, we identify a function for the…”
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Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast by Parsons, Ainslie B., Lopez, Andres, Givoni, Inmar E., Williams, David E., Gray, Christopher A., Porter, Justin, Chua, Gordon, Sopko, Richelle, Brost, Renee L., Ho, Cheuk-Hei, Wang, Jiyi, Ketela, Troy, Brenner, Charles, Brill, Julie A., Fernandez, G. Esteban, Lorenz, Todd C., Payne, Gregory S., Ishihara, Satoru, Ohya, Yoshikazu, Andrews, Brenda, Hughes, Timothy R., Frey, Brendan J., Graham, Todd R., Andersen, Raymond J., Boone, Charles

“…Discovering target and off-target effects of specific compounds is critical to drug discovery and development. We generated a compendium of “chemical-genetic…”
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Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways by Brost, Renée L, Li, Zhijian, Hughes, Timothy R, Brown, Grant W, Ding, Huiming, Sheikh, Bilal, Parsons, Ainslie B, Kane, Patricia M, Zhang, Chaoying, Boone, Charles

“…Bioactive compounds can be valuable research tools and drug leads, but it is often difficult to identify their mechanism of action or cellular target. Here we…”
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Identification of a Bacterial Type III Effector Family with G Protein Mimicry Functions by Alto, Neal M., Shao, Feng, Lazar, Cheri S., Brost, Renee L., Chua, Gordon, Mattoo, Seema, McMahon, Stephen A., Ghosh, Partho, Hughes, Timothy R., Boone, Charles, Dixon, Jack E.

“…Many bacterial pathogens use the type III secretion system to inject “effector” proteins into host cells. Here, we report the identification of a 24 member…”
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Genetic and Biochemical Analysis of Yeast and Human Cap Trimethylguanosine Synthase: FUNCTIONAL OVERLAP OF 2,2,7-TRIMETHYLGUANOSINE CAPS, SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENTS, PRE-mRNA SPLICING FACTORS, AND RNA DECAY PATHWAYS by Hausmann, Stéphane, Zheng, Sushuang, Costanzo, Michael, Brost, Renee L, Garcin, Dominique, Boone, Charles, Shuman, Stewart, Schwer, Beate

“…Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m⁷G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal…”
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The synthetic genetic interaction spectrum of essential genes by Zhu, Hongwei, Boone, Charles, Andrews, Brenda J, Brost, Renée L, Mnaimneh, Sanie, Cheng, Xin, Haynes, Jennifer, Hughes, Timothy R, Yu, Lisa, Davierwala, Armaity P, Ding, Huiming, Li, Zhijian, Chen, Yiqun, Brown, Grant W, Robinson, Mark D

“…The nature of synthetic genetic interactions involving essential genes (those required for viability) has not been previously examined in a broad and unbiased…”
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Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast by Mousley, Carl J, Tyeryar, Kimberly, Ile, Kristina E, Schaaf, Gabriel, Brost, Renee L, Boone, Charles, Guan, Xueli, Wenk, Markus R, Bankaitis, Vytas A

“…Synthetic genetic array analyses identify powerful genetic interactions between a thermosensitive allele (sec14-1(ts)) of the structural gene for the major…”
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Genetic and Biochemical Analysis of Yeast and Human Cap Trimethylguanosine Synthase by Hausmann, Stéphane, Zheng, Sushuang, Costanzo, Michael, Brost, Renee L., Garcin, Dominique, Boone, Charles, Shuman, Stewart, Schwer, Beate

“…Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m7G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal…”
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Rex1p deficiency leads to accumulation of precursor initiator tRNAMet and polyadenylation of substrate RNAs in Saccharomyces cerevisiae by Ozanick, Sarah G, Wang, Xuying, Costanzo, Michael, Brost, Renee L, Boone, Charles, Anderson, James T

“…A synthetic genetic array was used to identify lethal and slow-growth phenotypes produced when a mutation in TRM6, which encodes a tRNA modification enzyme…”
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Genetic Landscape of a Cell by Costanzo, Michael, Baryshnikova, Anastasia, Bellay, Jeremy, Kim, Yungil, Spear, Eric D, Sevier, Carolyn S, Ding, Huiming, Koh, Judice L.Y, Toufighi, Kiana, Mostafavi, Sara, Prinz, Jeany, St. Onge, Robert P, VanderSluis, Benjamin, Makhnevych, Taras, Vizeacoumar, Franco J, Alizadeh, Solmaz, Bahr, Sondra, Brost, Renee L, Chen, Yiqun, Cokol, Murat, Deshpande, Raamesh, Li, Zhijian, Lin, Zhen-Yuan, Liang, Wendy, Marback, Michaela, Paw, Jadine, San Luis, Bryan-Joseph, Shuteriqi, Ermira, Tong, Amy Hin Yan, van Dyk, Nydia, Wallace, Iain M, Whitney, Joseph A, Weirauch, Matthew T, Zhong, Guoqing, Zhu, Hongwei, Houry, Walid A, Brudno, Michael, Ragibizadeh, Sasan, Papp, Balázs, Pál, Csaba, Roth, Frederick P, Giaever, Guri, Nislow, Corey, Troyanskaya, Olga G, Bussey, Howard, Bader, Gary D, Gingras, Anne-Claude, Morris, Quaid D, Kim, Philip M, Kaiser, Chris A, Myers, Chad L, Andrews, Brenda J, Boone, Charles

“…A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative…”
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Rex1p deficiency leads to accumulation of precursor initiator tRNA[sup]Met and polyadenylation of substrate RNAs in Saccharomyces cerevisiae by Ozanick, Sarah G, Wang, Xuying, Costanzo, Michael, Brost, Renee L, Boone, Charles, Anderson, James T

“…A synthetic genetic array was used to identify lethal and slow-growth phenotypes produced when a mutation in TRM6, which encodes a tRNA modification enzyme…”
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The DNA Damage Response Pathway Contributes to the Stability of Chromosome III Derivatives Lacking Efficient Replicators: e1001227 by Theis, James F, Irene, Carmela, Dershowitz, Ann, Brost, Renee L, Tobin, Michael L, Sanzo, Fabiana Mdi, Wang, Jian-Ying, Boone, Charles, Newlon, Carol S

“…In eukaryotic chromosomes, DNA replication initiates at multiple origins. Large inter-origin gaps arise when several adjacent origins fail to fire. Little is…”
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Genetic Interactions of MAF1 Identify a Role for Med20 in Transcriptional Repression of Ribosomal Protein Genes: e1000112 by Willis, Ian M, Chua, Gordon, Tong, Amy H, Brost, Renee L, Hughes, Timothy R, Boone, Charles, Moir, Robyn D

“…Transcriptional repression of ribosomal components and tRNAs is coordinately regulated in response to a wide variety of environmental stresses. Part of this…”
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