APOL1 Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans

Apolipoprotein L1 gene ( ) variants are risk factors for chronic kidney disease (CKD) among Black Americans. Data are sparse on the genetic epidemiology of CKD and the clinical association of variants with CKD in West Africans, a major group in the Black population. We conducted a case-control study...

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Published in:	The New England journal of medicine
Main Authors:	Gbadegesin, Rasheed A, Ulasi, Ifeoma, Ajayi, Samuel, Raji, Yemi, Olanrewaju, Timothy, Osafo, Charlotte, Ademola, Adebowale D, Asinobi, Adanze, Winkler, Cheryl A, Burke, David, Arogundade, Fatiu, Ekem, Ivy, Plange-Rhule, Jacob, Mamven, Manmak, Matekole, Michael, Amodu, Olukemi, Cooper, Richard, Antwi, Sampson, Adeyemo, Adebowale A, Ilori, Titilayo O, Adabayeri, Victoria, Nyarko, Alexander, Ghansah, Anita, Amira, Toyin, Solarin, Adaobi, Awobusuyi, Olugbenga, Kimmel, Paul L, Brosius, Frank Chip, Makusidi, Muhammad, Odenigbo, Uzoma, Kretzler, Matthias, Hodgin, Jeffrey B, Pollak, Martin R, Boima, Vincent, Freedman, Barry I, Palmer, Nicholette D, Collins, Bernard, Phadnis, Milind, Smith, Jill, Agwai, Celia I, Okoye, Ogochukwu, Abdu, Aliyu, Wilson, Jillian, Williams, Winfred, Salako, Babatunde L, Parekh, Rulan S, Tayo, Bamidele, Adu, Dwomoa, Ojo, Akinlolu
Format:	Journal Article
Language:	English
Published:	United States 26-10-2024
Online Access:	Get full text
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Summary:	Apolipoprotein L1 gene ( ) variants are risk factors for chronic kidney disease (CKD) among Black Americans. Data are sparse on the genetic epidemiology of CKD and the clinical association of variants with CKD in West Africans, a major group in the Black population. We conducted a case-control study involving participants from Ghana and Nigeria who had CKD stages 2 through 5, biopsy-proven glomerular disease, or no kidney disease. We analyzed the association of CKD with variants among participants with high-risk genotypes (two risk alleles) and those with low-risk genotypes (fewer than two risk alleles) by fitting logistic-regression models that controlled for covariates, including clinical site, age, and sex. Among 8355 participants (4712 with CKD stages 2 through 5, 866 with glomerular diseases, and 2777 with no kidney disease), the prevalence of monoallelic variants was 43.0% and that of biallelic variants was 29.7%. Participants with two risk alleles had higher odds of having CKD than those with one risk allele or no risk alleles (adjusted odds ratio, 1.25; 95% confidence interval [CI], 1.11 to 1.40), as well as higher odds of focal segmental glomerulosclerosis (adjusted odds ratio, 1.84; 95% CI, 1.30 to 2.61). Participants with one risk allele had higher odds of having CKD than those with no risk alleles (adjusted odds ratio, 1.18; 95% CI, 1.04 to 1.33), as well as higher odds of focal segmental glomerulosclerosis (adjusted odds ratio, 1.61; 95% CI, 1.04 to 2.48). The inclusion of covariates did not modify the association of monoallelic and biallelic variants with CKD or focal segmental glomerulosclerosis. In this study, monoallelic variants were associated with 18% higher odds of CKD and 61% higher odds of focal segmental glomerulosclerosis; biallelic variants were associated with 25% higher odds of CKD and 84% higher odds of focal segmental glomerulosclerosis. (Funded by the National Human Genome Research Institute and others.).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2404211