Search Results - "Brosens, Jan J"

Cyclic Decidualization of the Human Endometrium in Reproductive Health and Failure by Gellersen, Birgit, Brosens, Jan J

“…Decidualization denotes the transformation of endometrial stromal fibroblasts into specialized secretory decidual cells that provide a nutritive and…”
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Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss by Quenby, Siobhan, Gallos, Ioannis D, Dhillon-Smith, Rima K, Podesek, Marcelina, Stephenson, Mary D, Fisher, Joanne, Brosens, Jan J, Brewin, Jane, Ramhorst, Rosanna, Lucas, Emma S, McCoy, Rajiv C, Anderson, Robert, Daher, Shahd, Regan, Lesley, Al-Memar, Maya, Bourne, Tom, MacIntyre, David A, Rai, Raj, Christiansen, Ole B, Sugiura-Ogasawara, Mayumi, Odendaal, Joshua, Devall, Adam J, Bennett, Phillip R, Petrou, Stavros, Coomarasamy, Arri

“…Miscarriage is generally defined as the loss of a pregnancy before viability. An estimated 23 million miscarriages occur every year worldwide, translating to…”
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The mutational landscape of normal human endometrial epithelium by Moore, Luiza, Leongamornlert, Daniel, Coorens, Tim H. H., Sanders, Mathijs A., Ellis, Peter, Dentro, Stefan C., Dawson, Kevin J., Butler, Tim, Rahbari, Raheleh, Mitchell, Thomas J., Maura, Francesco, Nangalia, Jyoti, Tarpey, Patrick S., Brunner, Simon F., Lee-Six, Henry, Hooks, Yvette, Moody, Sarah, Mahbubani, Krishnaa T., Jimenez-Linan, Mercedes, Brosens, Jan J., Iacobuzio-Donahue, Christine A., Martincorena, Inigo, Saeb-Parsy, Kourosh, Campbell, Peter J., Stratton, Michael R.

“…All normal somatic cells are thought to acquire mutations, but understanding of the rates, patterns, causes and consequences of somatic mutations in normal…”
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Forkhead box proteins: tuning forks for transcriptional harmony by Lam, Eric W.-F., Brosens, Jan J., Gomes, Ana R., Koo, Chuay-Yeng

“…Key Points Forkhead box (FOX) proteins are a superfamily of transcriptional regulators that have a key role both during development and in adult tissue…”
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Human embryo implantation by Muter, Joanne, Lynch, Vincent J, McCoy, Rajiv C, Brosens, Jan J

“…Embryo implantation in humans is interstitial, meaning the entire conceptus embeds in the endometrium before the placental trophoblast invades beyond the…”
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Preeclampsia: the role of persistent endothelial cells in uteroplacental arteries by Brosens, Ivo, Brosens, Jan J., Muter, Joanne, Puttemans, Patrick, Benagiano, Giuseppe

“…We explore the potential role of the endothelial lining of uteroplacental arteries in the pathogenesis of preeclampsia, a severe pregnancy disorder…”
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The actions of resveratrol in decidualizing endometrium: acceleration or inhibition? by Kuroda, Keiji, Ochiai, Asako, Brosens, Jan J

“…Resveratrol, a natural polyphenolic compound, is widely studied for its anti-inflammatory and antisenescent properties. Recently, two studies reported…”
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Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids by Rawlings, Thomas M, Makwana, Komal, Taylor, Deborah M, Molè, Matteo A, Fishwick, Katherine J, Tryfonos, Maria, Odendaal, Joshua, Hawkes, Amelia, Zernicka-Goetz, Magdalena, Hartshorne, Geraldine M, Brosens, Jan J, Lucas, Emma S

“…Decidual remodelling of midluteal endometrium leads to a short implantation window after which the uterine mucosa either breaks down or is transformed into a…”
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The impact of uterine immaturity on obstetrical syndromes during adolescence by Brosens, Ivo, MD, PhD, Muter, Joanne, PhD, Gargett, Caroline, PhD, Puttemans, Patrick, MD, Benagiano, Giuseppe, MD, PhD, Brosens, Jan J., MD, PhD

“…Pregnant nulliparous adolescents are at increased risk, inversely proportional to their age, of major obstetric syndromes, including preeclampsia, fetal growth…”
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Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss by Salker, Madhuri, Teklenburg, Gijs, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J, Lokugamage, Amali U, Rai, Raj, Landles, Christian, Roelen, Bernard A J, Quenby, Siobhan, Kuijk, Ewart W, Kavelaars, Annemieke, Heijnen, Cobi J, Regan, Lesley, Macklon, Nick S, Brosens, Jan J

“…Recurrent pregnancy loss (RPL), defined as 3 or more consecutive miscarriages, is widely attributed either to repeated chromosomal instability in the conceptus…”
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New insights into the mechanisms underlying recurrent pregnancy loss by Ewington, Lauren J., Tewary, Shreeya, Brosens, Jan J.

“…Recurrent pregnancy loss (RPL), defined as multiple consecutive miscarriages, is a devastating disorder for which there are no good treatment options. Two…”
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Loss of Endometrial Plasticity in Recurrent Pregnancy Loss by Lucas, Emma S., Dyer, Nigel P., Murakami, Keisuke, Hou Lee, Yie, Chan, Yi‐Wah, Grimaldi, Giulia, Muter, Joanne, Brighton, Paul J., Moore, Jonathan D., Patel, Gnyaneshwari, Chan, Jerry K.Y., Takeda, Satoru, Lam, Eric W‐F., Quenby, Siobhan, Ott, Sascha, Brosens, Jan J.

“…Menstruation drives cyclic activation of endometrial progenitor cells, tissue regeneration, and maturation of stromal cells, which differentiate into…”
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Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation by Grewal, Karen, Lee, Yun S, Smith, Ann, Brosens, Jan J, Bourne, Tom, Al-Memar, Maya, Kundu, Samit, MacIntyre, David A, Bennett, Phillip R

“…Emerging evidence supports an association between vaginal microbiota composition and risk of miscarriage; however, the underlying mechanisms are poorly…”
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Composition, Development, and Function of Uterine Innate Lymphoid Cells by Doisne, Jean-Marc, Balmas, Elisa, Boulenouar, Selma, Gaynor, Louise M, Kieckbusch, Jens, Gardner, Lucy, Hawkes, Delia A, Barbara, Cynthia F, Sharkey, Andrew M, Brady, Hugh J M, Brosens, Jan J, Moffett, Ashley, Colucci, Francesco

“…Innate lymphoid cells (ILCs), including NK cells, contribute to barrier immunity and tissue homeostasis. In addition to the role of uterine NK cells in…”
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Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation by Teklenburg, Gijs, Salker, Madhuri, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J, Lokugamage, Amali U, Rai, Raj, Landles, Christian, Roelen, Bernard A J, Quenby, Siobhan, Kuijk, Ewart W, Kavelaars, Annemieke, Heijnen, Cobi J, Regan, Lesley, Brosens, Jan J, Macklon, Nick S

“…Pregnancy is widely viewed as dependent upon an intimate dialogue, mediated by locally secreted factors between a developmentally competent embryo and a…”
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Mechanisms of endometrial progesterone resistance by Al-Sabbagh, Marwa, Lam, Eric W.-F., Brosens, Jan J.

“…Throughout the reproductive years, the rise and fall in ovarian hormones elicit in the endometrium waves of cell proliferation, differentiation, recruitment of…”
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Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms by Sposini, Silvia, Jean-Alphonse, Frederic G., Ayoub, Mohammed A., Oqua, Affiong, West, Camilla, Lavery, Stuart, Brosens, Jan J., Reiter, Eric, Hanyaloglu, Aylin C.

“…Endocytic trafficking is a critical mechanism for cells to decode complex signaling pathways, including those activated by G-protein-coupled receptors (GPCRs)…”
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The role of FOXO1 in the decidual transformation of the endometrium and early pregnancy by Kajihara, Takeshi, Brosens, Jan J., Ishihara, Osamu

“…Successful pregnancy requires coordination of embryo development, decidualization of endometrium, and placenta formation. Decidualization denotes the…”
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Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis by Craciunas, Laurentiu, Gallos, Ioannis, Chu, Justin, Bourne, Tom, Quenby, Siobhan, Brosens, Jan J, Coomarasamy, Arri

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Uterine Selection of Human Embryos at Implantation by Brosens, Jan J., Salker, Madhuri S., Teklenburg, Gijs, Nautiyal, Jaya, Salter, Scarlett, Lucas, Emma S., Steel, Jennifer H., Christian, Mark, Chan, Yi-Wah, Boomsma, Carolien M., Moore, Jonathan D., Hartshorne, Geraldine M., Šućurović, Sandra, Mulac-Jericevic, Biserka, Heijnen, Cobi J., Quenby, Siobhan, Groot Koerkamp, Marian J., Holstege, Frank C. P., Shmygol, Anatoly, Macklon, Nick S.

“…Human embryos frequently harbor large-scale complex chromosomal errors that impede normal development. Affected embryos may fail to implant although many first…”
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