Search Results - "Brophy, P J"

Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis by Howell, O. W., Palser, A., Polito, A., Melrose, S., Zonta, B., Scheiermann, C., Vora, A. J., Brophy, P. J., Reynolds, R.

“…Saltatory conduction in the nervous system is enabled through the intimate association between the leading edge of the myelin sheath and the axonal membrane to…”
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An Oligodendrocyte Cell Adhesion Molecule at the Site of Assembly of the Paranodal Axo-Glial Junction by Tait, Steven, Gunn-Moore, Frank, Collinson, J. Martin, Huang, Jeffery, Lubetzki, Catherine, Pedraza, Liliana, Sherman, Diane L., Colman, David R., Brophy, Peter J.

“…Two major isoforms of the cell adhesion molecule neurofascin NF186 and NF155 are expressed in the central nervous system (CNS). We have investigated their…”
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Charcot-Marie-Tooth type 4F disease caused by S399fsx410 mutation in the PRX gene by KABZINSKA, D, DRAC, H, SHERMAN, D. L, KOSTERA-PRUSZCZYK, A, BROPHY, P. J, KOCHANSKI, A, HAUSMANOWA-PETRUSEWICZ, I

“…Charcot-Marie-Tooth type 4F disease (CMT4F) is an autosomal recessive neuropathy caused by mutations in the PRX gene. To date, only seven mutations have been…”
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Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction by Roche, Sarah L, Sherman, Diane L, Dissanayake, Kosala, Soucy, Geneviève, Desmazieres, Anne, Lamont, Douglas J, Peles, Elior, Julien, Jean-Pierre, Wishart, Thomas M, Ribchester, Richard R, Brophy, Peter J, Gillingwater, Thomas H

“…Postnatal synapse elimination plays a critical role in sculpting and refining neural connectivity throughout the central and peripheral nervous systems,…”
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Role for the oligodendrocyte cytoskeleton in myelination by Wilson, R, Brophy, P J

“…Enriched cultures of rat brain oligodendrocytes were extracted with a buffer that separated the cells into a Triton X-100-soluble fraction and an insoluble…”
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Novel E-Cadherin-Mediated Adhesion in Peripheral Nerve: Schwann Cell Architecture Is Stabilized by Autotypic Adherens Junctions by Fannon, Allison M., Sherman, Diane L., Ilyina-Gragerova, Galina, Brophy, Peter J., Friedrich, Victor L., Colman, David R.

“…Previous studies (Blank, W. F., M. B. Bunge, and R. P. Bunge. 1974. Brain Res. 67:503-518) showed that Schwann cell paranodal membranes were disrupted in…”
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Microtubule-associated protein MAP1B expression precedes the morphological differentiation of oligodendrocytes by Vouyiouklis, D A, Brophy, P J

“…The microtubule-associated protein MAP1B is believed to play an important role in the outgrowth of neurites from neurons (Tucker and Matus, Dev Biol 130:…”
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The distribution of myelin basic protein mRNAs within myelinating oligodendrocytes by Brophy, P J, Boccaccio, G L, Colman, D R

“…The nervous system contains oligodendrocytes with processes that are greatly extended in space. It is now clear that there are numerous complex, poorly…”
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A Novel Gelsolin Isoform Expressed by Oligodendrocytes in the Central Nervous System by Vouyiouklis, Demetrius A., Brophy, Peter J.

“…: Two isoforms of the Ca2+‐sensitive, actin‐binding protein gelsolin have been identified thus far; one is an intracellular protein, cytoplasmic gelsolin, and…”
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Microtubule-associated proteins in developing oligodendrocytes: transient expression of a MAP2c isoform in oligodendrocyte precursors by Vouyiouklis, D A, Brophy, P J

“…The morphological differentiation of oligodendrocytes is characterized by the formation of multiple, microtubule-rich processes which endow these cells with…”
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A Novel Rat Tetraspan Protein in Cells of the Oligodendrocyte Lineage by Birling, Marie‐Christine, Tait, Steven, Hardy, Rebecca J., Brophy, Peter J.

“…: The tetraspanin/transmembrane 4 superfamily gene superfamily encodes proteins that span the plasma membrane four times. Tetraspan proteins are implicated in…”
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Transient expression of neurofascin by oligodendrocytes at the onset of myelinogenesis: Implications for mechanisms of axon-glial interaction by Collinson, J. Martin, Marshall, Daina, Gillespie, C. Stewart, Brophy, Peter J.

“…Cell adhesion molecules (CAMs) must play a crucial role in both the initiation and signalling of axon‐glial contact. However, the proteins that permit…”
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Neurofascin Is a Glial Receptor for the Paranodin/Caspr-Contactin Axonal Complex at the Axoglial Junction by Charles, Perrine, Tait, Steven, Faivre-Sarrailh, Catherine, Barbin, Gilles, Gunn-Moore, Frank, Denisenko-Nehrbass, Natalia, Guennoc, Anne-Marie, Girault, Jean-Antoine, Brophy, Peter J., Lubetzki, Catherine

“…In myelinated fibers of the vertebrate nervous system, glial-ensheathing cells interact with axons at specialized adhesive junctions, the paranodal…”
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Unique Role of Dystroglycan in Peripheral Nerve Myelination, Nodal Structure, and Sodium Channel Stabilization by Saito, Fumiaki, Moore, Steven A, Barresi, Rita, Henry, Michael D, Messing, Albee, Ross-Barta, Susan E, Cohn, Ronald D, Williamson, Roger A, Sluka, Kathleen A, Sherman, Diane L, Brophy, Peter J, Schmelzer, James D, Low, Phillip A, Wrabetz, Lawrence, Feltri, M.Laura, Campbell, Kevin P

“…Dystroglycan is a central component of the dystrophin-glycoprotein complex implicated in the pathogenesis of several neuromuscular diseases. Although…”
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Exchange rates at the lipid-protein interface of the myelin proteolipid protein determined by saturation transfer electron spin resonance and continuous wave saturation studies by Horváth, L.I., Brophy, P.J., Marsh, D.

“…The microwave saturation properties of various spin-labeled lipids in reconstituted complexes of the myelin proteolipid protein with dimyristoyl…”
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Schwann Cells of the Myelin-Forming Phenotype Express Neurofilament Protein NF-M by Kelly, Bernadette M., Gillespie, C. Stewart, Sherman, Diane L., Brophy, Peter J.

“…Immature Schwann cells of the rat sciatic nerve can differentiate into myelin-forming or non-myelin-forming cells. The factors that influence this divergent…”
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Specific Disruption of a Schwann Cell Dystrophin-Related Protein Complex in a Demyelinating Neuropathy by Sherman, Diane L, Fabrizi, Cinzia, Gillespie, C.Stewart, Brophy, Peter J

“…Dystroglycan-dystrophin complexes are believed to have structural and signaling functions by linking extracellular matrix proteins to the cytoskeleton and…”
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Focal Lysolecithin-Induced Demyelination of Peripheral Afferents Results in Neuropathic Pain Behavior That Is Attenuated by Cannabinoids by Wallace, Victoria C. J, Cottrell, David F, Brophy, Peter J, Fleetwood-Walker, Susan M

“…Demyelinating diseases can be associated with painful sensory phenomena such as tactile allodynia and hyperalgesia. To study the mechanisms underlying…”
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Rumpshaker: an X-linked mutation causing hypomyelination: developmental differences in myelination and glial cells between the optic nerve and spinal cord by Fanarraga, M L, Griffiths, I R, McCulloch, M C, Barrie, J A, Kennedy, P G, Brophy, P J

“…The X-linked mutation rumpshaker (rsh), which is probably an allele of jimpy (jp), causes hypomyelination in the CNS of mice. This study examines the…”
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A mutation in periaxin is responsible for CMT4F, an autosomal recessive form of Charcot-Marie-Tooth disease by GUILBOT, Angèle, WILLIAMS, Anna, MEGARBANE, André, CLAUSTRES, Mireille, RAVISE, Nicole, VERNY, Christophe, BRICE, Alexis, SHERMAN, Diane L, BROPHY, Peter J, LEGUERN, Eric, DELAGUE, Valérie, BAREIL, Corinne

“…Charcot-Marie-Tooth (CMT) disease is a heterogeneous group of inherited peripheral motor and sensory neuropathies characterized by chronic distal weakness with…”
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