Search Results - "Broom, Daniel C."

Blocking Caspase Activity Prevents Transsynaptic Neuronal Apoptosis and the Loss of Inhibition in Lamina II of the Dorsal Horn after Peripheral Nerve Injury by Scholz, Joachim, Broom, Daniel C, Youn, Dong-Ho, Mills, Charles D, Kohno, Tatsuro, Suter, Marc R, Moore, Kimberly A, Decosterd, Isabelle, Coggeshall, Richard E, Woolf, Clifford J

“…We show that transsynaptic apoptosis is induced in the superficial dorsal horn (laminas I-III) of the spinal cord by three distinct partial peripheral nerve…”
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Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion by Amaya, Fumimasa, Samad, Tarek A., Barrett, Lee, Broom, Daniel C., Woolf, Clifford J.

“…We have developed a model in which inflammation contiguous to and within a dorsal root ganglion (DRG) was generated by local application of complete Freund’s…”
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Detection of Cold Pain, Cold Allodynia and Cold Hyperalgesia in Freely Behaving Rats by Allchorne, Andrew J, Broom, Daniel C, Woolf, Clifford J

“…Background: Pain is elicited by cold, and a major feature of many neuropathic pain states is that normally innocuous cool stimuli begin to produce pain (cold…”
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Inflammation-induced reduction of spontaneous activity by adjuvant: A novel model to study the effect of analgesics in rats by Matson, David J, Broom, Daniel C, Carson, Susan R, Baldassari, James, Kehne, John, Cortright, Daniel N

“…The majority of rodent models used to evaluate analgesic drug effects rely on evoked measures of nociceptive thresholds as primary outcomes. These approaches…”
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Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation by Broom, Daniel C, Matson, David J, Bradshaw, Elizabeth, Buck, Marianne E, Meade, Robin, Coombs, Susan, Matchett, Michele, Ford, Kristen K, Yu, Weifeng, Yuan, Jun, Sun, Synthia H, Ochoa, Ricardo, Krause, James E, Wustrow, David J, Cortright, Daniel N

“…Recent evidence suggests that the P2X(7) receptor may play a role in the pathophysiology of preclinical models of pain and inflammation. Therefore,…”
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TRP channels and pain by Cortright, Daniel N., Krause, James E., Broom, Daniel C.

“…Since the molecular identification of the capsaicin receptor, now known as TRPV1, transient receptor potential (TRP) channels have occupied an important place…”
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Runx1 Determines Nociceptive Sensory Neuron Phenotype and Is Required for Thermal and Neuropathic Pain by Chen, Chih-Li, Broom, Daniel C., Liu, Yang, de Nooij, Joriene C., Li, Zhe, Cen, Chuan, Samad, Omar Abdel, Jessell, Thomas M., Woolf, Clifford J., Ma, Qiufu

“…In mammals, the perception of pain is initiated by the transduction of noxious stimuli through specialized ion channels and receptors expressed by nociceptive…”
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Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain by Bree, Dara, Moriarty, Orla, O'Mahony, Cliona M, Morris, Bradley, Bannerton, Karen, Broom, Daniel C, Kelly, John P, Roche, Michelle, Finn, David P

“…Acute postoperative pain remains a significant health care issue. Development of anatomically relevant animal models of postoperative pain, with improved…”
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Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain by Bree, Dara, Moriarty, Orla, Broom, Daniel C., Kelly, John P., Roche, Michelle, Finn, David P.

“…Summary Aims Acute postoperative pain remains a significant healthcare issue. Historically, the assessment of postoperative pain in rodents has relied on…”
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Nonpeptidic δ-opioid Receptor Agonists Reduce Immobility in the Forced Swim Assay in Rats by Broom, Daniel C, Jutkiewicz, Emily M, Folk, John E, Traynor, John R, Rice, Kenner C, Woods, James H

“…The present study examined the effect of opioid receptor agonists in the rat forced swim assay. The δ-opioid receptor agonists SNC80…”
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Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy by McCampbell, Alexander, Truong, David, Broom, Daniel C., Allchorne, Andrew, Gable, Ken, Cutler, Roy G., Mattson, Mark P., Woolf, Clifford J., Frosch, Matthew P., Harmon, Jeffrey M., Dunn, Teresa M., Brown, Robert H.

“…Mutations in enzymes involved in sphingolipid metabolism and trafficking cause a variety of neurological disorders, but details of the molecular…”
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Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice by Broom, Daniel C, Nitsche, Joshua F, Pintar, John E, Rice, Kenner C, Woods, James H, Traynor, John R

“…Delta-opioid receptor-selective agonists produce antinociception and convulsions in several species, including mice. This article examines two hypotheses in…”
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Convulsant activity of a non-peptidic δ-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats by BROOM, Daniel C, JUTKIEWICZ, Emily M, FOLK, John E, TRAYNOR, John R, RICE, Kenner C, WOODS, James H

“…Non-peptidic delta-opioid receptor agonists possess antidepressant-like activity in the forced swim assay in the rat. These compounds have also previously been…”
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Locomotor activity in a novel environment as a test of inflammatory pain in rats by Matson, David J, Broom, Daniel C, Cortright, Daniel N

“…Creating a robust and unbiased assay for the study of current and novel analgesics has been a daunting task. Traditional rodent models of pain and inflammation…”
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Behavioral Effects of δ-Opioid Receptor Agonists: Potential Antidepressants? by Broom, Daniel C., Jutkiewicz, Emily M., Rice, Kenner C., Traynor, John R., Woods, James H.

“…The development of selective δ-opioid receptor agonists has revealed some very intriguing behavioral properties. δ-Opioid agonists have antinociceptive,…”
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Behavioral Effects of d-Opioid Receptor Agonists: Potential Antidepressants? by Broom, Daniel C., Jutkiewicz, Emily M., Rice, Kenner C., Traynor, John R., Woods, James H.

“…The development of selective δ-opioid receptor agonists has revealed some very intriguing behavioral properties. δ-Opioid agonists have antinociceptive,…”
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Convulsant activity of a non-peptidic δ-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats by Broom, Daniel C, Jutkiewicz, Emily M, Folk, John E, Traynor, John R, Rice, Kenner C, Woods, James H

“…Abstract Rationale. Non-peptidic δ-opioid receptor agonists possess antidepressant-like activity in the forced swim assay in the rat. These compounds have also…”
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Nonpeptidic [delta]-opioid Receptor Agonists Reduce Immobility in the Forced Swim Assay in Rats by Broom, Daniel C, Jutkiewicz, Emily M, Folk, John E, Traynor, John R, Rice, Kenner C, Woods, James H

“…The present study examined the effect of opioid receptor agonists in the rat forced swim assay. The delta-opioid receptor agonists SNC80 ((+)-4-[(alpha…”
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