Search Results - "Brooks, W. D. W."

Tunable cavity optomechanics with ultracold atoms by Purdy, T P, Brooks, D W C, Botter, T, Brahms, N, Ma, Z-Y, Stamper-Kurn, D M

“…We present an atom-chip-based realization of quantum cavity optomechanics with cold atoms localized within a Fabry-Perot cavity. Effective subwavelength…”
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5-lipoxygenase inhibitory activity of zileuton by Carter, G W, Young, P R, Albert, D H, Bouska, J, Dyer, R, Bell, R L, Summers, J B, Brooks, D W

“…Zileuton [N-(1-benzo[b]thien-2-ylethyl)-N-hydroxyure] inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic leukemia cell 20,000 x g supernatant…”
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Optimization of the potency and duration of action of N-hydroxyurea 5-lipoxygenase inhibitors by Bell, R L, Bouska, J B, Malo, P E, Lanni, C, Harris, R R, Otis, E R, Stewart, A O, Brooks, D W, Carter, G W

“…As in vitro glucuronidation assay and several biochemical assays were utilized to discover potent new N-hydroxyurea-containing 5-lipoxygenase inhibitors with…”
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Nonsteroidal Anti-Inflammatory Drugs as Scaffolds for the Design of 5-Lipoxygenase Inhibitors by Kolasa, Teodozyj, Brooks, Clint D. W, Rodriques, Karen E, Summers, James B, Dellaria, Joseph F, Hulkower, Keren I, Bouska, Jennifer, Bell, Randy L, Carter, George W

“…Representative nonsteroidal anti-inflammatory drug (NSAID) cyclooxygenase inhibitors such as ibuprofen, naproxen, and indomethacin were used as orally…”
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The discovery and development of zileuton: an orally active 5-lipoxygenase inhibitor by Bell, R L, Young, P R, Albert, D, Lanni, C, Summers, J B, Brooks, D W, Rubin, P, Carter, G W

“…The enzyme 5-lipoxygenase is a key target in the effort to discover drugs which inhibit the pathophysiology associated with the formation of leukotrienes. The…”
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Symmetrical Bis(heteroarylmethoxyphenyl)alkylcarboxylic Acids as Inhibitors of Leukotriene Biosynthesis by Kolasa, Teodozyj, Gunn, David E, Bhatia, Pramila, Basha, Anwer, Craig, Richard A, Stewart, Andrew O, Bouska, Jennifer B, Harris, Richard R, Hulkower, Keren I, Malo, Peter E, Bell, Randy L, Carter, George W, Brooks, Clint D. W

“…Symmetrical bis(quinolylmethoxyphenyl)alkylcarboxylic acids were investigated as inhibitors of leukotriene biosynthesis and…”
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Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic Acids as Leukotriene Biosynthesis Inhibitors by Kolasa, Teodozyj, Gunn, David E, Bhatia, Pramila, Woods, Keith W, Gane, Todd, Stewart, Andrew O, Bouska, Jennifer B, Harris, Richard R, Hulkower, Keren I, Malo, Peter E, Bell, Randy L, Carter, George W, Brooks, Clint D. W

“…A novel series of heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids was studied as leukotriene biosynthesis inhibitors. A hypothesis of…”
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Preclinical and clinical activity of zileuton and A-78773 by Bell, R L, Lanni, C, Malo, P E, Brooks, D W, Stewart, A O, Hansen, R, Rubin, P, Carter, G W

“…The importance of leukotrienes as mediators of inflammation and bronchoconstriction was examined with two recently described 5-lipoxygenase inhibitors,…”
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4-Hydroxythiazole inhibitors of 5-lipoxygenase by Kerdesky, Francis A. J, Holms, James H, Moore, Jimmie L, Bell, Randy L, Dyer, Richard D, Carter, George W, Brooks, Dee W

“…4-Hydroxythiazoles have been identified as potent inhibitors of 5-lipoxygenase in vitro exhibiting IC50's of less than 1 microM. An investigation of…”
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Quantitative structure-activity relationships of 5-lipoxygenase inhibitors. Inhibitory potency of pyridazinone analogues by Kim, K H, Martin, Y C, Brooks, D W, Dyer, R D, Carter, G W

“…Quantitative structure-activity relationships (QSAR) of 72 1-phenyltetrahydropyridazin-3(2H)-one (I) analogues are examined for the inhibitory potency (IC50)…”
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Clinical activity of leukotriene inhibitors by Harris, Richard R., Carter, George W., Bell, Randy L., Moore, Jimmie L., Brooks, Dee W.

“…Data from the emerging clinical trials with compounds such as zileuton, ICI 204,219, Bay X1005, MK571, MK679, and MK591 are demonstrating the importance of the…”
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Inhibition of leukotriene biosynthesis in the rat peritoneal cavity by Young, P R, Bell, R L, Lanni, C, Summers, J B, Brooks, D W, Carter, G W

“…In the search for a model of leukotriene (LT) production to provide a method to determine in vivo 5-lipoxygenase (5-LO) inhibitory activity by various…”
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Orally active hydroxamic acid inhibitors of leukotriene biosynthesis by Summers, James B, Gunn, Bruce P, Martin, Jonathan G, Mazdiyasni, Hormoz, Stewart, Andrew O, Young, Patrick R, Goetze, Andrew M, Bouska, Jennifer B, Dyer, Richard D

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5-Lipoxygenase Inhibitors:  Synthesis and Structure−Activity Relationships of a Series of 1-Aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones by Bhatia, Pramila A, Brooks, Clint D. W, Basha, Anwer, Ratajczyk, James D, Gunn, Bruce P, Bouska, Jennifer B, Lanni, Carmine, Young, Patrick R, Bell, Randy L, Carter, George W

“…Synthetic routes were developed to access a variety of novel 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-one analogs which were evaluated as 5-lipoxygenase (5-LO)…”
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Second generation leukotriene biosynthesis inhibitors by Basha, A., Brooks, D. W., Stewart, A. O., Bell, R. L., Carter, G. W.

“…Abstract…”
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Autotomography of the upper dorsal region by Brooks, Jr, D W

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Modulators of Leukotriene Biosynthesis and Receptor Activation by Brooks, Clint D. W, Summers, James B

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The properties of A-69412: a small hydrophilic 5-lipoxygenase inhibitor by Bell, R L, Bouska, J, Young, P R, Lanni, C, Machinist, J, Malo, P E, Summers, J B, Brooks, D W, Carter, G W

“…A compound which inhibits leukotriene biosynthesis could be clinically useful in treating several allergic and inflammatory diseases. One site for such…”
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N,O-Bis(phenoxycarbonyl)hydroxylamine: a new reagent for the direct synthesis of substituted N-hydroxyureas by Stewart, Andrew O, Brooks, Dee W

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Time and Teaching by Zielinski, Theresa Julia, Brooks, David W, Crippen, Kent J, March, Joe L

“…Time management is an important issue for teachers and students. This article discusses teachers' use of time from the perspective of curriculum and…”
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