Search Results - "Brooks, Stephen R."

Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality by Shih, Han-Yu, Sciumè, Giuseppe, Mikami, Yohei, Guo, Liying, Sun, Hong-Wei, Brooks, Stephen R., Urban, Joseph F., Davis, Fred P., Kanno, Yuka, O’Shea, John J.

“…Innate lymphoid cells (ILCs) play key roles in host defense, barrier integrity, and homeostasis and mirror adaptive CD4+ T helper (Th) cell subtypes in both…”
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Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing by Sawaya, Andrew P., Stone, Rivka C., Brooks, Stephen R., Pastar, Irena, Jozic, Ivan, Hasneen, Kowser, O’Neill, Katelyn, Mehdizadeh, Spencer, Head, Cheyanne R., Strbo, Natasa, Morasso, Maria I., Tomic-Canic, Marjana

“…Diabetic foot ulcers (DFUs) are a life-threatening disease that often result in lower limb amputations and a shortened lifespan. However, molecular mechanisms…”
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Effects of HLA–B27 on Gut Microbiota in Experimental Spondyloarthritis Implicate an Ecological Model of Dysbiosis by Gill, Tejpal, Asquith, Mark, Brooks, Stephen R., Rosenbaum, James T., Colbert, Robert A.

“…Objective To investigate whether HLA–B27–mediated experimental spondyloarthritis (SpA) is associated with a common gut microbial signature, in order to…”
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Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity by Hirahara, Kiyoshi, Onodera, Atsushi, Villarino, Alejandro V., Bonelli, Michael, Sciumè, Giuseppe, Laurence, Arian, Sun, Hong-Wei, Brooks, Stephen R., Vahedi, Golnaz, Shih, Han-Yu, Gutierrez-Cruz, Gustavo, Iwata, Shigeru, Suzuki, Ryo, Mikami, Yohei, Okamoto, Yoshitaka, Nakayama, Toshinori, Holland, Steven M., Hunter, Christopher A., Kanno, Yuka, O’Shea, John J.

“…Interleukin-6 (IL-6) and IL-27 signal through a shared receptor subunit and employ the same downstream STAT transcription proteins, but yet are ascribed unique…”
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Transcriptional signature primes human oral mucosa for rapid wound healing by Iglesias-Bartolome, Ramiro, Uchiyama, Akihiko, Molinolo, Alfredo A, Abusleme, Loreto, Brooks, Stephen R, Callejas-Valera, Juan Luis, Edwards, Dean, Doci, Colleen, Asselin-Labat, Marie-Liesse, Onaitis, Mark W, Moutsopoulos, Niki M, Gutkind, J S, Morasso, Maria I

“…Oral mucosal wound healing has long been regarded as an ideal system of wound resolution. However, the intrinsic characteristics that mediate optimal healing…”
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Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction by Furumoto, Yasuko, Smith, Carolyne K., Blanco, Luz, Zhao, Wenpu, Brooks, Stephen R., Thacker, Seth G., Zarzour, Abdalrahman, Sciumè, Giuseppe, Tsai, Wanxia L., Trier, Anna M., Nunez, Leti, Mast, Laurel, Hoffmann, Victoria, Remaley, Alan T., O'Shea, John J., Kaplan, Mariana J., Gadina, Massimo

“…Objective Dysregulation of innate and adaptive immune responses contributes to the pathogenesis of systemic lupus erythematosus (SLE) and its associated…”
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Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis by Deniset, Justin F., Belke, Darrell, Lee, Woo-Yong, Jorch, Selina K., Deppermann, Carsten, Hassanabad, Ali Fatehi, Turnbull, Jeannine D., Teng, Guoqi, Rozich, Isaiah, Hudspeth, Kelly, Kanno, Yuka, Brooks, Stephen R., Hadjantonakis, Anna-Katerina, O’Shea, John J., Weber, Georg F., Fedak, Paul W.M., Kubes, Paul

“…Macrophages play an important role in structural cardiac remodeling and the transition to heart failure following myocardial infarction (MI). Previous research…”
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Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients by Kim, Hanna, Brooks, Kristina M., Tang, Cheng Cai, Wakim, Paul, Blake, Mary, Brooks, Stephen R., Montealegre Sanchez, Gina A., de Jesus, Adriana A., Huang, Yan, Tsai, Wanxia Li, Gadina, Massimo, Prakash, Apurva, Janes, Jonathan Marcus, Zhang, Xin, Macias, William L., Kumar, Parag, Goldbach‐Mansky, Raphaela

“…Population pharmacokinetic (popPK) modeling was used to characterize the PK profile of the oral Janus kinase (JAK)1/JAK2 inhibitor, baricitinib, in 18 patients…”
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The skin transcriptome in hidradenitis suppurativa uncovers an antimicrobial and sweat gland gene signature which has distinct overlap with wounded skin by Coates, Margaret, Mariottoni, Paula, Corcoran, David L, Kirshner, Hélène Fradin, Jaleel, Tarannum, Brown, David A, Brooks, Stephen R, Murray, John, Morasso, Maria I, MacLeod, Amanda S

“…Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease resulting in non-healing wounds affecting body areas of high hair follicle…”
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Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis by Carmona-Rivera, Carmelo, Carlucci, Philip M, Goel, Rishi R, James, Eddie, Brooks, Stephen R, Rims, Cliff, Hoffmann, Victoria, Fox, David A, Buckner, Jane H, Kaplan, Mariana J

“…Rheumatoid arthritis (RA) is characterized by synovial joint inflammation, cartilage damage, and dysregulation of the adaptive immune system. While neutrophil…”
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MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23 by Mikami, Yohei, Philips, Rachael L., Sciumè, Giuseppe, Petermann, Franziska, Meylan, Françoise, Nagashima, Hiroyuki, Yao, Chen, Davis, Fred P., Brooks, Stephen R., Sun, Hong-Wei, Takahashi, Hayato, Poholek, Amanda C., Shih, Han-Yu, Afzali, Behdad, Muljo, Stefan A., Hafner, Markus, Kanno, Yuka, O’Shea, John J.

“…MicroRNAs are important regulators of immune responses. Here, we show miR-221 and miR-222 modulate the intestinal Th17 cell response. Expression of miR-221 and…”
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CD271 activation prevents low to high-risk progression of cutaneous squamous cell carcinoma and improves therapy outcomes by Quadri, Marika, Tiso, Natascia, Musmeci, Francesco, Morasso, Maria I, Brooks, Stephen R, Bonetti, Luca Reggiani, Panini, Rossana, Lotti, Roberta, Marconi, Alessandra, Pincelli, Carlo, Palazzo, Elisabetta

“…Cutaneous squamous cell carcinoma (cSCC) is the second most prevalent form of skin cancer, showing a rapid increasing incidence worldwide. Although most cSCC…”
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Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling by Geiger, Sarah S., Traba, Javier, Richoz, Nathan, Farley, Taylor K., Brooks, Stephen R., Petermann, Franziska, Wang, Lingdi, Gonzalez, Frank J., Sack, Michael N., Siegel, Richard M.

“…In mice, time of day strongly influences lethality in response to LPS, with survival greatest at the beginning compared to the end of the light cycle. Here we…”
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Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells by Sciumè, Giuseppe, Mikami, Yohei, Jankovic, Dragana, Nagashima, Hiroyuki, Villarino, Alejandro V., Morrison, Tasha, Yao, Chen, Signorella, Sadie, Sun, Hong-Wei, Brooks, Stephen R., Fang, Difeng, Sartorelli, Vittorio, Nakayamada, Shingo, Hirahara, Kiyoshi, Zitti, Beatrice, Davis, Fred P., Kanno, Yuka, O’Shea, John J., Shih, Han-Yu

“…Innate immune responses rely on rapid and precise gene regulation mediated by accessibility of regulatory regions to transcription factors (TFs). In natural…”
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CHOP-mediated IL-23 overexpression does not drive colitis in experimental spondyloarthritis by Navid, Fatemeh, Gill, Tejpal, Fones, Lilah, Allbritton-King, Jules D., Zhou, Kelly, Shen, Isabel, Van Doorn, Jinny, LiCausi, Francesca, Cougnoux, Antony, Randazzo, Davide, Brooks, Stephen R., Colbert, Robert A.

“…HLA-B27 is a major risk factor for spondyloarthritis (SpA), yet the underlying mechanisms remain unclear. HLA-B27 misfolding-induced IL-23, which is mediated…”
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Genetically programmed alternative splicing of NEMO mediates an autoinflammatory disease phenotype by Lee, Younglang, Wessel, Alex W, Xu, Jiazhi, Reinke, Julia G, Lee, Eries, Kim, Somin M, Hsu, Amy P, Zilberman-Rudenko, Jevgenia, Cao, Sha, Enos, Clinton, Brooks, Stephen R, Deng, Zuoming, Lin, Bin, de Jesus, Adriana A, Hupalo, Daniel N, Piotto, Daniela Gp, Terreri, Maria T, Dimitriades, Victoria R, Dalgard, Clifton L, Holland, Steven M, Goldbach-Mansky, Raphaela, Siegel, Richard M, Hanson, Eric P

“…Host defense and inflammation are regulated by the NF-κB essential modulator (NEMO), a scaffolding protein with a broad immune cell and tissue expression…”
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Inactivating Mutation in IRF8 Promotes Osteoclast Transcriptional Programs and Increases Susceptibility to Tooth Root Resorption by Thumbigere‐Math, Vivek, Foster, Brian L, Bachu, Mahesh, Yoshii, Hiroaki, Brooks, Stephen R., Coulter, Alyssa, Chavez, Michael B, Togi, Sumihito, Neely, Anthony L, Deng, Zuoming, Mansky, Kim C, Ozato, Keiko, Somerman, Martha J

“…ABSTRACT This is the first study to our knowledge to report a novel mutation in the interferon regulatory factor 8 gene (IRF8G388S) associated with multiple…”
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Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions by Villarino, Alejandro, Laurence, Arian, Robinson, Gertraud W, Bonelli, Michael, Dema, Barbara, Afzali, Behdad, Shih, Han-Yu, Sun, Hong-Wei, Brooks, Stephen R, Hennighausen, Lothar, Kanno, Yuka, O'Shea, John J

“…The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the…”
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PAPST, a User Friendly and Powerful Java Platform for ChIP-Seq Peak Co-Localization Analysis and Beyond by Bible, Paul W, Kanno, Yuka, Wei, Lai, Brooks, Stephen R, O'Shea, John J, Morasso, Maria I, Loganantharaj, Rasiah, Sun, Hong-Wei

“…Comparative co-localization analysis of transcription factors (TFs) and epigenetic marks (EMs) in specific biological contexts is one of the most critical…”
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JAK Inhibition Differentially Affects NK Cell and ILC1 Homeostasis by Vian, Laura, Le, Mimi T, Gazaniga, Nathalia, Kieltyka, Jacqueline, Liu, Christine, Pietropaolo, Giuseppe, Dell'Orso, Stefania, Brooks, Stephen R, Furumoto, Yasuko, Thomas, Craig J, O'Shea, John J, Sciumè, Giuseppe, Gadina, Massimo

“…Janus kinase (JAK) inhibitors are widely used in the treatment of multiple autoimmune and inflammatory diseases. Immunologic and transcriptomic profiling have…”
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