Search Results - "Brooks, Seth"

Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action by Brooks, Seth A., Blackshear, Perry J.

“…Changes in mRNA stability and translation are critical control points in the regulation of gene expression, particularly genes encoding growth factors,…”
Get full text

Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity by Salvat, Regina S., Verma, Deeptak, Parker, Andrew S., Kirsch, Jack R., Brooks, Seth A., Bailey-Kellogg, Chris, Griswold, Karl E.

“…Therapeutic proteins of wide-ranging function hold great promise for treating disease, but immune surveillance of these macromolecules can drive an antidrug…”
Get full text

Deimmunized Lysostaphin Synergizes with Small-Molecule Chemotherapies and Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics by Fang, Yongliang, Kirsch, Jack R, Li, Liang, Brooks, Seth A, Heim, Spencer, Tan, Cynthia, Eszterhas, Susan, Cheng, Hao D, Zhao, Hongliang, Xiong, Yan Q, Griswold, Karl E

“…There is an urgent need for novel agents to treat drug-resistant bacterial infections, such as multidrug-resistant (MRSA). Desirable properties for new…”
Get full text

Experimental Study of Body-Fin Interaction and Vortex Dynamics Generated by a Two Degree-Of-Freedom Fish Model by Brooks, Seth A, Green, Melissa A

“…Oscillatory modes of swimming are used by a majority of aquatic swimmers to generate thrust. This work seeks to understand the phenomenological relationship…”
Get full text

Tristetraprolin regulates TNF TNF-α mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways by Deleault, Kristen M., Skinner, Stephen J., Brooks, Seth A.

“…Tumor necrosis factor-alpha (TNF-α) is a central mediator of inflammation. TNF-α expression is regulated by transcriptional and post-transcriptional…”
Get full text

Cullin 4B is recruited to tristetraprolin-containing messenger ribonucleoproteins and regulates TNF-α mRNA polysome loading by Pfeiffer, Jason R, Brooks, Seth A

“…TNF-α is a central mediator of inflammation and critical for host response to infection and injury. TNF-α biosynthesis is controlled by transcriptional and…”
Get full text

Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity by Lai, Jennifer I., Eszterhas, Susan K., Brooks, Seth A., Guo, Chengzi, Zolla-Pazner, Susan, Seaman, Michael S., Bailey-Kellogg, Chris, Griswold, Karl E., Ackerman, Margaret E.

“…•K155M stabilizes V1V2 β-strand conformation relevant to broad antibody recognition.•β-strand stabilized V1V2 immunogens elicit antibody responses with greater…”
Get full text

Globally deimmunized lysostaphin evades human immune surveillance and enables highly efficacious repeat dosing by Zhao, Hongliang, Brooks, Seth A, Eszterhas, Susan, Heim, Spencer, Li, Liang, Xiong, Yan Q, Fang, Yongliang, Kirsch, Jack R, Verma, Deeptak, Bailey-Kellogg, Chris, Griswold, Karl E

“…There is a critical need for novel therapies to treat methicillin-resistant (MRSA) and other drug-resistant pathogens, and lysins are among the vanguard of…”
Get full text

CARHSP1 Is Required for Effective Tumor Necrosis Factor Alpha mRNA Stabilization and Localizes to Processing Bodies and Exosomes by Pfeiffer, Jason R., McAvoy, Bethany L., Fecteau, Ryan E., Deleault, Kristen M., Brooks, Seth A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Functional interactions between mRNA turnover and surveillance and the ubiquitin proteasome system by Brooks, Seth A.

“…The proteasome is a critical regulator of protein levels within the cell and is essential for maintaining homeostasis. A functional proteasome is required for…”
Get full text

Human Fat-Derived Mesenchymal Stem Cells Xenogenically Implanted in a Rat Model Show Enhanced New Bone Formation in Maxillary Alveolar Tooth Defects by Campbell, Josh, Dhar, M. S., Anderson, David E., Stephenson, Stacy, Masi, Tom, Rodriguez, Rachel, Brooks, Seth, Newby, Steven, Bow, Austin, Wofford, Andrew, Gotcher, Jack

“…Background. Due to restorative concerns, bone regenerative therapies have garnered much attention in the field of human oral/maxillofacial surgery. Current…”
Get full text

Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation by Emmons, Jillian, Townley-Tilson, W H Davin, Deleault, Kristen M, Skinner, Stephen J, Gross, Robert H, Whitfield, Michael L, Brooks, Seth A

“…Dendritic cells provide a critical link between innate and adaptive immunity and are essential to prime a naive T-cell response. The transition from immature…”
Get full text

The Role of mRNA Turnover in the Regulation of Tristetraprolin Expression: Evidence for an Extracellular Signal-Regulated Kinase-Specific, AU-Rich Element-Dependent, Autoregulatory Pathway by Brooks, Seth A, Connolly, John E, Rigby, William F. C

“…Tristetraprolin (TTP) is a regulator of TNF-alpha mRNA stability and is the only trans-acting factor shown to be capable of regulating AU-rich…”
Get full text

Extracellular Signal-regulated Kinase Regulation of Tumor Necrosis Factor-α mRNA Nucleocytoplasmic Transport Requires TAP-NxT1 Binding and the AU-rich Element by Skinner, Stephen J., Deleault, Kristen M., Fecteau, Ryan, Brooks, Seth A.

“…Tumor necrosis factor-α (TNF-α) production is regulated by transcriptional and posttranscriptional mechanisms. Lipopolysaccharide activates the NFκB pathway…”
Get full text

Structure/Function Analysis of Tristetraprolin (TTP): p38 Stress-Activated Protein Kinase and Lipopolysaccharide Stimulation Do Not Alter TTP Function by Rigby, William F. C, Roy, Kristen, Collins, Jane, Rigby, Sam, Connolly, John E, Bloch, Donald B, Brooks, Seth A

“…Tristetraprolin (TTP) is the only trans-acting factor shown to be capable of regulating AU-rich element-dependent mRNA turnover at the level of the intact…”
Get full text

A Flexible Approach to Studying Post-Transcriptional Gene Regulation in Stably Transfected Mammalian Cells by Nichols, Ralph C., Botson, John, Wang, Xiao Wei, Hamilton, B. JoNell, Collins, Jane E., Uribe, Victoria, Brooks, Seth A., Zan, Moe, Rigby, William F. C.

“…The study of post-transcriptional regulation is constrained by the technical limitations associated with both transient and stable transfection of chimeric…”
Get full text

Characterization of the mRNA ligands bound by the RNA binding protein hnRNP A2 utilizing a novel in vivo technique by Brooks, S A, Rigby, W F

“…Post-transcriptional regulation is an important mechanism in cellular response to stimuli, allowing for the rapid and discrete expression of relevant proteins…”
Get full text

What Makes an Idea Risky? The Relations between Perceptions of Idea Novelty, Usefulness, and Risk by Keith, Melissa G., Freier, Lindsey M., Childers, Marie, Ponce‐Pore, Isabelle, Brooks, Seth

“…ABSTRACT Individuals and organizations frequently tout creative ideas as a desirable goal, and yet, creative ideas are frequently rejected. Creativity…”
Get full text

Accurately Detecting Flirting: Error Management Theory, the Traditional Sexual Script, and Flirting Base Rate by Hall, Jeffrey A., Xing, Chong, Brooks, Seth

“…This article reports two studies on the accuracy of flirting detection. In Study 1, 52 pairs (n = 104) of opposite-sex heterosexual strangers interacted for 10…”
Get full text

The ubiquitin E3 ligase Cul4B regulates TTP protein turnover and TNFα mRNA stability independent of p38 (57.6) by Brooks, Seth, Pfeiffer, Jason

“…TNFα is a central mediator of inflammation and is critical for host response to infection and injury. TNFα biosynthesis is controlled by transcriptional and…”
Get full text